Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia

Yang, Fang; Wang, Ke‐Ming; Du, Xiangdong; Deng, Huiqiong; Wu, Hanjing Emily; Yin, Guiqin; Ning, Yuping; Huang, Xingbing; Teixeira, Antônio Lúcio; Quevedo, Joao L De; Soares, Jair C.; Li, Xiaosi; Lang, Xiaoe; Zhang, Xiang Yang

doi:10.1007/s00213-018-5107-1

Cited by 30 publications

(15 citation statements)

References 64 publications

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“…However, we did not collect these data in this study, which should be remedied in future studies. Fourth, previous studies found that there was sex difference in obesity in patients with schizophrenia 59 . However, in this study, we included much fewer female patients than male patients, which may have affected the results due to an imbalance in the sex ratio.…”

Section: Discussionmentioning

confidence: 94%

Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia

Huang

et al. 2020

Sci Rep

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Obesity is common comorbidity in patients with schizophrenia. Previous studies have reported that homocysteine (Hcy) is increased in schizophrenia. However, no study has reported the association between BMI and Hcy levels in schizophrenia. This cross-sectional naturalistic study aimed to evaluate the relationship between BMI, Hcy and clinical symptoms in Chinese Han patients with chronic schizophrenia. Clinical and anthropometric data as well as plasma Hcy level and glycolipid parameters were collected. Psychopathology was measured with the Positive and Negative Syndrome Scale (PANSS). Our results showed that compared with the low BMI group, the high BMI group had a higher PANSS general psychopathology subscore, higher levels of blood glucose, total cholesterol and high-density lipoprotein (HDL) cholesterol (all p < 0.05). Hcy levels were negatively associated with BMI in patients (p < 0.001). Hcy level, the PANSS general psychopathology subscale, total cholesterol and education (all p < 0.05) were the influencing factors of high BMI. Our study suggest that Hcy level may be associated with BMI in patients with schizophrenia. Moreover, patients with high BMI show more severe clinical symptoms and higher glucose and lipid levels.

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Section: Discussionmentioning

confidence: 94%

Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia

Huang

et al. 2020

Sci Rep

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“…showed that there are obvious sex differences in the relationship between BDNF and BMI (20). This also reminds us to consider sex factors when discussing the relationship between BDNF and metabolism.…”

Section: Discussionmentioning

confidence: 71%

“…Brain-derived neurotrophic factor (BDNF) is a kind of energy balance regulator that also plays an important role in the central regulation of food intake and body weight ( 20 , 21 ). Moreover, BDNF is an important member of the neurotropic factor family, which is widely distributed in the central nervous system ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, animal experiments have shown that blood BDNF levels are positively correlated with brain BDNF levels ( 31 ). Interestingly, many studies have found significant sex differences in BDNF levels in patients with schizophrenia ( 20 , 32 ). Moreover, there were significant sex differences in the correlation between BDNF and cognition in patients with schizophrenia ( 33 ).…”

Section: Introductionmentioning

confidence: 99%

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Sex Differences in the Association of HOMA-IR Index and BDNF in Han Chinese Patients With Chronic Schizophrenia

et al. 2021

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Background: Previous research has indicated that there are significant sex differences in serum BDNF levels and metabolic indicators in patients with schizophrenia. Studies have found that BDNF is involved in blood sugar regulation. Homeostasis model assessment of insulin resistance (HOMA-IR) is currently a sensitive indicator for measuring insulin resistance. Our study aims to explore the sex differences in the relationship between serum BDNF levels and HOMA-IR in patients with chronic schizophrenia (CS).Methods: A total of 332 patients with CS were enrolled in this study. General information of all participants was collected. Haematological indicators were collected, and the Positive and Negative Syndrome Scale (PANSS) was used to evaluate psychiatric symptoms. Sex differences in serum BDNF levels, HOMA-IR index and other metabolic indexes were investigated. Then, linear regression analysis was used to analyse the relationship between the HOMA-IR index and BDNF levels in male and female patients.Results: The HOMA-IR index of female patients was significantly higher than that of males, but there was no significant difference in serum BDNF levels between male patients and female patients. There was a positive correlation between BDNF level and HOMA-IR index, and this relationship only existed in female patients.Conclusion: The results show that there are significant sex differences in HOMA-IR in patients with CS. In addition, only in female patients was there a positive correlation between the HOMA-IR index and BDNF level, which suggests that sex factors should be taken into account in evaluating the relationship between BDNF and blood glucose in patients with CS.

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“…The contradictory results in the literature may be due to the effect of gender on BDNF responses. It has been reported that gender has an effect on the relationship between the BDNF level and general cognitive functions in schizophrenia, and this relationship is only observed in women (88). In this review, homogeneous groups were not included in the studies examined, and the effect of BDNF and cognitive functions were observed in mixed groups.…”

Section: Reviewing the Findings On Mdd And Schizophrenia Togethermentioning

confidence: 99%

Effect of Exercise on Cognition in Neurodegenerative Disorders: An Approach Focusing on BDNF

Gökçe¹,

Güneş²,

Nalçacı³

2019

Archives of Neuropsychiatry

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Psychiatric disorders are remarkable health problems that cause a massive social and economic burden, and the issue of their long-term and effective treatment is subjected to discussion. The effect of physical activity and exercise is under investigation in the treatment of the major depressive disorder (MDD) and schizophrenia which are accompanied by cognitive dysfunctions. Scientists focus on the positive effects of exercise on learning, memory and attention parameters while investigating the regulatory role of brain-derived neurotrophic factor (BDNF). In this review, the effect of aerobic exercise on peripheral BDNF levels in MDD and schizophrenia is examined by including human studies in which acute and chronic aerobic exercise are applied. The results showed that aerobic exercise caused different responses on BDNF levels, and some of the studies were accompanied by the improvement in cognitive functions in BDNF changes. In order to comprehend the effect of aerobic exercise in MDD and schizophrenia, it is understood that applying studies on larger and paired participant groups with different exercise frequencies and tensions in necessary.

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Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia

Cited by 30 publications

References 64 publications

Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia

Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia

Sex Differences in the Association of HOMA-IR Index and BDNF in Han Chinese Patients With Chronic Schizophrenia

Effect of Exercise on Cognition in Neurodegenerative Disorders: An Approach Focusing on BDNF

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