Sex hormone-binding globulin, estradiol, and bone turnover markers in male osteoporosis

Lormeau, Claude; Soudan, B.; d’Herbomez, Michèle; Pigny, Pascal; Duquesnoy, B; Cortet, Bernard

doi:10.1016/j.bone.2004.01.024

Cited by 73 publications

(38 citation statements)

References 30 publications

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“…In accordance with most [24][25][26][27] but not all earlier observations [28,29], circulating SHBG was found to negatively correlate with bone parameters. After adjustment for other co-variants, SHBG retained its negative association with bone status only in the younger subgroup.…”

Section: Rycina 1 Zmiany Wskaźnika Masy Ciała (Bmi) (A) Stężenia Wosupporting

confidence: 86%

Wolne i biodostępne frakcje steroidów płciowych mogą wpływać na kości u młodych mężczyzn w zależności od wieku i stężenia estradiolu

Szyska-Skrobot¹,

Marchlewska²,

Walczak-Jędrzejowska³

et al. 2014

Endokrynologia Polska

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Free and bioavailable fractions of sex steroids may influence bones in young men, depending on age and oestradiol level Wolne i biodostępne frakcje steroidów płciowych mogą wpływać na kości u młodych mężczyzn w zależności od wieku i stężenia estradiolu AbstractIntroduction: Longitudinal bone growth ceases by the end of puberty, and it is thought to be a result, in both sexes, of increased pubertal oestrogen serum concentrations. Since peak bone mass is achieved by the third decade of life or later, the aim of this study was to relate sex steroid hormones and sex hormone binding globulin (SHBG) levels to bone quality in men during their third and fourth decades of life. Material and methods: Eighty men, healthy volunteers aged between 18 and 39 years, were subjected to an interviewer-administered questionnaire, body mass index (BMI) measurement, blood sample and calcaneal quantitative ultrasound (QUS) (Hologic-SAHARA). Blood was assessed for testosterone (T), oestradiol (E2), dehydroepiandrosterone sulfate (DHEAS), SHBG, luteinising hormone (LH) and follicle stimulating hormone (FSH). Free and bioavailable T and E2 levels were calculated knowing SHBG and albumin levels. Results: While T, E2, DHEAS, LH and FSH levels were not related, free and bioavailable fractions of T and E2 were positively associated with QUS readings. SHBG level was associated negatively. After dichotomisation for age, the associations remained significant only for younger subjects (18-30 years, n = 47). After adjustment for other co-variants, only SHBG in younger subjects retained its negative association with QUS. Older subjects (31-39 years, n = 33) revealed higher BMI and lower serum concentrations of total (-17 %), free (-18.5%) and bioavailable (-22.5%) levels of E2 than younger subjects. Conclusion: Free and bioavailable fractions of sex steroids may influence bones in young men, depending on age and E2 level.

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Section: Rycina 1 Zmiany Wskaźnika Masy Ciała (Bmi) (A) Stężenia Wosupporting

confidence: 86%

Wolne i biodostępne frakcje steroidów płciowych mogą wpływać na kości u młodych mężczyzn w zależności od wieku i stężenia estradiolu

Szyska-Skrobot¹,

Marchlewska²,

Walczak-Jędrzejowska³

et al. 2014

Endokrynologia Polska

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“…Interleukin-6 signal transducer (gp130) S, C M Heart failure related [99,100], HIV infection [101], tumor related [102], scleroderma [51], chronic renal failure [103], fibromyalgia [104], inflammatory disorders of the skin [105] 3/2 [122], insulin resistance in obese males [123], cardiovascular mortality in elderly men [124] 10/4 34 Thioredoxin S, Sk M Oxidative stress in patients with rheumatoid arthritis [53], skin cancer related [54] 5/0…”

mentioning

confidence: 99%

Suction blister fluid as potential body fluid for biomarker proteins

et al. 2007

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Early diagnosis is important for effective disease management. Measurement of biomarkers present at the local level of the skin could be advantageous in facilitating the diagnostic process. The analysis of the proteome of suction blister fluid, representative for the interstitial fluid of the skin, is therefore a desirable first step in the search for potential biomarkers involved in biological pathways of particular diseases. Here, we describe a global analysis of the suction blister fluid proteome as potential body fluid for biomarker proteins. The suction blister fluid proteome was compared with a serum proteome analyzed using identical protocols. By using stringent criteria allowing less than 1% false positive identifications, we were able to detect, using identical experimental conditions and amount of starting material, 401 proteins in suction blister fluid and 240 proteins in serum. As a major result of our analysis we construct a prejudiced list of 34 proteins, relatively highly and uniquely detected in suction blister fluid as compared to serum, with established and putative characteristics as biomarkers. We conclude that suction blister fluid might potentially serve as a good alternative biomarker body fluid for diseases that involve the skin.

