Sex Differences in Cardiometabolic Health Indicators after HIIT in Patients with Coronary Artery Disease

Way, Kimberley L.; Vidal-Almela, Sol; Moholdt, Trine; Currie, Katharine D.; Aksetøy, Inger-Lise Aamot; Boidin, Maxime; Cornelissen, Véronique; Joa, Kyung-Lim; Keech, Andrew; Jayo-Montoya, Jon Ander; Taylor, Jenna L.; Fouriner, Karine; Reed, Jennifer L.

doi:10.1249/mss.0000000000002596

Cited by 10 publications

(18 citation statements)

References 52 publications

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“…Our meta-analysis in patients with coronary artery disease revealed smaller absolute improvements in VȮ 2 peak, BMI and fasting plasma glucose in females than males following HIIT (Way et al 2021). Given the analysis revealed an 8-fold greater participation of males than females, additional data in females is needed (Way et al 2021). In contrast, in an analysis of randomized trials (only 8 females and 19 males engaged in HIIT), VȮ 2 peak in mL/kg/min improved similarly in both sexes (Trachsel et al 2020).…”

Section: Introductionmentioning

confidence: 64%

“…There is a paucity of sex-based evaluations of HIIT (Lee et al 2018;Terada et al 2019a;Rengo et al 2020;Trachsel et al 2020;Way et al 2021). Our primary finding aligns with an analysis of randomized trials including MICT and HIIT which did not find time by sex interactions in VȮ 2 peak with (∆ females: 1.9±2.5; males: 2.9±3.5 mL/kg/min, p=0.255) or without (∆ females: 1.1±2.1; males: 2.0±2.6 mL/kg/min, p=0.116) lean body mass adjustment (Trachsel et al 2020).…”

Section: ))mentioning

confidence: 99%

“…HIIT evaluations presenting outcomes by sex are scarce, with small sample sizes (particularly of females), inconsistent findings (Sandercock et al 2013;Witvrouwen et al 2019;Rengo et al 2020;Trachsel et al 2020;Way et al 2021), and often fail to measure mental health outcomes (Lee et al 2018;Terada et al 2019a;Rengo et al 2020;Way et al 2021). Our meta-analysis in patients with coronary artery disease revealed smaller absolute improvements in VȮ 2 peak, BMI and fasting plasma glucose in females than males following HIIT (Way et al 2021). Given the analysis revealed an 8-fold greater participation of males than females, additional data in females is needed (Way et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…This research gap merits examination as females with CVD often report greater anxiety and depression than males (Todaro et al 2007;Shanmugasegaram et al 2012), which increase cardiovascular event recurrence and mortality risk (van Melle et al 2004). Further, the underreporting of exercise adherence by sex precludes knowing whether differences in adherence explain sex differences in physical and mental health following CR (Way et al 2021).…”

Section: Introductionmentioning

confidence: 99%

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Sex differences in physical and mental health following high-intensity interval training in adults with cardiovascular disease who completed cardiac rehabilitation

Vidal-Almela

Way

Terada

et al. 2022

Appl. Physiol. Nutr. Metab.

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This pre-post study examined sex-differences in peak aerobic power (V̇O2peak) and physical- and mental-health outcomes in adults with cardiovascular disease who completed high-intensity interval training (HIIT)-based cardiac rehabilitation. HIIT consisted of 25 minutes of alternating higher- (4 minutes 85-95% HRpeak) and lower- (3 minutes 60-70% HRpeak) intensity intervals twice weekly for 10 weeks. V̇O2peak estimated from a graded exercise test using the ACSM equation, body mass index (BMI), waist circumference, blood pressure, blood biomarkers and anxiety and depression were assessed at baseline and follow-up. Linear mixed-effects models for repeated measures were performed to examine differences over time between sexes. Of 140 participants (mean ± standard deviation: 58±9 years), 40 were female. Improvements in V̇O2peak did not differ between sexes (interaction: p=0.273, females: 28.4±6.4 to 30.9±7.6; males: 34.3±6.3 to 37.4±6.0 mL/kg/min). None of the time by sex interactions were significant. Significant main effects of time showed reductions in waist circumference, triglycerides, LDL, TC/HDL and anxiety, and increases in V̇O2peak and HDL from baseline to follow-up. Significant main effects of sex revealed smaller V̇O2peak, BMI and waist circumference, and higher LDL, TC and HDL in females than males. HIIT led to similar improvements in estimated V̇O2peak (females: 8.8%, males: 9.0%) and additional health outcomes between sexes. Novelty • HIIT-based CR led to similar improvements in estimated V̇O2peak and other physical and mental health outcomes between sexes. • The number of sessions attended was high (>70%) and did not differ by sex. • Both sexes showed good compliance with the exercise protocol (HR target).

