Serum α2-HS glycoprotein concentration in patients with hematological malignancies

Abstract

We observed significantly reduced serum alpha 2-HS glycoprotein concentrations in patients with acute lymphocytic, acute nonlymphocytic, chronic granulocytic and chronic myelomonocytic leukemias, Hodgkin's and non-Hodgkin's lymphomas, myelofibrosis, and multiple myeloma, but not in patients with chronic lymphocytic leukemia and polycythemia vera, as compared with healthy controls. We followed the serum level of the protein for 18 months. Patients with infectious complications, those receiving cytostatic treatment, and those in the preterminal period had further reduced serum alpha 2-HS glycoprotein levels. The reduction of serum alpha 2-HS glycoprotein concentration was primarily due to decreased production caused by infiltration of the liver, a hepatotoxic effect of cytostatic treatment, and, to a lesser degree, to increased consumption. We found statistically significant negative correlations between serum alpha 2-HS glycoprotein concentration and erythrocyte sedimentation rate, serum aspartate aminotransferase and alkaline phosphatase activities, and IgG and IgM concentrations. The determination of the alpha 2-HS glycoprotein concentration is useful for the assessment and follow-up of the clinical status and therapy of patients with hematological malignancies and also has prognostic significance.

Preeclampsia is associated with decreased serum α2-HS glycoprotein (fetuin-A) concentration

“…30,31 Furthermore, an increased consumption was also supposed to result in reduced serum AHSG levels in patients with hematological malignancies. 32 In pregnancy, the fetoplacental unit can be another source of the protein. Indeed, AHSG is highly expressed in placental tissues, and a passive transplacental transfer of this substance Decreased serum a 2 -HS glycoprotein level in preeclampsia A Molvarec et al has also been suggested.…”

“…In fact, circulating AHSG levels decrease in several conditions characterized by tissue damage, infection, inflammation or malignancy. 16,32,[36][37][38] However, other factors may also have contributed to our observation. It has been shown earlier that AHSG enhances the macrophage-mediated phagocytosis of apoptotic cells in vitro by stimulating macropinocytosis.…”

Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes

“…AHSG is considered as a negative acute phase reactant, the concentration of which decreases during infections, trauma and liver cirrhosis (15)(16)(17). It is tempting to speculate on the biological significance of this protein in clinical settings where its concentration increases, i.e.…”

Fetuin (α2-HS-glycoprotein) opsonizes cationic macrophagedeactivating molecules

“…Decreased levels of human fetuin have been observed in patients with acute lymphocytic leukemia, Hodgkin's and non-Hodgkin's lymphomas, rheumatoid arthritis, acute alcoholic hepatitis, chronic active hepatitis, acute and chronic pancreatitis, inflammatory bowel disease, and trauma (22,43). Under conditions where macrophage-associated fetuin levels are decreased, macrophage deactivation by endogenous counter-regulators may be impaired, leading to uncontrolled overproduction of proinflammatory cytokines.…”