Serum Transfusion in Hemophiliacs

Abstract

-136-To study the effectiveness of serum transfusion in hemophiliacs, in vitro experiments and in vivo trials were carried out. In in vitro experiments, addition of one volume of serum shortened consisently the kaolin added partial thromboplastin time (kaolin PTT) of both hemophilia A and B plasmas. In the former, the shortening was the same as in the control plasma , but the elevation of AHG level was not seen in the mixture, while in the latter the shortening was more marked than in the control plasma and the PTC level was elevated. In in vivo studies, 80 ml of serum was transfused in each of the cases of hemophilia A and B. In the former, kaolin PTT was shortened from 119.0 to 92.0 sec., whereas the level of AHG was not changed. In the latter, kaolin PTT was shortened from 262.0 to 151.0 sec, and the PTC level was elevated from less than 1% normal to 2.8% normal. Serum transfusion is thought to be an effective hemostatic procedure in hemophilia A and especially in hemophilia B.hemophilia A and B.

Inhibition of the lytic phase of murine T-cell-mediated alloimmune cytotoxicity by a rat antiactivated T-cell antiserum

“…The capacity of the anti-ATC to inhibit CTL from several mouse strains further distinguishes this antiserum from other xenogeneic and allogeneic antilymphocyte sera which were recently reported to block CTL activity (in the absence of complement) in a strain-specific fashion (34)(35)(36)(37). The antisera investigated in those studies were proposed, by virtue of their reactivity with Lyt-2, Lyt-3, or idiotypic determinants, to block lytic activity by binding to CTL antigen recognition structures.…”