Severe Seoul hantavirus infection in a pregnant woman, France, October 2012

Macé, G.; Feyeux, C; Mollard, N.; Chantegret, C; Audia, Sylvain; Rebibou, Jean-Michel; Spagnolo, G; Bour, J. B.; Denoyel, G. A.; Sagot, P.; Reynes, Jean‐Marc

doi:10.2807/ese.18.17.20464-en

Cited by 42 publications

(9 citation statements)

References 14 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We recovered seven complete and semi-complete genomes of SEOV from these wild rats, which greatly increase the genetic data available on SEOV from France, especially for the M and L segments. The recovered genomes were significantly larger in contrast to the previous studies (11)(12)(13). Genetic analyses showed high identity levels between all these (which was not certified by peer review) is the author/funder.…”

Section: Discussionmentioning

confidence: 74%

“…The presence of SEOV in France has been detected in both humans and rats previously (11,12). The first SEOV-HFRS case detected in Europe, confirmed by molecular evidence, was found in a pregnant woman from Replonges (12), a locality close to Lyon, a densely populated city with over 500,000 inhabitants in France. Since then, several studies have demonstrated SEOV circulation in Lyon city area.…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Evolution and Genetic Characterization of Seoul Virus in Wild RatsRattus Norvegicusfrom an urban park in Lyon, France 2020-2022

Alburkat

Smura

Bouilloud

et al. 2023

Preprint

View full text Add to dashboard Cite

Seoul virus (SEOV) is an orthohantavirus primarily carried by rats that can cause hemorrhagic fever with renal syndrome (HFRS) in humans. Nowadays, its incidence is likely underestimated. We developed a comprehensive serological and molecular characterization of SEOV in Rattus norvegicus population from a popular urban park within a large city (Park of La Tete dOr, Lyon, France) between 2020 and 2022. We confirmed the circulation of SEOV in rats from the park (seroprevalence 17.2%). The SEOV strains detected showed high genetic similarity with the strain previously described in 2013 in this area. We found low structuring of wild rat populations within Lyon city. This study confirms the circulation of SEOV in Lyon city, in a park where opportunities for SEOV transmission to humans are numerous. Given the high gene flow between rat populations in the park and the rest of the city, we recommend conducting city-wide SEOV surveillance.

show abstract

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 90%

Evolution and Genetic Characterization of Seoul Virus in Wild RatsRattus Norvegicusfrom an urban park in Lyon, France 2020-2022

Alburkat

Smura

Bouilloud

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…More importantly, close monitoring of fetal life signs and the appreciation of obstetric disposition are pivotal to both the mother and fetus during pregnancy. By reviewing the previous literature, we found that four pregnant women with HFRS were complicated with severe fetal adverse events but still recovered fully after terminating the pregnancy ( 13 , 15 , 16 , 33 ). Of the three pregnant women experiencing intrauterine fetal death in current study, the two patients who selected timely termination recovered completely; However, the remaining patient refused to terminate pregnancy and subsequently died of DIC.…”

Section: Discussionmentioning

confidence: 98%

“…The incidence of adverse fetal events was more likely related to the severe status of pregnant women with HFRS. Previous literature showed that the cases with fetal adverse events were all classified into severe or critical type ( 13 , 15 , 16 ). In current cohort, three cases resulted in intrauterine fetal death.…”

Section: Discussionmentioning

confidence: 99%

“…This is because of the scarcity of case reports describing HFRS in pregnancy, a condition that poses significant difficulties for clinical management. In addition, inconsistent maternal and fetal outcomes have been reported previously (12)(13)(14)(15)(16)(17). In previous case reports, results indicated that hantavirus infection in pregnant women resulted in serious effects on maternal and fetal outcomes, such as intrauterine fetal distress, death, abortion, or neonate death (18).…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

The Clinical Characteristics and Outcomes of Hemorrhagic Fever With Renal Syndrome in Pregnancy

Ren

et al. 2022

Front. Med.

View full text Add to dashboard Cite

Pregnant women with hemorrhagic fever with renal syndrome (HFRS) are a significant challenge for clinicians. The clinical characteristics of HFRS in pregnant women and its influence on both the pregnant women and fetus have yet to be clarified clearly. To highlight the specific clinical features of HFRS in pregnant women and the outcomes of pregnant women with HFRS and their fetuses, we screened pregnant women with HFRS from inception to May 1st 2021. We also conducted a comparison with non-pregnant women complicated with HFRS. Twenty-seven pregnant women and 87 non-pregnant women with complete electronic medical records were enrolled for final analyses; 55.6% (15/27) and 21.8% (19/87) were diagnosed as critical type in pregnant women and non-pregnant women, respectively. Compared with non-pregnant patients, there was a significantly higher likelihood of critical status in pregnant patients; the risk was significantly higher in late trimester (p <0.001). In addition, hypoalbuminemia and anemia were also evident in pregnant patients (p = 0.04, p <0.001, respectively). Leukocyte count, especially when higher than 15 × 109/L, was significantly correlated with disease severity (p = 0.009). After comprehensive therapy, 26 pregnant patients recovered without sequelae. Five fetal adverse events were reported during hospitalization. All adverse events were observed in mothers with critical types (p = 0.047, X2 = 4.909) and occurred in the later trimester. Collectively, our data show that pregnant woman with HFRS during the third trimester presents a more severe condition, especially those with leukocytosis. However, the majority of those pregnant patients could recover with comprehensive treatment and undergo normal labor.

show abstract