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Section: Introductionmentioning

confidence: 64%

Section: ))mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sex differences in physical and mental health following high-intensity interval training in adults with cardiovascular disease who completed cardiac rehabilitation

Vidal-Almela

Way

Terada

et al. 2022

Appl. Physiol. Nutr. Metab.

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“…Pattyn et al found HIIT protocols that were isocaloric with MICT were more likely to show superiority over MICT (+2.1 mL/kg/min) compared with HIIT protocols that were a lower energy expenditure to MICT (+0.2 mL/kg/min) (52). Furthermore, Way et al (83) demonstrated that although women tend to experience lower absolute improvements in VO 2 peak with HIIT than men, they have similar relative improvements in VO 2 peak (83) . The FITR Heart Study, a recently published pragmatic trial in 93 CAD patients using RPE as the primary method of exercise prescription (36), also demonstrated a superior effect of HIIT compared with MICT during a 4-week CR program, with a mean difference in VO 2 peak improvement of 1.7 mL/kg/min.…”

Section: Influence Of Exercise Intensity On Cvd and Mortalitymentioning

confidence: 99%

Optimizing Outcomes in Cardiac Rehabilitation: The Importance of Exercise Intensity

Taylor

Bonikowske

Olson

2021

Front. Cardiovasc. Med.

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Exercise based cardiac rehabilitation (CR) is recognized internationally as a class 1 clinical practice recommendation for patients with select cardiovascular diseases and heart failure with reduced ejection fraction. Over the past decade, several meta-analyses have generated debate regarding the effectiveness of exercise-based CR for reducing all-cause and cardiovascular mortality. A common theme highlighted in these meta-analyses is the heterogeneity and/or lack of detail regarding exercise prescription methodology within CR programs. Currently there is no international consensus on exercise prescription for CR, and exercise intensity recommendations vary considerably between countries from light-moderate intensity to moderate intensity to moderate-vigorous intensity. As cardiorespiratory fitness [peak oxygen uptake (VO2peak)] is a strong predictor of mortality in patients with coronary heart disease and heart failure, exercise prescription that optimizes improvement in cardiorespiratory fitness and exercise capacity is a critical consideration for the efficacy of CR programming. This review will examine the evidence for prescribing higher-intensity aerobic exercise in CR, including the role of high-intensity interval training. This discussion will highlight the beneficial physiological adaptations to pulmonary, cardiac, vascular, and skeletal muscle systems associated with moderate-vigorous exercise training in patients with coronary heart disease and heart failure. Moreover, this review will propose how varying interval exercise protocols (such as short-duration or long-duration interval training) and exercise progression models may influence central and peripheral physiological adaptations. Importantly, a key focus of this review is to provide clinically-relevant recommendations and strategies to optimize prescription of exercise intensity while maximizing safety in patients attending CR programs.

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Acute physiological responses to high-intensity interval exercise in patients with coronary artery disease

Currie

Dizonno

et al. 2022

Eur J Appl Physiol

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Sex Differences in Cardiometabolic Health Indicators after HIIT in Patients with Coronary Artery Disease

Abstract: Supplemental digital content is available in the text.

Cited by 10 publications

References 52 publications

Sex differences in physical and mental health following high-intensity interval training in adults with cardiovascular disease who completed cardiac rehabilitation

Sex differences in physical and mental health following high-intensity interval training in adults with cardiovascular disease who completed cardiac rehabilitation

Optimizing Outcomes in Cardiac Rehabilitation: The Importance of Exercise Intensity

Acute physiological responses to high-intensity interval exercise in patients with coronary artery disease

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