Setting Research Priorities To Reduce Global Mortality from Childhood Diarrhoea by 2015

Fontaine, Olivier; Kosek, Margaret; Bhatnagar, Shinjini; Boschi-Pinto, Cynthia; Chan, Kit Yee; Duggan, Christopher; Martı́nez, Homero; Ribeiro, Hugo da Costa; Rollins, Nigel; Salam, Mohammed Abdus; Santosham, Mathuram; Snyder, John; Tsai, Alexander C.; Vargas, Beth; Rudan, Igor

doi:10.1371/journal.pmed.1000041

Cited by 73 publications

(69 citation statements)

References 8 publications

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“…Although this paper describes the first application of the CHNRI method to health problems affecting adolescents, more than 50 similar applications have been undertaken among various populations to prioritize research outcomes in other areas of health. [15][16][17][18][19][20][21] We implemented the CHNRI approach in three phases. In Phase 1, we asked research and programme experts to rank 10 health outcome areas in order of importance.…”

Section: Methodsmentioning

confidence: 99%

Setting research priorities for adolescent sexual and reproductive health in low- and middle-income countries

Hindin

Christiansen

Ferguson

2012

Bull. World Health Organ.

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Section: Methodsmentioning

confidence: 99%

Setting research priorities for adolescent sexual and reproductive health in low- and middle-income countries

Hindin

Christiansen

Ferguson

2012

Bull. World Health Organ.

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“…Hence the World Health Organization (WHO) has initiated a set of global research priority–setting exercises in 2007–2008 for improving health of mothers, newborns, children and adolescents [8–12]. The five–year evaluation of that exercise from the perspective of donors, policy–makers and researchers is currently under way and it is showing an increased focus on identified research priorities from all three groups of stakeholders – in terms of investments by the donors [13,14], initiatives launched by policy–makers [15–19] and publication output from researchers [2,20–23], respectively.…”

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confidence: 99%

Structure, function and five basic needs of the global health research system

Yoshida¹,

Martines²,

Lawn³

et al. 2015

Journal of Global Health

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BackgroundIn 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013–2025.MethodsWe used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.ResultsNine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.ConclusionThese findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

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“…Figure 1 shows how the steering committee identified relevant research questions from existing Child Health and Nutrition Research Initiative studies. [11][12][13][14][15][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The final list from the literature contained 45 research questions. Thirtyeight experts were then formally invited by email to participate.…”

Section: Discussionmentioning

confidence: 99%

Setting an implementation research agenda for Canadian investments in global maternal, newborn, child and adolescent health: a research prioritization exercise

et al. 2017

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Background: Improving global maternal, newborn, child and adolescent health (MNCAH) is a top development priority in Canada, as shown by the $6.35 billion in pledges toward the Muskoka Initiative since 2010. To guide Canadian research investments, we aimed to systematically identify a set of implementation research priorities for MNCAH in low-and middle-income countries. Methods:We adapted the Child Health and Nutrition Research Initiative method. We scanned the Child Health and Nutrition Research Initiative literature and extracted research questions pertaining to delivery of interventions, inviting Canadian experts on MNCAH to generate additional questions. The experts scored a combined list of 97 questions against 5 criteria: answerability, feasibility, deliverability, impact and effect on equity. These questions were ranked using a research priority score, and the average expert agreement score was calculated for each question. Results:The overall research priority score ranged from 40.14 to 89.25, with a median of 71.84. The average expert agreement scores ranged from 0.51 to 0.82, with a median of 0.64. Highly-ranked research questions varied across the life course and focused on improving detection and care-seeking for childhood illnesses, overcoming barriers to intervention uptake and delivery, effectively implementing human resources and mobile technology, and increasing coverage among at-risk populations. Children were the most represented target population and most questions pertained to interventions delivered at the household or community level.Interpretation: Investing in implementation research is critical to achieving the Sustainable Development Goal of ensuring health and well-being for all. The proposed research agenda is expected to drive action and Canadian research investments to improve MNCAH. Abstract ResearchResearch CMAJ OPEN CMAJ OPEN, 5(1) E83

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Setting Research Priorities To Reduce Global Mortality from Childhood Diarrhoea by 2015

Abstract: Olivier Fontaine and colleagues applied a priority-setting methodology to identify research priorities aimed at reducing global diarrhea mortality by 2015.

Cited by 73 publications

References 8 publications

Setting research priorities for adolescent sexual and reproductive health in low- and middle-income countries

Setting research priorities for adolescent sexual and reproductive health in low- and middle-income countries

Structure, function and five basic needs of the global health research system

Setting an implementation research agenda for Canadian investments in global maternal, newborn, child and adolescent health: a research prioritization exercise

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