Severity of Obstructive Sleep Apnea in Children With Sickle Cell Disease

Kaleyias, Joseph; Mostofi, Navid; Grant, Mitzie; Coleman, C.; Luck, Lori; Dampier, Carlton; Kothare, Sanjeev V.

doi:10.1097/mph.0b013e31817eb7ef

Cited by 77 publications

(82 citation statements)

References 44 publications

(39 reference statements)

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“…This result reflects the prevalence of OSAS in the general population of children and adolescents with SCA at a referral center. This result differs from that of the study conducted by Kaleyias et al, (3) who applied a questionnaire to 100 children, selected only the 19 most severe cases of suspected SDB to undergo polysomnography and concluded that 53% of the selected children had OSAS. In another study, (1) only 35% of the 20 patients studied were found to have OSAS.…”

Section: Discussioncontrasting

confidence: 55%

“…Children and adolescents with sleep apnea presented a significantly higher percentage of arousals during sleep. (3) In the present study, the frequency of nocturnal desaturation was increased (81.2%). A similar result was obtained by another group of authors, (3) who carried out a study using polysomnography and capnography.…”

Section: Discussionmentioning

confidence: 62%

“…In the same year, yet another group of authors, (3) also in 2008, applied a questionnaire to 100 children with SCA and selected the more severe cases (i.e., suspected cases of SDB) to undergo polysomnography. On the basis of what has been presented, we can state that the prevalence of OSAS in children and adolescents with SCA is unknown.…”

Section: Introductionmentioning

confidence: 99%

“…(2) In addition, approximately 80% of children with SCA present nocturnal desaturation, which might be the result of OSAS. (3) Few studies have attempted to estimate the prevalence of OSAS in children and adolescents with SCA. In addition, those studies had methodological limitations with regard to the populations studied, the number of patients in the samples and the diagnosis of OSAS, which is made through polysomnographic study.…”

Section: Introductionmentioning

confidence: 99%

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Prevalência da apneia obstrutiva do sono em crianças e adolescentes portadores da anemia falciforme

Salles¹,

Ramos

Daltro

et al. 2009

J. bras. pneumol.

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Objective: To estimate the prevalence of obstructive sleep apnea syndrome (OSAS) in children and adolescents with sickle cell anemia (SCA); to investigate the possible correlation between mean annual hemoglobin level and total sleep time with SpO 2 < 90%, as well as between mean annual hemoglobin level and total sleep time with SpO 2 < 80%; and to investigate the possible correlation between apnea-hypopnea index (AHI) and painful crisis. Methods: The study involved 85 patients with SCA. The patients completed a questionnaire, were submitted to polysomnography and underwent clinical evaluation (by a pediatrician and an otolaryngologist). An AHI > 1 was considered indicative of a diagnosis of OSAS. Results: The prevalence of OSAS was 10.6%. We found a negative correlation between mean annual hemoglobin level and total sleep time with SpO 2 < 90% (r = −0.343; p = 0.002), as well as between mean annual hemoglobin level and total sleep time with SpO 2 < 80% (r = −0.270; p = 0.016). There was no association between AHI and painful crisis. Conclusions: The prevalence of OSAS in this population was high (10.6%). Therefore, it is important to identify signs of OSAS as soon as possible and to determine the mean annual hemoglobin level because of the inverse correlation between that level and the total sleep time with SpO 2 < 90% or < 80%.Keywords: Prevalence; Sleep apnea, obstructive; Anemia, sickle cell; Polysomnography; Sleep apnea syndromes. ResumoObjetivo: Estimar a prevalência da síndrome da apneia obstrutiva do sono (SAOS) em crianças e adolescentes com anemia falciforme (AF) e investigar a possível correlação entre hemoglobina anual média e tempo total de sono com SpO 2 < 90% e tempo total de sono com SpO 2 < 80%, assim como investigar a possível correlação entre o índice de apneia-hipopneia (IAH) e episódios de crise álgica. Métodos: Participaram 85 pacientes com AF, que responderam a um questionário, foram avaliados por um pediatra e um otorrinolaringologista, e submetidos a estudo polissonográfico. O diagnóstico de SAOS foi definido como IAH > 1. Resultados: A prevalência da SAOS foi 10,6%. Observou-se uma correlação negativa entre hemoglobina anual média e tempo total de sono com SpO 2 < 90% (r = −0,343; p = 0,002) e tempo total de sono com SpO 2 < 80% (r = −0,270; p = 0,016). Não foi observada associação entre IAH e episódios de crise álgica. Conclusões: A prevalência da SAOS nesta população foi alta (10,6%). Portanto, é importante identificar precocemente os sinais de SAOS e avaliar hemoglobina anual média, devido à correlação inversa entre essa e o tempo total de sono com SpO 2 < 90% ou < 80%.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalência da apneia obstrutiva do sono em crianças e adolescentes portadores da anemia falciforme

Salles¹,

Ramos

Daltro

et al. 2009

J. bras. pneumol.

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“…Obstructive sleep apnea (OSA) is the commonest of these disorders [57]. Few studies have described sleep-disordered breathing and OSA in children and adolescent with SCA using polysomnography(PSG) [23,[58][59][60][61][62]. OSA was reported in 10-80% of children with Sickle cell disease [58][59][60][61][62]23].…”

Section: Ne and Sleep-related Disorders In Scamentioning

confidence: 99%

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Ahmed¹

2017

Med Surg Urol

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Children with sickle cell anemia (SCA) have a tendency to have nocturnal enuresis (NE) more than normal children with males being more affected than females. Mechanisms of NE that operate in normal children probably do so in children with SCA. Postulated causes of nocturnal enuresis in individuals with SCA include hyposthenuria causing nocturnal polyuria, reduced bladder capacity or nocturnal bladder overactivity, sleep disordered breathing and an increased arousal thresholds. The variation in the reported prevalence rate of NE in SCA is probably due to differences in definition criteria and methodology. This review will discuss the prevalence rate and postulated causes of NE in children with SCA.

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