Sex and age differences in mortality trends of gastric cancer among Hispanic/Latino populations in the United States, Latin America, and the Caribbean

Torres-Román, J. Smith; Álvarez, Christian S.; Guerra-Canchari, Pedro; Valcárcel, Beatriz González López; Martínez-Herrera, José Fabián; Dávila-Hernández, Carlos A.; Santos, Camila Alves dos; Soares, Samara Carollyne Mafra; Souza, Dyego Leandro Bezerra de; Camargo, M. Constanza

doi:10.1016/j.lana.2022.100376

Cited by 4 publications

(6 citation statements)

References 31 publications

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“…Stomach cancer remains the first leading cause of cancer death among men in Chile and Colombia ( Collatuzzo et al ., 2023 ). Analyses for different age groups showed a less pronounced decrease in mortality trends in the young, particularly women, for most countries considered reflecting a levelling of low rates and possible unfavourable trends among young adults ( Camargo et al ., 2011 ; Anderson et al ., 2018 ; Arnold et al ., 2020 ; Heer et al ., 2020 ; Santucci et al ., 2021 ; Torres-Roman et al ., 2022 ). Genetic factors also have a possible relevant impact on the young ( Corso et al ., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Cancer mortality predictions for 2023 in Latin America with focus on stomach cancer

Santucci

Malvezzi

Levi

et al. 2023

European Journal of Cancer Prevention

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Objective We estimated cancer mortality statistics for the current year in seven major Latin American countries. MethodsWe retrieved official death certification data and population figures from the WHO and the United Nations databases for the 1970-2020 calendar period. We considered mortality from all neoplasms combined and for 10 major cancer sites. We estimated the number of deaths and age-standardized mortality rates for the year 2023. ResultsAge-standardized mortality rates for all cancers combined are predicted to decline in all countries, in both sexes, apart from Venezuelan women. The lowest predicted total cancer mortality rates are in Mexico, 69.8/100 000 men and 62.5/100 000 women. The highest rates are in Cuba with 133.4/100 000 men and 90.2/100 000 women. Stomach cancer is predicted to decline steadily in all countries considered, but remains the first-ranking site for men in Chile (14.3/100 000) and Colombia (11/100 000). Colorectal cancer rates also tended to decline but remain comparatively high in Argentina (14/100 000 men). Breast cancer rates were high in Argentinian women (16.5/100 000) though they tended to decline in all countries. Lung cancer mortality rates are also predicted to decline, however, rates remain exceedingly high in Cuba (30.5/100 000 men and 17.2/100 000 women) as opposed to Mexico (5.6/100 000 men and 3.2/10 000 women). Declines are also projected for cancer of the uterus, but rates remain high, particularly in Argentina and Cuba (10/100 000 women), and Venezuela (13/100 000 women) due to inadequate screening and cervical cancer control.

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Section: Discussionmentioning

confidence: 99%

Cancer mortality predictions for 2023 in Latin America with focus on stomach cancer

Santucci

Malvezzi

Levi

et al. 2023

European Journal of Cancer Prevention

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“…This study describes the incidence and mortality of Latin patients diagnosed with GC.This type of cancer is the second most common neoplasm within gastrointestinal pathologies in our hospital and one of the leading cancer diagnoses and mortality in our country and the Latin Hispanic population ( 21 , 22 ). Even though the incidence and mortality of GC is mostly in patients aged 50 years or more, in the past 30 years, the diagnosis of GC has increased in younger adults ( 5 , 23 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

Latin American young patients with gastric adenocarcinoma: worst prognosis and outcomes

Calderillo-Ruíz,

Díaz-Romero,

Carbajal-López

et al. 2023

J Gastrointest Oncol

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Background Incidence of young patients (aged 40 years or younger) diagnosed with gastric carcinoma has increased worldwide. Young GC diagnosis, have clinicopathological features that differ from elderly, and is correlated with bad prognosis factors. The purpose of this work is to describe the prevalence, clinic-pathological features, and prognosis of overall survival (OS) of young Latin-American patients with GC. Methods Retrospective, observational study. Included patients treated at the National Cancer Institute [2004–2020]. Statistical analysis: χ 2 and t -test, Kaplan-Meier, Log-Rank and Cox-Regression. Statistical significance differences were assessed when P was bilaterally <0.05. Results A total of 2,543 patients fulfilled the inclusion criteria. Young-patients were predominantly female (54%), with diffuse-type adenocarcinoma (68%), signet-ring-cell (72%), poor-differentiation (90%), and metastatic (79%). In OS analysis, patients with metastatic disease, showed differences regarding age, young patients reported a median-OS of 8 versus 13 months for elderly patients (P=0.001). Among young patients, differences were also observed regarding gender, young-female patients had a median-OS of 5 versus 11 months for young-man (P=0.001). Conclusions This is one of the pioneer studies correlating age with gender and the prognostic features of bad prognosis in Latin-American population. Besides, supports the idea that a global effort is required to improve awareness, prevention, and early diagnosis of GC.

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“…Most patients with GC are diagnosed at late stages, and ∼97,000 individuals die from this cancer each year in the region (Globocan 2020). The disease burden is greatest in low- and middle-income countries, 1 and specific marginalized groups in high-income countries. 2 Due to aging and growing of high-risk populations, the absolute burden of GC is estimated to rise in the Americas.…”

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confidence: 99%

“…2 In Latin America and the Caribbean, individuals with lower socioeconomic status have increased GC incidence and mortality. 1 Across the Americas, Indigenous peoples have increased GC incidence and mortality. 1 , 2 In collaboration with clinical and academic organizations, perform endoscopic campaigns focused on high-risk individuals (i.e., adults aged ≥50 years, male sex, smokers, family history of GC) and ideally symptomatic.…”

mentioning

confidence: 99%

“… 1 Across the Americas, Indigenous peoples have increased GC incidence and mortality. 1 , 2 In collaboration with clinical and academic organizations, perform endoscopic campaigns focused on high-risk individuals (i.e., adults aged ≥50 years, male sex, smokers, family history of GC) and ideally symptomatic. Treatments and referrals should be guaranteed through the available health system.…”

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confidence: 99%

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Recommendations for gastric cancer prevention and control in the Americas

Riquelme,

Abnet,

Goodman

et al. 2023

The Lancet Regional Health - Americas

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Sex and age differences in mortality trends of gastric cancer among Hispanic/Latino populations in the United States, Latin America, and the Caribbean

Cited by 4 publications

References 31 publications

Cancer mortality predictions for 2023 in Latin America with focus on stomach cancer

Cancer mortality predictions for 2023 in Latin America with focus on stomach cancer

Latin American young patients with gastric adenocarcinoma: worst prognosis and outcomes

Recommendations for gastric cancer prevention and control in the Americas

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