Serum Total Sialic Acid and Enzymes Levels in Patients with Asthma, Abdominal Bacterial Infectionsand Bone Disorders

Abstract

This study was designed to evaluate the clinical application of serum total sialic acid (TSA), total serum protein (TSP) and enzyme activity of alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) in serum of 70 subjects. The study involved four groups, the first group (G1) consisted of 17 normal healthy individuals , group 2 (G 2) consisted of 20 patients with asthma, group 3 of 15 patients with abdominal bacterial infection , group 4 involved 18 patients with bone disorders. They were obtained from clinical routine work of different hospitals of Baghdad, Al-Wasity hospital and laboratory center for allergy of asthma. The levels of TSA, TSP and the activity of ALP and GGT were significantly increased in sera of patients with asthma and abdominal bacterial infection (P< 0.001) as compared with healthy control group. There was a significant changes observed in TSA, TSP, ALP and GGT in patients with bone diseases. A significant positive correlation between TSA and ALP was observed in patients with asthma and a negative correlation with some cases of bone diseases. A positive correlation between TSA and GGT in patients with asthma and abdominal infection and some cases of bone disease. In conclusion serum sialic acid levels might prove to be sensitive but not necessary specific marker of diagnosis of asthma, abdominal infection and some cases of bone disease.