Severity of allergic rhinitis and asthma development in children

Cara, Giuseppe Di; Carelli, Alessia; Latini, Arianna; Panfili, Eleonora; Bizzarri, Ilaria; Ciprandi, Giorgio; Buttafava, Serena; Frati, Franco; Verrotti, Alberto

doi:10.1186/s40413-015-0061-4

Cited by 20 publications

(14 citation statements)

References 15 publications

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“…In a previous Portuguese nationwide and population-based study, current wheezing showed a strong association with moderate to severe-persistent AR in preschool children 27. Another prospective study on children aged 6–12 years reported that the severity and duration of AR were significantly associated with asthma,28 which is comparable to our findings.…”

Section: Discussionsupporting

confidence: 91%

Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children According to the ARIA Classification

Jung

Lee

Yoon

et al. 2020

Allergy Asthma Immunol Res

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PurposeData are lacking on the association between the allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors and comorbidities, including sensitization to specific allergens and BHR, for the AR phenotype by AR and its Impact on Asthma (ARIA) classification in a general population-based birth cohort study.MethodsWe enrolled 606 children aged 7 years from the Panel Study of Korean Children. The AR phenotype was assigned in accordance with the ARIA classification in children. Skin prick tests and Provocholine provocation test were performed. Risk factors and comorbidities for AR phenotypes were then analyzed.ResultsThe prevalence of mild and moderate to severe AR in our study cohort was 37.2% and 8.8%, respectively. Recent use of analgesics or antipyretics and current cat ownership were associated with the risk of mild persistent AR. Sensitizations to Dermatophagoides Pteronyssinus (Der p), Japanese hop and cat were associated with moderate to severe persistent AR. Children with moderate to severe AR had a higher risk of current asthma and BHR compared to mild AR cases (adjusted odds ratio [aOR], 5.26; 95% confidence interval [CI], 1.77–15.62). Moderate to severe AR with allergic sensitization was associated with the highest risk of BHR (aOR, 11.77; 95% CI, 3.40–40.74).ConclusionsModerate to severe-persistent AR is more closely related to respiratory comorbidities and sensitizations than mild AR. Stratifying the AR phenotype by ARIA classification may assist in disease management.

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Section: Discussionsupporting

confidence: 91%

Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children According to the ARIA Classification

Jung

Lee

Yoon

et al. 2020

Allergy Asthma Immunol Res

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“…Thus, in Italy 24 patients (23.08 %) of 104 examined children with allergic rhinitis had a mild persistent course; this fact is consistent with our data [15]. In Spain, the moderate course of allergic rhinitis had 63% of the examined children, which is 12% less than our data, but the hypersensitivity to domestic dust mites was registered with a higher frequency and was equal to 61.9 % [16].…”

Section: Resultssupporting

confidence: 91%

Characteristics of domestic predictors of persistent bronchial asthma in adolescents and allergic rhinitis in children with a distal occlusion

