Sex-dependent and -independent regulation of thyrotropin-releasing hormone expression in the hypothalamic dorsomedial nucleus by negative energy balance, exercise, and chronic stress

Vargas, Yamili; de, Marco Parra-Montes; Sánchez-Jaramillo, Edith; Jaimes-Hoy, Lorraine; Sánchez-Islas, Eduardo; Uribe, R.M.; Joseph‐Bravo, Patricia; Charlí, Jean-Louis

doi:10.1016/j.brainres.2022.148083

Cited by 3 publications

(9 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TRH perifornical neurons also project to the VMH [155], which contains a very high density of UCN3/TRH axons, especially in its dorsomedial part [166]. TRH decreases food intake when injected into the medio-basal hypothalamus [164], a region including the VMH, but the precision of the injection is insufficient to be categorical about the target region, and the density of TRH receptors is very low in the VMH [81,158] The TMN contains TRH axons that originate, at least in part, in the tuberal LH (TuLH). The TRH TuLH neuron terminals impinge on histaminergic neurons in all subdivisions of the TMN, where approximately half of the histaminergic neurons co-express Trhr [167,168].…”

Section: Trh Rostral Perifornical Lh Neuronsmentioning

confidence: 99%

“…The ARC has a TRH innervation [ 156 ] arising, at least in part, from the aPVH [ 155 ] and expresses both Trhr and Trhr2 [ 81 , 157 , 158 ]. In mice, an orexigenic (through glutamate) glutamatergic PVH->ARC projection expresses Trh [ 159 ], but the precise location of the PVH neurons projecting onto the AgRP neurons and the specific role of TRH in this projection remain unknown.…”

Section: In Search Of the Central Circuits Involved In Trh Action On ...mentioning

confidence: 99%

See 1 more Smart Citation

Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

Vargas,

Castro Tron,

Rodríguez Rodríguez

et al. 2024

Metabolites

Self Cite

View full text Add to dashboard Cite

Thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food intake is not well understood. We review studies demonstrating that peripheral injection of TRH generally produces a transient anorexic effect, discuss the pathways that might initiate this effect, and explain its short half-life. In addition, central administration of TRH can produce anorexic or orexigenic effects, depending on the site of injection, that are likely due to interaction with TRH receptor 1. Anorexic effects are most notable when TRH is injected into the hypothalamus and the nucleus accumbens, while the orexigenic effect has only been detected by injection into the brain stem. Functional evidence points to TRH neurons that are prime candidate vectors for TRH action on food intake. These include the caudal raphe nuclei projecting to the dorsal motor nucleus of the vagus, and possibly TRH neurons from the tuberal lateral hypothalamus projecting to the tuberomammillary nuclei. For other TRH neurons, the anatomical or physiological context and impact of TRH in each synaptic domain are still poorly understood. The manipulation of TRH expression in well-defined neuron types will facilitate the discovery of its role in food intake control in each anatomical scene.

show abstract

Section: Trh Rostral Perifornical Lh Neuronsmentioning

confidence: 99%

Section: In Search Of the Central Circuits Involved In Trh Action On ...mentioning

confidence: 99%

Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

Vargas,

Castro Tron,

Rodríguez Rodríguez

et al. 2024

Metabolites

Self Cite

View full text Add to dashboard Cite

show abstract

“…TRH terminals are detected in the DMH [163], where a significant population of cells expresses Trhr [158]. In rats accustomed to a daily 4 h food-intake and drinking schedule, the bilateral injection of 8 nmoles of TRH per hemisphere in the medio basal hypothalamus (centered around the DMH, although the precision of the procedure is insufficient to be categorical about DMH relevance) produces a sustained (maximum at 30 min, still significant at 3 h reduction of food-intake in 20 h food and water deprived male adult rats [164].…”

Section: Trh Anterior Pvh Neuronsmentioning

confidence: 99%

“…TRH perifornical neurons also project to the VMH [155], which contains a very high density of UCN3/TRH axons, especially in its dorsomedial part [166]. TRH decreases food-intake when injected into the medio-basal hypothalamus [164], a region including the VMH, but the precision of the injection is insufficient to be categorical about the target region, and the density of TRH receptors is very low in the VMH [81,158] The TMN contains TRH axons that originate, at least in part, in the tuberal LH (TuLH). The TRH TuLH neuron terminals impinge on histaminergic neurons in all subdivisions of the TMN, where approximately half of the histaminergic neurons co-express Trhr [168].…”

Section: Trh Rostral Perifornical Lh Neuron Projectionsmentioning

confidence: 99%

“…Some of the DMH neurons that project to the LH express Trh mRNA [42]. TRH terminals [161,163] and Trhr expression [81,158] are abundant in the LH. In rats accustomed to a daily 4 h food-intake and drinking schedule, the intracranial bilateral injection of 8 nmoles of TRH per hemisphere in the LH does not change foodintake in 20 h food and water deprived male adult rats [164].…”

Section: Trh Dmh Neurons Projection Onto Lh Gaba Neurons That Control...mentioning

confidence: 99%

See 1 more Smart Citation

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Vargas,

Castro Tron,

Charli

et al. 2024

Preprint

View full text Add to dashboard Cite

Thyrotropin releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food-intake is not well understood. We review data that show that peripheral injection of TRH generally produces a transient anorexic effect, discuss the pathways that might initiate this effect, and explain its short half-life. In addition, central administration of TRH can produce anorexic or orexigenic effects, depending on the site of injection, that are likely due to interaction with TRH receptor 1. Anorexic effects are most notable when TRH is injected into the hypothalamus and the nucleus accumbens, while the orexigenic effect has only been detected by injection into the brain stem. Functional evidence suggests that TRH neurons that are prime candidate vectors for TRH action on food-intake include the caudal raphe nuclei projecting to the dorsal motor nucleus of the vagus, and possibly TRH neurons from the tuberal lateral hypothalamus projecting to the tuberomammillary nuclei. For other TRH neurons, the anatomical or physiological context and impact of TRH in each synaptic domain are still poorly understood. The manipulation of TRH expression in well-defined neuron types will facilitate the discovery of its role in food-intake control in each anatomical scene.

show abstract