Serum vitamin D levels in patients with obstructive sleep apnea syndrome and level changes after continuous positive airway pressure therapy

Siachpazidou, Dimitra; Kotsiou, Ourania S.; Stavrou, Vasileios; Pastaka, Chaido; Gogou, Evdoxia; Kechagia, Maria; Varsamas, Charalampos; Economou, Nicholas-Tiberio; Zouridis, Spyridon; Patrikioy, Eleni; Seitanidis, George; Pinaka, Maria; Sistou, Alexandra; Hatzoglou, Chrissi; Gourgoulianis, Konstantinos

doi:10.1007/s11325-020-02146-6

Cited by 8 publications

(12 citation statements)

References 34 publications

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“…The use of vitamin D3 reduced protein expression, transcriptional activity, and target genes of HIF1‐α in various human cancer cells, 57 substantiating the relationship between vitamin D deficiency and hypoxia. This is further proven with clinical studies, which demonstrated improvement of vitamin D level with attenuation of hypoxia in patients with OSA treated adequately with CPAP therapy 38–41 …”

Section: Possible Mechanismsmentioning

confidence: 86%

“… 24 , 25 Although few studies found no significant difference in vitamin D level between these two cohorts, these studies still demonstrated that the number of patients with vitamin D deficiency, especially at a level of <10 mcg/dL, was higher in the OSA group, and more pronounced with increasing disease severity, compared with those without OSA. 22 , 28 , 29 …”

Section: Clinical Studies Of Osa and Vitamin Dmentioning

confidence: 99%

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Obstructive sleep apnea and vitamin D level: Has the dust settled?

Loh

Sukor

2023

Clinical Respiratory J

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Obstructive sleep apnea and vitamin D deficiency are associated with multiple complications with increased morbidity and mortality. However, the relationship between these two entities remains unclear, with clinical studies demonstrating contradictory results. This narrative review aims to present the current evidence and understanding of this relationship and discuss the possible mechanisms linking these two disease entities. Finally, we summarize and propose areas of opportunity for future research.

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Section: Possible Mechanismsmentioning

confidence: 86%

Section: Clinical Studies Of Osa and Vitamin Dmentioning

confidence: 99%

Obstructive sleep apnea and vitamin D level: Has the dust settled?

Loh

Sukor

2023

Clinical Respiratory J

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“…The definition of Vit D status in OSA patients remained controversial for a long time, with some studies reporting decreased Vit D levels in those patients while others concluded otherwise [ 22 , 23 , 24 , 25 ]. A meta-analysis conducted by Neighbors et al, [ 26 ] including 14 studies with 1513 controls and 3424 OSA patients, reported decreased Vit D serum levels in the latter, with Vit D insufficiency being incrementally exacerbated with increasing severity of OSA (mean differences were −2.7% for mild OSA, −10.1% for moderate OSA and −17.4% for severe OSA).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Levels in Patients with Overlap Syndrome, Is It Associated with Disease Severity?

Archontogeorgis

Voulgaris

Nena

et al. 2022

JPM

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Background: The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) has been defined as overlap syndrome (OVS). Recently, a link between OSA, COPD and Vitamin D (Vit D) serum concentration was reported, however, evidence regarding Vit D status in patients with OVS is scarce. The aim of the present study was to evaluate Vit D serum levels and to explore the association of those levels with anthropometric, pulmonary function and sleep parameters in patients with OVS. Methods: Vit D serum levels were measured in patients diagnosed with OVS, as confirmed by overnight polysomnography and pulmonary function testing. Results: A total of 90 patients (79 males and 11 females) were included in the analysis. The patients were divided into three groups matched for age, gender, and BMI: the control group that included 30 patients (27 males and 3 females), the OSA group that included 30 patients (26 males and 4 females), and the OVS group that included 30 patients (26 males and 4 females). Patients with OVS exhibited decreased serum 25(OH)D levels compared with OSA patients and controls (14.5 vs. 18.6 vs. 21.6 ng/mL, p < 0.001). In the OVS group, multiple linear regression analysis identified AHI and FEV1, as predictors of serum 25(OH)D levels (p = 0.041 and p = 0.038, respectively). Conclusions: Lower Vit D levels have been observed in patients with OVS compared with OSA patients and non-apneic controls, indicating an increased risk of hypovitaminosis D in this population which might be associated with disease severity.

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“…Finally, OSAS patients present low vitamin-D levels. The low vitamin-D levels have been associated with multiple cardiovascular disorders, nervous system disorders (multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's, and Alzheimer's), while CPAP treatment may increase vitamin-D levels OSAS patients (50,51).…”

Section: Insulin -Resistant Syndromes and Pro-inflammatory Pronenessmentioning

confidence: 99%

Obstructive Sleep Apnea Syndrome: The Effect of Acute and Chronic Responses of Exercise

et al. 2021

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Obstructive Sleep Apnea Syndrome (OSAS) is a sleep disorder with high prevalence in general population, but alarmingly low in clinicians' differential diagnosis. We reviewed the literature on PubMed and Scopus from June 1980–2021 in order to describe the altered systematic pathophysiologic mechanisms in OSAS patients as well as to propose an exercise program for these patients. Exercise prevents a dysregulation of both daytime and nighttime cardiovascular autonomic function, reduces body weight, halts the onset and progress of insulin resistance, while it ameliorates excessive daytime sleepiness, cognitive decline, and mood disturbances, contributing to an overall greater sleep quality and quality of life.

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Serum vitamin D levels in patients with obstructive sleep apnea syndrome and level changes after continuous positive airway pressure therapy

Cited by 8 publications

References 34 publications

Obstructive sleep apnea and vitamin D level: Has the dust settled?

Obstructive sleep apnea and vitamin D level: Has the dust settled?

Vitamin D Levels in Patients with Overlap Syndrome, Is It Associated with Disease Severity?

Obstructive Sleep Apnea Syndrome: The Effect of Acute and Chronic Responses of Exercise

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