Shumna

Nedelska

Fedosieieva

et al. 2018

ZMJ

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Характеристика побутових предикторів персистуючого перебігу бронхіальної астми у дітей-підлітків та алергічного риніту у дітей із дистальним прикусом Т. Є. Шумна, С. М. Недельська, О. С. Федосєєва, Т. П. Зінченко Мета роботи -визначення побутових предикторів розвитку бронхіальної астми в дітей-підлітків та алергічного риніту в дітей із дистальним прикусом, що мали персистуючий клінічний перебіг захворювання.Матеріали та методи. Здійснили клініко-анамнестичне та алергологічне дослідження 87 дітей підліткового віку (від 13 до 17 років). У І групу спостереження ввійшли 34 підлітки із персистуючим перебігом бронхіальної астми, ІІ групу -28 дітей із персистуючим алергічним ринітом і дистальним прикусом, які додатково лікували супутню зубощелепо-лицьову патологію в лікаря-ортодонта. Контрольна група спостереження (ІІІ) -25 здорових дітей. Співвідношення хлопчиків і дівчаток у групах спостереження та контролю було однаковим (р > 0,05). За анкетуванням вивчили анамнестичні дані щодо побутових умов проживання, соціально-гігієнічний стан житла: наявність домашніх тварин, частоту та особливості використання певних хімічних мийних і косметичних засобів у дітей. Проаналізували клінічний перебіг захворювань. Під час диспансерного спостереження в періоді ремісії дітям із персистуючим перебігом бронхіальної астми та алергічного риніту за відсутності протипоказань до тестування in vivo з алергенами виконали алергологічне дослідження шляхом постановки шкірних прик-тестів із побутовими й епідермальними алергенами виробництва ТОВ «Імунолог» (м. Вінниця). Порівнюючи статистичні сукупності, використовували непараметричний статистичний метод «2×2 Table», the Chi-square (df = 1) та розраховували відношення шансів (ВШ) з використанням чотирьохпільної таблиці з розрахунком довірчого інтервалу (ДІ) за методом Woolf. З використанням непараметричного методу gamma correlation (рекомендується використовувати, коли в даних є багато значень, котрі збігаються) виконали аналіз зв'язку між показниками гіперчутливості до алергенів. Розбіжності р < 0,05 при порівнянні показників у групах спостереження та контрольній вважали статистично вірогідними.Результати. Персистуючий перебіг хронічного алергічного респіраторного синдрому середнього ступеня тяжкості вірогідно частіше реєстрували в дітей з алергічним ринітом і дистальним прикусом (75,00 %), ніж у підлітків із бронхіальною астмою Purpose. Determination of domestic predictors of bronchial asthma in adolescents and allergic rhinitis in children with distal occlusion who have a persistent clinical course of the disease. Materials and methods.A clinical, anamnestic and allergic examination of 87 adolescents aged 13 to 17 years has been conducted. Of them, 34 adolescents with persistent bronchial asthma were considered as the first monitoring group (І); the group II included 28 children with persistent allergic rhinitis and distal occlusion, thereby they additionally received orthodontic treatment for faciomaxillary pathology. The control group (ІІІ) consisted of 25 healthy children. The ratio of boys...

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“…Few former studies in this emerging scientific field, have reported that children with asthma and AR exhibit poorer asthma control and higher risk of exacerbations, impaired life quality and increased healthcare cost compared to individuals without AR ( 5 , 31 , 32 ). Of note, nearly 80% of children with asthma exhibit concomitant AR, and ~40% with AR exhibit concomitant asthma ( 5 , 6 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

Association of Asthma and Allergic Rhinitis With Sleep-Disordered Breathing in Childhood

et al. 2018

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Objective: Asthma and allergic rhinitis (AR) are the most common chronic conditions in childhood and have previously been linked to sleep-related breathing disorder (SRBD). Aim of the study was to examine the association between SRBD risk and asthma control in children with asthma and with or without AR.Methods: The assessment of FeNO and pulmonary function tests were performed in 140 children (65 with asthma, 57 with both asthma, and AR, 18 with only AR). Children with asthma completed the childhood Asthma Control Test (c-ACT), and the Sleep-Related Breathing Disorder scale, extracted from the Pediatric Sleep Questionnaire (PSQ). C-ACT scores ≤ 19 are indicative of poor asthma control whereas SRBD from PSQ scores ≥ 0.33 are suggestive of high risk for SRBD.Results: Mean age ± SD was 7.8 ± 3.1 years. Mean PSQ ± SD and c-ACT ± SD scores were 0.17 ± 0.14 and 24.9 ± 3.2, respectively. High risk for SRBD was identified in 26 children. Children at high risk for SRBD had significantly decreased c-ACT score (P = 0.048), verified by a negative association between c-ACT and PSQ-SRBD scores (r = −0.356, P < 0.001). Additionally a difference in diagnosis distribution between children at high or low risk for SRBD was observed. More specifically, among children at high risk, 88.5% were diagnosed with both atopic conditions, while this percentage among children at low risk was 29.8%. Asthma was mainly diagnosed in the latter group (P < 0.001).Conclusions: Poor asthma control is associated with SRBD. The presence of AR in children with asthma seems to increase the prevalence of SRBD in that particular population, requiring further investigation toward this direction.

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Severity of allergic rhinitis and asthma development in children

Cited by 20 publications

References 15 publications

Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children According to the ARIA Classification

Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children According to the ARIA Classification

Characteristics of domestic predictors of persistent bronchial asthma in adolescents and allergic rhinitis in children with a distal occlusion

Association of Asthma and Allergic Rhinitis With Sleep-Disordered Breathing in Childhood

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