Sevoflurane attenuates myocardial ischemia/reperfusion injury by up-regulating microRNA-99a and down-regulating BRD4
Xiaomin Bie,
Jiying Ao,
Degang Zhu
Abstract:Purpose:
It has been explored that sevoflurane (Sevo) is cardioprotective in myocardial ischemia/reperfusion injury (MI/RI) and mediates microRNA (miRNA) expression that control various physiological systems. Enlightened by that, the work was programmed to decode the mechanism of Sevo and miR-99a with the participation of bromodomain-containing protein 4 (BRD4).
Methods:
MI/RImodel was established on mice. MI/RI modeled mice were exposed to Sevo or injected with miR-99a… Show more
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