Severity Assessment and Outcome Measures in Acne Vulgaris

Zarchi, Kian; Jemec, Gregor B. E.

doi:10.1007/s13671-012-0016-8

Cited by 10 publications

(8 citation statements)

References 30 publications

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“…There are many tools to assess acne severity, but none of them considered as a universally accepted one. 19,20 Furthermore, they are not interchangeable as they do not measure the same components of the disease. Measuring disease severity is essential for clinical practice in terms of evaluation and follow-ups, and in comparing studies in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…The mean score for CADI was (4.52 ± 2.919), and DLQI was (3.78 ± 4.17). For the DLQI, the majority of study population acne has either no effect (19,35.2%) or only a small effect (22, 40.7%) on patient life. Similarly, the majority of study population acne caused mild impairment of quality of life (34, 63%) or moderate impairment (14, 25.9%), as shown in Table 2.…”

Section: Cadi and Dlqimentioning

confidence: 97%

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<p>Severity of Acne Vulgaris: Comparison of Two Assessment Methods</p>

Alsulaimani

Kokandi

Khawandanh

et al. 2020

CCID

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Purpose: Numerous tools are available to assess acne severity. It is important to have an acceptable and easy to use tool for acne assessment for many reasons, such as initial assessment and follow-ups, clinical trials, and comparisons of clinical studies. The aim was to investigate the agreement between different observers (inter-observer variation) in the evaluation using the Global Acne Grading System (GAGS) and Investigator Global Assessment of Acne (IGA). Besides, to investigate the correlation between the assessment scores and its relation to the quality of life scales Dermatology Life Quality Index (DLQI) and the Cardiff Acne Disability Index (CADI). Patients and Methods: This was a prospective study. Four investigators involved to evaluate the study subject surveyed 54 patients complaining of acne using IGA and GAGS scores (DLQI and CADI). Results: A significant relation was seen between GAGS and IGA (Pearson chi-square test p= 0.001), and they demonstrated excellent inter-rater reliability. There was no correlation between IGA and quality of life measures (CADI nor DLQI). However, there was a significant weak correlation between GAGS and CADI. Conclusion: The two methods for acne severity assessment are reliable, and they are correlated. Quality of life concerning acne is not correlated with the severity of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Cadi and Dlqimentioning

confidence: 97%

<p>Severity of Acne Vulgaris: Comparison of Two Assessment Methods</p>

Alsulaimani

Kokandi

Khawandanh

et al. 2020

CCID

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“…3 In clinical trials investigating acne treatments, multiple outcome measures have been used with no established standards. 4,5 This multiplicity, heterogeneity and lack of quality have been problematic in data synthesis by impeding comparative outcomes research and contributing to resource wastage. An international consensus on a core outcome set for clinical trials in acne could address this unmet need by standardizing and harmonizing existing outcome measures, and identifying those that might be lacking.…”

mentioning

confidence: 99%

“…In clinical trials investigating acne treatments, multiple outcome measures have been used with no established standards 4,5 . This multiplicity, heterogeneity and lack of quality have been problematic in data synthesis by impeding comparative outcomes research and contributing to resource wastage.…”

mentioning

confidence: 99%

Identifying and appraising patient‐reported outcome measures on treatment satisfaction in acne: a systematic review*

Zuuren

Arents²,

Miklas

et al. 2020

Br J Dermatol

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Background After dermatitis, acne is the next skin disease to contribute most to the burden of skin diseases worldwide. Recently, seven core outcome domains have been identified, which together form an Acne Core Outcome Set (ACORN). One of these was satisfaction with acne treatment. Objectives To identify studies that described the development of patient-reported outcome measures (PROMS), evaluated one or more measurement properties of a PROM, or evaluated the interpretability of a PROM in patients with acne regarding treatment satisfaction. Methods The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) search strategy for identifying PROMS on acne treatment satisfaction was used. We searched PubMed, MEDLINE, Embase, LILACS, Web of Science, Cochrane Library, Emcare, PsycINFO and Academic Search premier (June 2020). Study selection, data extraction and assessment of methodological quality according to COSMIN guidance were carried out independently by two authors. Results Only one study could be included, describing the development of a treatment satisfaction measure in patients with acne. The development was assessed as inadequate and data on measurement properties were lacking. Additionally, we found 188 studies reporting treatment satisfaction solely as an outcome, using a wide variety of methods, none of them standardized or validated. Conclusions We could not find a PROM on treatment satisfaction to recommend for a core outcome set in acne. There is an unmet need for a PROM on treatment satisfaction in acne that is robustly developed, designed and validated.What is already known about this topic?• Core outcome sets are consensus-based minimum outcome measures that should be reported in clinical trials of a specific disease or target condition.

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“…Various global assessments are used to assess acne severity in clinical trials, including the Evaluator’s Global Severity Score (EGSS), Investigator’s Global Assessment (IGA), and Global Acne Assessment Score (GAAS), with ratings ranging from ‘clear’ to ‘severe’ or ‘very severe’ [ 40 ]. Similarly subjective scales have also been used to assess hyperpigmentation, such as an adaptation of IGA with scores/ratings ranging from 0 = ‘clear of hyperpigmentation’ to 5 = ‘very severe hyperpigmentation (very dark brown, almost black in quality)’ [ 41 ] and a cutaneous safety instrument (used in acne clinical trials) that includes a hyperpigmentation item with scores/ratings ranging from 0 = ‘none, no evidence’ to 3 = ‘severe, marked/prominent’ [ 37 ].…”

Section: Assessing Acne and Hyperpigmentation In Patients With Skin Of Color (Soc)mentioning

confidence: 99%

Effects of Topical Retinoids on Acne and Post-inflammatory Hyperpigmentation in Patients with Skin of Color: A Clinical Review and Implications for Practice

et al. 2021

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Acne is a common cause for post-inflammatory hyperpigmentation (PIH), particularly in patients with skin of color (SOC), and PIH is often more distressing to patients than the acne itself. Topical retinoids are approved for the treatment of acne and for pigmentation disorders such as melasma or mottled hyperpigmentation associated with photodamage; moreover, they have been shown to reduce hyperpigmentation in patients with SOC. Therefore, treatment with topical retinoids should be started as early as possible unless contraindicated. Use of novel formulations or application of commonly recommended moisturizers may help reduce irritation. Combining retinoids with other topical agents and procedures such as superficial chemical peels can help to improve hyperpigmentation. Primary acne lesions are likely to improve weeks before PIH resolves and helping patients manage their expectations may reduce frustration. Providing clinicians and researchers with more education about the presentation and management of dermatologic conditions in patients with SOC is also recommended.

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Severity Assessment and Outcome Measures in Acne Vulgaris

Cited by 10 publications

References 30 publications

<p>Severity of Acne Vulgaris: Comparison of Two Assessment Methods</p>

<p>Severity of Acne Vulgaris: Comparison of Two Assessment Methods</p>

Identifying and appraising patient‐reported outcome measures on treatment satisfaction in acne: a systematic review*

Effects of Topical Retinoids on Acne and Post-inflammatory Hyperpigmentation in Patients with Skin of Color: A Clinical Review and Implications for Practice

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