Sex differences in stress responses: Focus on ovarian hormones

Horst, Gert J. Ter; Wichmann, Romy; Gerrits, Marjolein; Westenbroek, Christel; Lin, Yuan

doi:10.1016/j.physbeh.2009.02.036

Cited by 138 publications

(103 citation statements)

References 105 publications

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“…Other studies have increased the exposure period to similar stressors for longer periods of time (i.e., more than 3 weeks). 30 In addition, it is also worth pointing that there is evidence for sex differences with regards to stress responses, 31 and since the present study only included male rats, we cannot exclude the possibility that a different response to the stress protocols used in this study could be observed in females.…”

mentioning

confidence: 88%

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives

et al. 2017

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mentioning

confidence: 88%

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives

et al. 2017

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“…Steroid hormones, in particular progesterone and estrogen, have effects on the gastric motility and secretions [19], and are also involved in the pathogenesis of some functional disorders in the gut [20]. This might provide a sensible explanation for the clinically observed gender difference in the prevalence of duodenal ulcer (Table 1 [ [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62]). …”

Section: Tbi Gi Tract and Sex Hormonesmentioning

confidence: 99%

“…The role of gonadal hormones, in symptomatology and pathophysiology of IBS is being recognized based on the female predominance as well as the relation between IBS symptoms and hormonal status during menstrual cycle phases, pregnancy or menopause [75]. IBS is a GI sensory-motor disorder characterized by abdominal pain or discomfort linked with changes in bowel habits [59]. Li et al noted that the expression of 5-HT3 receptor mRNA was considerably decreased in rats after E2 + P treatment as compared to sham-treated ovariectomized rats that often coexist with IBS [76].…”

Section: Tbi Gi Tract and Sex Hormonesmentioning

confidence: 99%

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Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

et al. 2017

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Traumatic brain injury (TBI) is an important public health problem which can lead to several complications like gastrointestinal dysfunction. Patients with TBI often suffer from gastrointestinal dysfunctions such as enteral feeding intolerance. Gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. TBI causes a delayed but significant decrease in intestinal contractile activity in the ileum leading to delayed transport. The association between severity of brain injury and enteral feeding intolerance suggests a strong link between the central nervous system and the non-functional gut. The results of recent basic and clinical studies revealed the beneficial effects of estrogen and progesterone hormones in the treatment of gastrointestinal dysfunction. Females have more resistance to stress and fewer gastrointestinal lesions occur in females as compared to males. Sex steroid hormones have sparked interest as possible neuroprotective agents after traumatic injury and many studies have been done on this subject. This article reviews the literature related to some possible physiological effects of female sexual hormones on the gastrointestinal tract following TBI.

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“…Recently, sex has been increasingly recognized as one of the major variables to affect the sensitivity to stress [19][20][21]. For example, in response to stress, changes in feeding behavior, taste preference, and body weight are different between males and females [22,23].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Antinociceptive Effects Induced by Gravity Stress in Rats

Kimoto¹,

Zeredo²,

Nihei³

et al. 2013

JBBS

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A number of studies have demonstrated that sex differentially affects responses to stress and pain. In this study, sex-related differences in pain responding were investigated in a gravity-induced analgesia model, where the effects of stressful high-gravity loading (1.5G or 2.0G for 10 min) on nociceptive behavior in male and female rats were investigated. In each rat, eight sites (nose, both forepaws, upper and lower back, both hind paws and tail) were selected to apply noxious stimuli using a von Frey-type needle stimulator. The threshold values of the withdrawal responses were measured. In order to confirm the involvement of endogenous opioids in gravity-induced antinociceptive effects, naloxone-HCl (an opioid antagonist) was used. Effective analgesic effects could be induced by strong (2.0G) gravity loading, and clear sex differences were observed. Gravity-induced analgesic effects were more effective in males than in females, indicating that males are more sensitive to stress than females judging from nociceptive modulation. Naloxone-HCl produced a more pronounced suppression of nociceptive behavior in male rats, suggesting that gravity loading may activate endogenous opioids more readily in males than in females.

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Sex differences in stress responses: Focus on ovarian hormones

Cited by 138 publications

References 105 publications

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives

Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

Sex Differences in Antinociceptive Effects Induced by Gravity Stress in Rats

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