Serum uric acid was an independent predictor of mortality in ST-segment elevation myocardial infarction patients with Killip I other than Killip II-IV Comment on "J Cardiovasc Thorac Res 2016;8:56-60"

Li, Chengwei; Lin, Tzu-Chiao

doi:10.15171/jcvtr.2017.10

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…We previously reported that elevated serum uric acid was associated with the prevalence of metabolic syndrome, left ventricular hypertrophy, left ventricular diastolic dysfunction in various study populations such as apparently healthy individuals, patients with cardiometabolic abnormalities, and patients with ST-segment elevation myocardial infarction [29][30][31][32]. However, we did not find a significant association between hyperuricemia and MACE and MALE in the present study.…”

Section: Plos Onecontrasting

confidence: 88%

Neutrophil-to-lymphocyte ratio associated with an increased risk of mortality in patients with critical limb ischemia

Liu

2021

PLoS ONE

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Purpose Association of the neutrophil-to-lymphocyte ratio (NLR) with mortality has not been comprehensively explored in critical limb ischemia (CLI) patients. We investigated the association between the NLR and clinical outcomes in CLI. Materials and methods We retrospectively enrolled consecutive CLI patients between 1/1/2013 and 12/31/2018. Receiver operating characteristic curve analysis determined NLR cutoffs for 1-year in-hospital, all-cause and cardiac-related mortality; major adverse cardiovascular events (MACEs); and major adverse limb events (MALEs). Results Among 195 patients (age, 74.0 years, SD: 11.5; 51.8% male; body mass index, 23.4 kg/m2, SD: 4.2), 14.4% exhibited acute limb ischemia. After 1 year, patients with NLR>8 had higher in-hospital mortality (21.1% vs. 3.6%, P<0.001), all-cause mortality (54.4% vs. 13.8%, P<0.001), cardiac-related mortality (28.1% vs. 6.5%, P<0.001), MACE (29.8% vs. 13.0%, P = 0.008), and MALE (28.1% vs. 13.0%, P = 0.021) rates than those with NLR<8. In multivariate logistic regression, NLR≥8 was significantly associated with all-cause (P<0.001) and cardiac-related (adjusted HR: 5.286, 95% CI: 2.075–13.47, P<0.001) mortality, and NLR≥6 was significantly associated with MALEs (adjusted HR: 2.804, 95% CI: 1.292–6.088, P = 0.009). Each increase in the NLR was associated with increases in all-cause (adjusted HR: 1.028, 95% CI: 1.008–1.049, P = 0.007) and cardiac-related (adjusted HR:1.027, 95% CI: 0.998–1.057, P = 0.073) mortality but not in-hospital mortality or MACEs. Conclusion CLI patients with high NLRs had significantly higher risks of 1-year all-cause and cardiac-related mortality and MALEs. The NLR can be used for prognostic prediction in these patients.

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Section: Plos Onecontrasting

confidence: 88%

Neutrophil-to-lymphocyte ratio associated with an increased risk of mortality in patients with critical limb ischemia

Liu

2021

PLoS ONE

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show abstract

“…We previously reported that elevated serum uric acid was associated with the prevalence of metabolic syndrome, left ventricular hypertrophy, left ventricular diastolic dysfunction in various study populations such as apparently healthy individuals, patients with cardiometabolic abnormalities, and patients with ST-segment elevation myocardial infarction [28][29][30][31] . However, we did not nd a signi cant association between hyperuricemia and MACE and MALE in the present study.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-lymphocyte Ratio Associated With an Increased Risk of Mortality in Patients With Critical Limb Ischemia

2021

Preprint

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Purpose: Association of the neutrophil-to-lymphocyte ratio (NLR) with mortality has not been comprehensively explored in critical limb ischemia (CLI) patients. We investigated the association between the NLR and clinical outcomes in CLI.Materials and methods: We retrospectively enrolled consecutive CLI patients during 1/1/2013–12/31/2018. Receiver operating characteristic curve analysis determined NLR cutoffs for 1-year in-hospital, all-cause and cardiac-related mortality, and major adverse cardiovascular events (MACEs) and limb events (MALEs).Results: Among 195 patients (age, 74.0 years, SD: 11.5; 51.8% male; BMI, 23.4 kg/m2, SD: 4.2), 14.4% exhibited acute limb ischemia. After 1 year, patients with an NLR>8 had higher in-hospital mortality (21.1% vs. 3.6%, P<0.001), all-cause mortality (54.4% vs. 13.8%, P<0.001), cardiac-related mortality (28.1% vs. 6.5%, P<0.001), MACE (29.8% vs. 13.0%, P=0.008), and MALE (28.1% vs. 13.0%, P=0.021) rates than those with an NLR<8. In multivariate logistic regression, an NLR≥8 was significantly associated with all-cause (P<0.001) and cardiac-related (adjusted HR: 5.286, 95% CI: 2.075-13.47, P<0.001) mortality, and an NLR≥6 was significantly associated with MALEs (adjusted HR: 2.804, 95% CI: 1.292-6.088, P=0.009).Conclusion: CLI patients with high NLRs had higher risks of 1-year all-cause and cardiac-related mortality and MALEs. The NLR can be used for prognostic prediction in these patients.

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Serum uric acid was an independent predictor of mortality in ST-segment elevation myocardial infarction patients with Killip I other than Killip II-IV Comment on "J Cardiovasc Thorac Res 2016;8:56-60"

Cited by 2 publications

References 5 publications

Neutrophil-to-lymphocyte ratio associated with an increased risk of mortality in patients with critical limb ischemia

Neutrophil-to-lymphocyte ratio associated with an increased risk of mortality in patients with critical limb ischemia

Neutrophil-to-lymphocyte Ratio Associated With an Increased Risk of Mortality in Patients With Critical Limb Ischemia

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