Serum uric acid concentration is not associated with handgrip strength, lean body mass or survival in gastrointestinal cancer patients

Trindade, Daniella B.; Araújo, Vanessa A.; Franco, Emanoelly P.; Fernandes, Renata C.; Carvalho, Ana Paula Perillo Ferreira; Pimentel, Gustavo D.

doi:10.1016/j.clnesp.2020.03.017

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…In vivo, it may offer a neuroprotective advantage in the neurodegenerative Alzheimer's disease [18], schizophrenia [19], Parkinson's disease [20], multiple sclerosis [21], and serves as a depression biomarker [22]. SUA concentrations are linked to muscle strength and lean mass [23], although this was not shown in gastrointestinal tract cancer patients [24]. SUA may serve as a risk factor to predict poor thyroid function [25] or an indicator of malnutrition [15].…”

Section: Uric Acid and Goutmentioning

confidence: 99%

“…Allopurinol, a ULT medicine, has not shown any efficacy in the prevention of a first gout flare in patients with asymptomatic hyperuricemia [84]. Fundamentally, SUA level is associated with physical capacity and muscle strength in healthy subjects [23,24] and may only be a biological marker of non-gout conditions such as cardiovascular damage but is not a risk factor for its development [51]. Controversially, pseudogout, which is caused by calcium pyrophosphate deposition (CPPD), could have the same inflammatory symptoms as gout without hyperuricemia [85].…”

Section: The Causes Of Hyperuricemia Irrelevant To Goutmentioning

confidence: 99%

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Why Does Hyperuricemia Not Necessarily Induce Gout?

Zhang

2021

Biomolecules

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Hyperuricemia is a risk factor for gout. It has been well observed that a large proportion of individuals with hyperuricemia have never had a gout flare(s), while some patients with gout can have a normuricemia. This raises a puzzle of the real role of serum uric acid (SUA) in the occurrence of gout flares. As the molecule of uric acid has its dual effects in vivo with antioxidant properties as well as being an inflammatory promoter, it has been placed in a delicate position in balancing metabolisms. Gout seems to be a multifactorial metabolic disease and its pathogenesis should not rely solely on hyperuricemia or monosodium urate (MSU) crystals. This critical review aims to unfold the mechanisms of the SUA role participating in gout development. It also discusses some key elements which are prerequisites for the formation of gout in association with the current therapeutic regime. The compilation should be helpful in precisely fighting for a cure of gout clinically and pharmaceutically.

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Section: Uric Acid and Goutmentioning

confidence: 99%

Section: The Causes Of Hyperuricemia Irrelevant To Goutmentioning

confidence: 99%

Why Does Hyperuricemia Not Necessarily Induce Gout?

Zhang

2021

Biomolecules

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show abstract

Section: Uric Acid and Goutmentioning

confidence: 99%

“…Allopurinol, a ULT medicine, has not shown any efficacy in the prevention of a first gout attack in patients with asymptomatic hyperuricemia [84]. Fundamentally, SUA level is associated with physical capacity and muscle strength in healthy subjects [23,24] and may only be a biological marker of non-gout conditions such as cardiovascular damage but is not a risk factor for its development [51]. Controversially, the pseudo-gout, which is caused by calcium pyrophosphate deposition (CPPD) deposition, could have the same inflammatory symptoms as gout without hyperuricemia [85].…”

Section: The Causes Of Hyperuricemia Irrelevant To Goutmentioning

confidence: 99%

Why Hyperuricemia Does Not Necessarily Induce Gout?

Zhang¹

2020

Preprint

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Hyperuricemia is a risk factor for gout. It has been well observed that a large proportion of hyperuricemia individuals have never had a gout attack(s), while some patients with gout can have a normuricemia. This raises a puzzle of the real role of serum uric acid (SUA) in the occurrence of gout attacks. As the molecule of uric acid has its dual effects in vivo with antioxidant property as well as being an inflammatory promoter, it has been placed in a delicate position in balancing metabolisms. Gout seems to be a multifactorial metabolic disease and its pathogenesis should not rely solely on hyperuricemia or MSU crystal. This critical review aims to unfold the mechanisms of the SUA role participating in gout development. It also discusses some key elements which are prerequisite for the formation of gout in association with the current therapeutic regime. The compilation should be helpful in precisely fighting for a cure of gout clinically and pharmaceutically.

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“…In addition, serum uric acid is another important indicator to evaluate the prognosis of cancer. Related studies have confirmed that elevated serum uric acid levels are associated with the incidence and mortality risk of various diseases such as gastric cancer, colon cancer, renal cell carcinoma, and liver cancer [ 5 ]. Clinical studies have confirmed that hyperuricemia not only causes gout but also is closely related to kidney disease, cardiovascular disease, and endocrine and metabolic diseases.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Serum Oxidative Stress Level and Serum Uric Acid and Prognosis in Patients with Hepatitis B-Related Liver Cancer before Operation

Zhang

Tang

et al. 2022

Journal of Healthcare Engineering

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Aiming to explore the correlation between preoperative serum oxidative stress level and serum uric acid and prognosis of hepatitis B-related liver cancer, the clinical data of 712 patients with hepatitis B-related liver cancer from January 2019 to December 2020 were retrospectively analyzed. By using the receiver operating curve, the optimal critical values of preoperative superoxide dismutase (SOD), malondialdehyde (MDA), and serum uric acid (SUA) are determined. The single-factor and multifactor Cox models are applied to screen out the suspicious factors affecting the prognosis of patients with hepatitis B-related liver cancer. According to the survival status of patients, the optimal thresholds of SOD, MDA, and SUA before operation were 58.055/mL, 10.825 nmol/L, and 312.77 nmol/L, respectively. The results of univariate analysis show that the prognosis of patients is significantly correlated with preoperative SOD, MDA, and SUA levels and TNM staging P < 0.05 . Additionally, multivariate analysis demonstrates that preoperative SOD < 58.055 U/mL and SUA ≥ 312.770 mmol/L and TNM stage III-IV are independent risk factors for postoperative prognosis P < 0.05 . Our study suggests that SOD, SUA, and TNM staging have certain value in judging the early prognosis of patients with hepatitis B-related liver cancer. Patients with high preoperative SOD level and low preoperative SUA level can obtain better prognosis.

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Serum uric acid concentration is not associated with handgrip strength, lean body mass or survival in gastrointestinal cancer patients

Cited by 5 publications

References 31 publications

Why Does Hyperuricemia Not Necessarily Induce Gout?

Why Does Hyperuricemia Not Necessarily Induce Gout?

Why Hyperuricemia Does Not Necessarily Induce Gout?

Correlation between Serum Oxidative Stress Level and Serum Uric Acid and Prognosis in Patients with Hepatitis B-Related Liver Cancer before Operation

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