Serum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study

Abstract

Objective To analyze the association between serum uric acid (SUA) and metabolic state in obese inpatients and preliminarily explore potential mechanisms of hyperuricemia in obesity. Methods A total of 153 obese inpatients were selected and assigned based on SUA level to the normal uric acid (NC group) or high uric acid (HUA) group. Patients’ sex, age, height, weight, blood pressure, BMI, and prevalence of metabolic syndrome were collected and recorded. SUA, FPG, FIns, HOMA-IR, HOMA-IS, HbA 1c , TGs, TC, LDL-C, and HDL-C levels were tested. Pearson correlation analysis was performed to analyze the correlation between SUA and related metabolic indicators. Logistic regression was performed to analyze independent risk factors of hyperuricemia in obesity. Results In the HUA group, the patients were predominantly males, and BMI, DBP, TGs, FPG, FIns, HOMA-IR, HOMA-IS, and metabolic syndrome were higher than those in the NC group ( P <0.05), while HDL-C was lower than that in the NC group ( P <0.05). There were no significant differences between the groups in TC or LDL-C. Pearson correlation analysis showed that in obese patients, SUA was positively correlated with BMI, FIns, HOMA-IR, HOMA-IS, TGs, andmetabolic syndrome and negatively correlated with age and HDL-C. Logistic regression showed that BMI, hyperinsulinemia, and insulin resistance were independent risk factors of hyperuricemia. Conclusion Development of hyperuricemia in obese populations might be correlated with hyperinsulinemia or insulin resistance.

Adipose Tissue Insulin Resistance Is Positively Associated With Serum Uric Acid Levels and Hyperuricemia in Northern Chinese Adults

“…IR has been suggested to be the mediator between obesity and hyperuricemia (33). The amelioration of IR decreased the serum UA level independent of weight loss, while the UA-lowering therapy did not change insulin sensitivity in hyperuricemia subjects (34,35).…”

Decreased level of soluble receptor activator of nuclear factor-κβ ligand (sRANKL) in overweight and obese children

“…New findings from the present study are the detection of the inverse relationship between UA and sRANKL, after adjustment of lipids and insulin resistance variables. In the literature, the association between elevated serum UA with obesity, insulin resistance, glucose and lipids disturbances, metabolic syndrome, hypertension, carotid atherosclerosis, and an increased incidence of CV events in young adults, is well documented (2,(50)(51)(52)(53)(54). Excess of UA has paradoxically pro-oxidant effects in the vascular cells, impaired nitric oxide production, increased cytokines (IL 1b, IL 6, TNF a, CRP, MCP-1), and platelet-derived growth factors expression, leading to endothelial dysfunction and VSMC proliferation (55)(56)(57).…”

Evaluation of uric acid disorders and associated factors in essential hypertensive patients at Wolkite University specialized hospital, Southern Ethiopia

“…Those patients with insulin resistance secrete larger amounts of insulin to maintain an adequate glucose metabolism in negative feedback mechanism and the kidney responds to the high insulin levels by decreasing uric acid clearance, probably linked to insulin-induced urinary sodium retention in centrally obese patients. Meanwhile, hyperuricemia in turn can induce obesity by enhancing liver and peripheral fat production [22,27,31]. Although, the necessary opportunities were made to decrease the possible limitations of this study, the interpretation of result should be in light of the following limitations.…”

“…In hypertensive patients, monosodium urate crystals are deposited and easily precipitated on the vascular wall of blood vessels, due to mechanical stimuli caused by blood pressure that affect blood coagulation, which likely leads to arteriosclerosis and other related cardiovascular complications of hypertension with poor prognosis [21,22].…”