Serum uric acid level as a marker of cardiovascular disease in diabetic individuals

Abstract

Background: Serum Uric acid (SUA) had always been thought of as a metabolically inert end product of purine metabolism without physiological significance except gouty diathesis. However, it has been recently associated with insulin resistance and also considered as a risk marker for the development of diseases like diabetes, coronary heart disease.
 Aims and Objective: In this study we aim to determine the incidence of hyperuricemia in diabetic individuals and also study the relation of SUA with the other established risk factor of cardiovascular diseases, as it is one of the long term complications of Diabetes.
 Materials and Methods: The study enrolled 120 subjects. Group I (test group) comprised of 60 known cases of type II DM on oral anti-diabetic drugs. The control group comprised of 60 subjects who were non diabetic and not suffering from any major illness. The protocol of the study was approved by ethical committee of the institute. Total cholesterol, HDL, TG, glucose, SUA was estimated while parameters like LDL and VLDL were calculated.
 Results: A highly significant increased SUA, total cholesterol, HDL, TG, glucose, LDL and VLDL was seen in type II DM (p<0.0001) when compared with control while a significant (p<0.05) positive correlation was observed between SUA and total cholesterol and TG. In study group a negative correlation though not statistically significant was observed between SUA and fasting blood sugar level.
 Conclusion: SUA is definitely associated with development of complications of diabetes in the form of cardiovascular disease. This may be due to its influence on the deranged lipid metabolism and hyperglycemia.

Evaluation of Serum Uric Acid, Glucose and Other Glycemic Parameter in Type Ii Diabetic Individuals

“…So, this negative correlation of SUA and FBG indicates uric acid as a potential biomarker to find deterioration in glucose metabolism. 40 In our study from table 3, SUA, FBG and PPBG level in case at different level of HbA1c shows very interesting finding; when mean HbA1c (7.07%) level there is a rise in mean SUA and FBG levels. A further rise in HbA1c(8.8%) result to further increase in mean uric acid and FBG level but when mean HbA1c (>10%) there is decrease in mean uric acid but increase in FBG level is observed.…”