Severe Disseminated Cutaneous Gout

‘Golden Kernels within the skin’: disseminated cutaneous gout

“…These lesions eventually became infected and were misdiagnosed as common skin infection. Similar cases were presented by Ebner et al 10 and Orzan et al 11…”

Disseminated cutaneous gout: a rare manifestation of a common disease

“…The pathogenesis is poorly understood. In our review of 23 reported cases of extensive extra-articular dermal/subcutaneous tophi (including the present case), [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18], the majority of patients were male (87%) and Asian (57%), (Table 1). There was fairly equal representation from Asian countries with high gout prevalence (Taiwan) as well as those with low prevalence (China, South Korea, Philippines, Vietnam), [19].…”

“…Uric acid-lowering therapy with allopurinol has been reported to decrease the size and number of tophi in around one-third of patients with disseminated cutaneous gout. However, it is important to inform patients that improvement may occur gradually over years [4,16,18]. Surgical excision could be considered for tophi causing nerve compression or limiting mobility.…”

The Importance of European Funded Projects for the Development of a Tourist Destination Case study – North-West Region of Romania (North Transylvania)

“…In this way, the digital environment enables marketers to consider, in addition to the four components of the marketing mix (product, price, distribution and promotion), two specific components of the online area: interactivity and how to achieve the data as database systems data (Orzan G., Orzan M., 2007). These two components customize online, offering professionals the opportunity to develop the activities they undertake.…”