Infectious Disease Clinics of North America volume 22, issue 1, P1-31 2008 DOI: 10.1016/j.idc.2007.09.005 View full text
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David A. Talan, Gregory J. Moran, Fredrick M. Abrahamian

Abstract: Increased attention has focused recently on the acute management of severe sepsis and septic shock, conditions that represent the end-stage systemic deterioration of overwhelming infection. Clinical trials have identified new therapies and management approaches that, when applied early, appear to reduce mortality. Practice guidelines have been advanced by critical care societies, and many of the proposed interventions involve therapies other than antimicrobials directed at hemodynamic resuscitation or addressi…

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