Sex hormone-binding globulin and type 2 diabetes mellitus

Abstract

Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic and environmental factors that potentially contribute to the pathophysiology of Type 2 diabetes mellitus (T2DM). In addition to epidemiologic studies demonstrating a consistent relationship between decreased levels of serum SHBG and incident T2DM, recent genetic studies also reveal that transmission of specific polymorphisms in the SHBG gene influence risk of T2DM. On the molecular level, elucidation of the multiple interactions between SHBG and its receptors in various target tissues, suggest physiologic roles for SHBG that are more complex than the simple transport of sex hormones in serum. Taken together, these data provide support for an expanded role of SHBG in the pathophysiology of insulin resistance and T2DM.

Effect of Transdermal Testosterone or Alpha-Lipoic Acid on Erectile Dysfunction and Quality of Life in Patients with Type 2 Diabetes Mellitus / Эффект применения трансдермального тестостерона или альфа-ли- поевой кислоты на эректильную дисфункцию и качество жизни пациентов со сахарным диабетом типа 2

“…In other words, ED has a negative impact on quality of life and the deteriorating quality of life leads to ED. as age increases, is normally expected to be greater than the decrease in total testosterone due to the agerelated increase of SHBG 18 , which is inconsistent with what we found in our patients. Testosterone is directly involved in physiological processes such as self-esteem, sense of well-being, motivation, cognition and memory, muscle mass and strength, while sexual function is an integral part of the satisfaction with life.…”

Dietary patterns and cardiometabolic and endocrine plasma biomarkers in US women

“…Fasting insulin has been associated with the incidence of cardiovascular disease (39,40), and elevated C-peptide has been associated with the incidence of coronary artery disease and with cardiovascular and total mortality in individuals without diabetes (41,42). In addition, lower SHBG was consistently associated with the incidence of T2D in epidemiologic studies (43).…”

PCOS and diabetes mellitus: from insulin resistance to altered beta pancreatic function, a link in evolution

“…Several researches have proved a negative correlation between SHBG levels and insulin sensitivity [5]. In addition, most prospective studies support the role of reduced SHBG levels as a possible predictive factor of DM2 development [6]. How SHBG reduction may influence insulin sensitivity is still unknown.…”

“…How SHBG reduction may influence insulin sensitivity is still unknown. It is possible to assume that IR is a consequence of abnormal sexual hormones transport and thus, this causes a reduced glucose uptake in muscular tissue [6].…”