Sex-Dependent Effects of High-Fat-Diet Feeding on Rat Pancreas Oxidative Stress

Gómez-Pérez, Yolanda; Gianotti, Magdalena; Lladó, Isabel; Proenza, Ana M.

doi:10.1097/mpa.0b013e31821f2645

Cited by 17 publications

(9 citation statements)

References 38 publications

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“…This is consistent with the findings in both rodents and humans, demonstrating a gender difference in oxidative stress, with females characterized by lower levels of oxidative stress than males [22]. Reactive oxygen species (ROS) production was lower and activity of antioxidant enzymes was higher in females compared to males [23,24]. Accordingly, NAC administration during pregnancy and lactation increased the resistance of male islets to oxidative stress, while females were not affected, suggesting that NAC is involved in the programming of the antioxidant defense mechanisms, which enables better accommodation with oxidative stress.…”

Section: Discussionsupporting

confidence: 90%

Maternal N-Acetyl Cysteine Intake Improved Glucose Tolerance in Obese Mice Offspring

Michlin

Argaev-Frenkel

Weinstein-Fudim³

et al. 2020

IJMS

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Exposure to certain environmental factors during the early stages of development was found to affect health in adulthood. Among other environmental factors, oxidative stress has been suggested to be involved in fetal programming, leading to elevated risk for metabolic disorders, including type 2 diabetes; however, the possibility that antioxidant consumption during early life may affect the development of diabetes has scarcely been studied. The aim of this study was to investigate the effects of N-acetyl-l-cysteine (NAC) given during pregnancy and lactation on the susceptibility of offspring to develop glucose intolerance at adulthood. C57bl6/J mice were given NAC during pregnancy and lactation. High fat diet (HFD) was given to offspring at an age of 6 weeks for an additional 9 weeks, till the end of the study. Isolated islets of NAC-treated offspring (6 weeks old, before HFD feeding) had an increased efficacy of glucose-stimulated insulin secretion and a higher resistance to oxidative damage. Following HFD feeding, glucose tolerance and insulin sensitivity of NAC-treated offspring were improved. In addition, islet diameter was lower in male offspring of NAC-treated mice compared to their HFD-fed littermates. NAC consumption during early life improves glucose tolerance in adulthood in mice.

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Section: Discussionsupporting

confidence: 90%

Maternal N-Acetyl Cysteine Intake Improved Glucose Tolerance in Obese Mice Offspring

Michlin

Argaev-Frenkel

Weinstein-Fudim³

et al. 2020

IJMS

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“…Catalase activity levels were found to be the same between genders in the brain, heart, lung and heart, but higher in the female kidney . However, some studies showed no difference in catalase activity levels between males and females . These data suggest that catalase activity and thus hydrogen peroxide degradation may not be affected by gender and sex hormones.…”

Section: Gender and Oxidative Stressmentioning

confidence: 84%

“…This suggests that there is a gender‐specific difference in the pathophysiology of AITP. In regard to pancreatic disease, female rats exhibit higher protection against oxidative stress and thus have a lower risk of developing insulin resistance compared to male rats . In addition to these disease states, oxidative stress and gender have been shown to be associated with ageing.…”

Section: Gender Oxidative Stress and Diseasesmentioning

confidence: 99%

Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases

Kander

Cui

Liu

2016

J Cellular Molecular Medi

366

238

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Gender differences are present in many diseases and are especially prevalent in cardiovascular disease. Males tend to suffer from myocardial infarctions earlier than females, and a woman's risk of cardiovascular disease increases after menopause, suggesting a cardio‐protective role of estrogen. However, hormone replacement therapy did not decrease the risk of cardiovascular disease in post‐menopausal women; thus, other mechanisms may be involved besides estrogen. Oxidative stress plays an important role in the development of cardiovascular diseases such as coronary artery disease. Gender is also associated with differences in oxidative stress. Under physiological conditions, females appear to be less susceptible to oxidative stress. This may be due to the antioxidant properties of estrogen, gender differences in NADPH‐oxidase activity or other mechanism(s) yet to be defined. This review strives to discuss gender differences in general terms followed by a more detailed examination of gender differences with oxidative stress and various associated diseases and the possible mechanisms underlying these differences.

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“…However, some studies did not demonstrate differences in the level of catalase activity between men and women [56,57,62]. Thus, the studies cited above indicate that gender and sex hormones do not affect catalase activity, and thus, the degradation of hydrogen peroxide [63].…”

Section: Discussionmentioning

confidence: 96%

Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Associated with Overweight and Obesity

Nowicki¹,

Ślusarska²,

Prystupa³

et al. 2019

Preprint

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Obesity is one of the factors leading to the development of atherosclerosis. This metabolic disorder is associated with an increased production of reactive oxygen species, which affect the oxidative stress level. The aim of this study was to evaluate oxidative/antioxidative status and to investigate the correlation between redox markers and anthropometric parameters and body composition in adult patients after myocardial infarction and in individuals without a cardiovascular event in the past. Descriptive data on socio-demographic, clinical, and anthropometric features and blood samples were collected and categorized into two equal groups: after myocardial infarction (study group (SG), n = 80) and without a cardiovascular event (control group (CG), n = 80). The oxidative/antioxidative status was assessed in plasma on the basis of total oxidative/capacitive status (PerOx), total antioxidative status/capacity (ImAnOx), and oxidized low-density lipoprotein (oxLDL). OxLDL was significantly higher in the CG group compared to the SG group (p = 0.02). No significant differences were found with regard to PerOx and ImAnOx values between the studied groups. Significant positive correlation between PerOx and percentage of adipose tissue (FM [%]) and body adiposity index (BAI) was found in the two studied groups. ImAnOx significantly positively correlated with VAI in SG and FM% in CG. OxLDL negatively correlated with body mass index and waist to hip circumference ratio in CG. The total oxidative/antioxidative status is related to the amount of adipose tissue and the BAI of the subjects. It was observed that it correlates more frequently with the visceral distribution of body fat.

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Sex-Dependent Effects of High-Fat-Diet Feeding on Rat Pancreas Oxidative Stress

Cited by 17 publications

References 38 publications

Maternal N-Acetyl Cysteine Intake Improved Glucose Tolerance in Obese Mice Offspring

Maternal N-Acetyl Cysteine Intake Improved Glucose Tolerance in Obese Mice Offspring

Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases

Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Associated with Overweight and Obesity

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