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“…(35) with 105 subjects, 65 of them suffering from idiopathic or secondary osteoporosis (mean age 53.9 years) and 40 age-matched control, SHBG were significantly higher in osteoporotic patients than control, even after secondary osteoporosis (due to alcoholism or hypogonadism) exclusion. Also, SHBG was negatively correlated to femoral neck and lumbar spine BMD, to serum C-telopeptide of type I collagen (CTX), a bone remodeling marker used to evaluate resorption (35). SHBG was significantly associated with fractures; the odds ratio of having a fracture was 2.04 (95%CI: 1.2-3.4; p < 0.01) for each increase of 1 SD in the patient's SHBG level (35).…”

Section: Discussionmentioning

confidence: 98%

“…Also, SHBG was negatively correlated to femoral neck and lumbar spine BMD, to serum C-telopeptide of type I collagen (CTX), a bone remodeling marker used to evaluate resorption (35). SHBG was significantly associated with fractures; the odds ratio of having a fracture was 2.04 (95%CI: 1.2-3.4; p < 0.01) for each increase of 1 SD in the patient's SHBG level (35). SHBG levels are increased in a number of conditions like hyperthyroidism, severe malnutrition, hepatic cirrhosis or aging and may be, more importantly, genetically determined.…”

Section: Discussionmentioning

confidence: 99%

Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men

Clapauch¹,

Mattos²,

Silva³

et al. 2009

Arq Bras Endocrinol Metab

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Objective: To study and establish sex hormone cutoff levels for osteoporosis risk in men over 50 years old. Methods: Case-control study of 216 men > 50 years, 110 with osteoporosis (O) and 106 with normal bone density (C). We measured estradiol (E2), sex hormone binding globulin (SHBG), total testosterone (TT) and albumin. Free testosterone (FT) and bioavailable testosterone (BT) were calculated through Vermeulen's formula. Results: There was no difference in TT between groups. Relative risks of osteoporosis were 1.89 for E2 < 37 pg/mL (p = 0.02); 1.91 for SHBG > 55 nmol/L (p = 0.019); 2.5 for FT < 7 ng/dL (p = 0.015); 2.7 for BT < 180 ng/dL (p = 0.0003). Conclusions:In men over 50 years old, TT was not indicative of osteoporosis risk while E2 < 37 ng/mL was. SHBG > 55 nmol/L, FT < 7 ng/dL and BT < 180 ng/dL can represent additional indications for osteoporosis screening in men over 50 years old. Arq Bras Endocrinol Metab. 2009;53(8):1020-5 Keywords Male osteoporosis; estradiol; testosterone; free estradiol; free testosterone; SHBG resumo Objetivo: Estudar e estabelecer pontos de corte dos hormônios sexuais para risco de osteoporose em homens após os 50 anos de idade. Métodos: Estudo caso-controle de 216 homens > 50 anos, 110 com osteoporose e 106 com densidade óssea normal. Foram dosados: estradiol (E2), globulina ligadora de hormônios sexuais (SHBG), testosterona total (TT) e albumina. Foram calculadas: testosterona livre (TLC) e testosterona biodisponível (TB) pela fórmula de Vermeulen. Resultados: Não houve diferença na TT entre os grupos. Os riscos relativos de osteoporose foram de 1,89 para E2 < 37 pg/mL (p = 0,02); 1,91 para SHBG > 55 nmol/L (p = 0,019); 2,5 para TLC < 7 ng/dL (p = 0,015) e 2,7 para TB < 180 ng/dL (p = 0,0003). Conclusões: Em homens acima de 50 anos, TT não indicou risco de osteoporose, mas E2 < 37 pg/mL sim. SHBG > 55 nmol/L, TLC < 7 ng/dL e TB < 180 ng/dL podem representar indicações adicionais para pesquisa de osteoporose em homens acima de 50 anos. Arq Bras Endocrinol Metab. 2009;53(8):1020-5 Descritores

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Sex hormone-binding globulin, estradiol, and bone turnover markers in male osteoporosis

Cited by 73 publications

References 30 publications

Wolne i biodostępne frakcje steroidów płciowych mogą wpływać na kości u młodych mężczyzn w zależności od wieku i stężenia estradiolu

Wolne i biodostępne frakcje steroidów płciowych mogą wpływać na kości u młodych mężczyzn w zależności od wieku i stężenia estradiolu

Suction blister fluid as potential body fluid for biomarker proteins

Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men

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