Serum Uric Acid Is a Determinant of Metabolic Syndrome in a Population-Based Study

Onat, Altan; Uyarel, Hüseyin; Hergenç, Gülay; Karabulut, Ahmet; Albayrak, Sinan; Sarı, İbrahim; Yazıcı, Mehmet; Keleş, İbrahim

doi:10.1016/j.amjhyper.2006.02.014

Cited by 220 publications

(148 citation statements)

References 27 publications

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“…19 However, our study did not find significant interactions between uric acid status and BMI after stratified analysis. A previous study has found the strongest association between uric acid and SBP in the lowest quintiles of fasting glucose, 21 although we did not observe an interaction between fasting glucose and uric acid in our study. A prospective investigation of SUA and the risk of diabetes suggested a positive association between the plasma concentration of uric acid and the incidence of type 2 diabetes in Chinese individuals.…”

Section: Discussioncontrasting

confidence: 93%

Interaction between serum uric acid and triglycerides in relation to blood pressure

et al. 2010

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The aim of this study was to examine the independent relationship between serum uric acid (SUA) and blood pressure, and to assess their joint effects on obesity, fasting glucose and lipids. The study samples were from a community-based health examination survey in Xuzhou, Jiangsu province of China (2009). Blood pressure, body mass index, fasting glucose, lipids and SUA were measured. After excluding individuals with fasting glucose greater than 7 mmol l À1 , a total of 8415 subjects with biomarkers available were included in the present study. Blood pressure increased with elevated SUA levels, after adjusting for age and sex. Further adjustment for fasting glucose, lipids and alcohol consumption did not change the increasing trend. The associations between uric acid and hypertension were most evident in those with highest quintiles of high-density lipoprotein cholesterol (HDL-C). In addition, the associations were significant in both men and women, and we found significant interactions between uric acid status and age on hypertension. When the joint effects were examined, we found an additive effect of triglycerides and uric acid levels on diastolic blood pressure (DBP). There was significant association between SUA and hypertension, independent of other metabolic risk factors. HDL-C levels may modify the associations between uric acid and hypertension. The effects of triglycerides and uric acid levels on DBP were additive.

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Section: Discussioncontrasting

confidence: 93%

Interaction between serum uric acid and triglycerides in relation to blood pressure

et al. 2010

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“…In general, our data agree with several cross-sectional studies from different populations that established an association between SUA and MS 2,26 , and with a Brazilian study that included 352 white male individuals from high social class 27 and an observational study that evaluated 756 individuals (369 men) from a convenience sample 12 .…”

Section: Discussionsupporting

confidence: 79%

“…The association between serum uric acid (SUA) and cardiovascular (CV) diseases such as hypertension 1 , metabolic syndrome (MS) 2 , coronary and cerebral vascular diseases 3,4 has been reported in several epidemiologic studies. However, SUA has not been considered an independent cardiovascular risk factor, but only an additional factor associated with CV diseases due to the presence of other conditions such as obesity, dyslipidemia, hypertension, use of diuretics or insulin resistance 5 .…”

Section: Introductionmentioning

confidence: 99%

Distribuição por gênero de ácido úrico sérico e fatores de risco cardiovascular: estudo populacional

Rodrigues¹,

Baldo²,

Capingana³

et al. 2012

Arq. Bras. Cardiol.

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“…For example, the ORs for metabolic syndrome increase with the gender-specific quartiles of uric acid levels after adjusting for age, total cholesterol and smoking status in Japanese adults. 29 In a population-based study, Onat et al 30 have shown that the OR of metabolic syndrome is 1.89 using the top-versus-bottom tertile of uric acid level adjusting for possible confounders. In addition, uric acid is independently correlated with number of metabolic syndrome components.…”

Section: Discussionmentioning

confidence: 99%

Obesity and hepatitis B infection are associated with increased risk of metabolic syndrome in university freshmen

Chiu

et al. 2007

Int J Obes

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Objective: To investigate the prevalence of metabolic syndrome and its associated risk factors in a cohort of university freshmen. Design: A cross-sectional study in a university health center in North Taiwan. Subjects: A total of 8226 students (mean age: 19.272.3 years) receiving pre-entrance health examinations and lifestyle questionnaires during the 2005-2006 academic year were recruited. Measurements: A fasting plasma glucose, lipids, uric acid and hepatitis B serology were measured for each subject. The prevalence of metabolic syndrome and its individual components were examined using the America Heart Association and National Heart Lung Blood Institute criteria. The risk factors for metabolic syndrome were identified using a multivariate logistic regression analysis. Results: The prevalence of overweight, obesity and metabolic syndrome was 12.7% (17.0% in men and 7.6% in women), 13.0% (18.4% in men and 6.4% in women) and 4.6% (6.4% in men and 2.4% in women). The risk for metabolic syndrome increased with an increase of body mass index and plasma uric acid level, and decreased with the vigorous physical activity and current alcohol drinking. Furthermore, as compared to subjects with seroprotective titers from hepatitis B vaccination (antiHBs( þ ) and anti-HBc(À)), those without protective titers of anti-HBs after vaccination or without hepatitis B infection (antiHBs(À) and anti-HBc(À)) had 34% higher risk for metabolic syndrome, and those with natural infection of hepatitis B (anti-HBc( þ )) had 58% higher risk for metabolic syndrome. Conclusions: Overweight, obesity and metabolic syndrome were more common among men than women in university freshmen. Hepatitis B vaccination with anti-HBs( þ ) was associated with a lower risk of metabolic syndrome as compared to antiHBs(À). However, hepatitis B infection presented with anti-HBc( þ ) was associated with a higher risk of metabolic syndrome. The interplay between hepatitis B infection, hepatitis B vaccination and metabolic syndrome needs further investigation.

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Serum Uric Acid Is a Determinant of Metabolic Syndrome in a Population-Based Study

Cited by 220 publications

References 27 publications

Interaction between serum uric acid and triglycerides in relation to blood pressure

Interaction between serum uric acid and triglycerides in relation to blood pressure

Distribuição por gênero de ácido úrico sérico e fatores de risco cardiovascular: estudo populacional

Obesity and hepatitis B infection are associated with increased risk of metabolic syndrome in university freshmen

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