Sevoflurane-induced pica in female rats

Yamamoto, Kouichi; Yamamoto, Emiri; Sugimoto, Toru; Sagakami, Takuya; Yamatodani, Atsushi

doi:10.1016/j.jphs.2016.03.015

Cited by 8 publications

(11 citation statements)

References 14 publications

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“…Yamamoto et al previously showed that this pica behavior could not completely reflect gastrointestinal discomfort or emesis 14 . However, the same research group recently reported that female rats showed a greater intake of kaolin than male rats, and they determined that estrogen levels were involved in the development of kaolin pica behavior using bilaterally ovariectomized rats 15 . In humans, female sex was previously identified as the strongest PONV risk factor, 1,5 and our current and prior results 46 confirmed this (odds ratios: 14.7‐ and 7.15‐fold, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…Eating kaolin clay as a type of pica has been examined in recent animal studies as an alternative behavior to emesis 12–15 . One research group has reported the development of a rat pica model induced by cisplatin, an anticancer drug; in this model, the pattern of kaolin consumption appears to match the characteristics of cisplatin‐induced emesis in humans 16 .…”

Section: Introductionmentioning

confidence: 99%

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Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: Whole‐transcriptome profiling in the rat nucleus of the solitary tract

Sugino

Konno

Abe

et al. 2021

Genes Brain and Behavior

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The genetic mechanisms of postoperative nausea and vomiting (PONV) and the involvement of the catecholamine system in the brain have not been elucidated. Eating kaolin clay as a type of pica has been examined as an alternative behavior to emesis. Here, we evaluated changes in whole‐transcriptome analysis in the nucleus of the solitary tract (NTS) in a rat pica model as a surrogate behavior of PONV to elucidate the molecular genetic mechanisms of the development of PONV and the involvement of the catecholamine system in the NTS. First, kaolin pica behaviors were investigated in 71 female Wistar rats following isoflurane anesthesia, surgical insult or morphine administration. Multiple linear regression analysis showed that 3 mg/kg morphine increased kaolin intake by 2.8 g (P = 0.0002). Next, total RNA and protein were extracted from the dissected NTS, and whole‐transcriptome sequencing (RNA‐seq) was performed to identify PONV‐associated genes and to verify the involvement of the catecholamine system. The gene expression levels of tyrosine hydroxylase and dopamine beta‐hydroxylase in the catecholamine biosynthesis pathway decreased significantly in the PONV model. Release of noradrenaline, a catecholamine pathway end product, may have increased at the synaptic terminal of the NTS neuron after pica behavior. Systematic administration of α2 adrenergic receptor agonists after surgery reduced kaolin intake from 3.2 g (control) to 1.0 g (P = 0.0014). These results indicated that catecholamine neurotransmission was involved in the development of PONV in the NTS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: Whole‐transcriptome profiling in the rat nucleus of the solitary tract

Sugino

Konno

Abe

et al. 2021

Genes Brain and Behavior

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“…Previous studies reported that salivation, conditioned taste aversion, gaping, secretion of vasopressin, and gastric stasis are closely associated with the development of nausea (Andrews and Horn, 2006; Cabezos et al, 2008; Parker, 2014; Scallan and Simon, 2016), but it is difficult to accurately measure these parameters in laboratory animals under physiological conditions. We previously suggested that pica behavior in rats can be used as a method to assess gastrointestinal malaise including nausea (Yamamoto et al, 2014, 2015, 2016). The amount of kaolin intake in rats is proportional to the emetogenicity in humans (Yamamoto et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…One of the risk factors of chemotherapy-induced nausea and vomiting is considered to be a female sex (du Bois et al, 1992). We previously reported that female rats are more susceptible to the induction of sevoflurane-induced pica behavior than male rats (Yamamoto et al, 2016); thus, we used only female rats in a series of experiments. They were allowed free access to tap water and commercially available standard chow (CE-2, CLEA Japan, Inc., Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

“…Rats, one of the most common laboratory animals, have been considered unsuitable for the study of nausea and vomiting because they do not show a vomiting reflex (Hatcher, 1924). We previously reported that pica behavior, a behavior seen in rats characterized by eating non-nutritive materials, such as clay (kaolin), has been considered as a model of a nausea-like response or gastrointestinal malaise because it is induced by nauseant stimuli and the amount of kaolin intake is related to the nauseant severity in humans (Yamamoto et al, 2007, 2011, 2014, 2015, 2016). However, previous studies reported that it is difficult to evaluate their nausea-like response by the amount of kaolin intake, because rats subjected to marked stimuli showed decreased feeding and locomotive behaviors due to behavioral suppression (Malik et al, 2006, 2007; Cabezos et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Detection of Nausea-Like Response in Rats by Monitoring Facial Expression

2017

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Patients receiving cancer chemotherapy experience nausea and vomiting. They are not life-threatening symptoms, but their insufficient control reduces the patients’ quality of life. To identify methods for the management of nausea and vomiting in preclinical studies, the objective evaluation of these symptoms in laboratory animals is required. Unlike vomiting, nausea is defined as a subjective feeling described as recognition of the need to vomit; thus, determination of the severity of nausea in laboratory animals is considered to be difficult. However, since we observed that rats grimace after the administration of cisplatin, we hypothesized that changes in facial expression can be used as a method to detect nausea. In this study, we monitored the changes in the facial expression of rats after the administration of cisplatin and investigated the effect of anti-emetic drugs on the prevention of cisplatin-induced changes in facial expression. Rats were housed in individual cages with free access to food and tap water, and their facial expressions were continuously recorded by infrared video camera. On the day of the experiment, rats received cisplatin (0, 3, and 6 mg/kg, i.p.) with or without a daily injection of a 5-HT3 receptor antagonist (granisetron: 0.1 mg/kg, i.p.) or a neurokinin NK1 receptor antagonist (fosaprepitant: 2 mg/kg, i.p.), and their eye-opening index (the ratio between longitudinal and axial lengths of the eye) in the recorded video image was calculated. Cisplatin significantly and dose-dependently induced a decrease of the eye-opening index 6 h after the cisplatin injection, and the decrease continued for 2 days. The acute phase (day 1), but not the delayed phase (day 2), of the decreased eye-opening index was inhibited by treatment with granisetron; however, fosaprepitant abolished both phases of changes. The time-course of changes in facial expression are similar to clinical evidence of cisplatin-induced nausea in humans. These findings indicate that the monitoring of facial expression has the potential to be useful for the detection of a nausea-like response in laboratory animals.

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Isoflurane induces c-Fos expression in the area postrema of the rat

Hase

Hashimoto²,

Saitô

et al. 2019

J Anesth

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Volatile anesthetics are speculated to cause postoperative nausea and vomiting via stimulation of the chemoreceptor trigger zone (CTZ). However, the precise mechanism underlying the emetic action of these drugs is not well understood. In this study, we assessed whether isoflurane induced the expression of c-Fos, a neuronal activation marker, in the area postrema (AP), the locus of the CTZ, in rats, which do not have vomiting action. Male rats were exposed to 1.3% isoflurane for 0 to 240 min, or to various concentrations of isoflurane (0, 1.3%, or 2.6%) for 120 min.Finally, the rats were exposed to 1.3% isoflurane for 120 min after ondansetron administration. After the treatments, immunohistochemistry of the rat AP was performed using c-Fos antibody staining. One-way analysis of variance showed that isoflurane exposure significantly increased c-Fos expression in the AP; however, the rats pretreated with 4 mg/kg ondansetron showed significantly decreased c-Fos expression. Moreover, we evaluated the effect of the anesthetic on inducing pica in the rats, and found that kaolin intake was not influenced by isoflurane exposure.Overall, these results suggest that isoflurane activates AP neurons and may be involved in the emetic mechanism of isoflurane. This study further suggests the feasibility of using rats as a model for studying emetic mechanisms of drugs, despite their lack of vomit action.

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Sevoflurane-induced pica in female rats

Cited by 8 publications

References 14 publications

Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: Whole‐transcriptome profiling in the rat nucleus of the solitary tract

Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: Whole‐transcriptome profiling in the rat nucleus of the solitary tract

Detection of Nausea-Like Response in Rats by Monitoring Facial Expression

Isoflurane induces c-Fos expression in the area postrema of the rat

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