Serum testosterone level and related metabolic factors in men over 70 years old

Tang, Yih-Jing; Lee, W. J.; Chen, Y. T.; Liu, P. H.; Lee, M. C.; Sheu, Wayne H‐H

doi:10.1007/bf03346327

Cited by 26 publications

(22 citation statements)

References 38 publications

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“…In our sample, FAI and total testosterone did not correlate with BMI, either in the whole sample or after splitting by group. We found a correlation between waist to hip ratio only in control subjects and total testosterone (not FAI) which is reported in the literature (20). Psychotic subjects did not show this correlation, supporting the view that they present a different metabolic pattern.…”

Section: Discussionsupporting

confidence: 83%

Testosterone in Newly Diagnosed, Antipsychotic-Naive Men With Nonaffective Psychosis

Fernández-Egea

García-Rizo

Miller

et al. 2011

Psychosomatic Medicine

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Objective Schizophrenia has been associated with age-related abnormalities, including abnormal glucose tolerance, increased pulse pressure, increased inflammation, abnormal stem cell signalling and shorter telomere length. These metabolic abnormalities as well as other findings suggest schizophrenia and related disorders might be associated with accelerated aging. Testosterone activity has a progressive decline with increasing age. Methods We tested the hypothesis that circulating biologically active testosterone is lower in newly diagnosed, antipsychotic-naïve male patients with nonaffective psychosis than in matched control subjects. Results Patients (n=33) were matched to control subjects (n=33) for age, gender, body mass index, socioeconomic status of the family of origin, and smoking. The free androgen index (FAI), a measure of biologically active testosterone, was significantly lower in the psychosis group [mean 57.7%, SD=26.1] than in control subjects [71.6%, 27.0; p=0.04], with an effect size of 0.53. Multivariate analysis also supported the findings. In the psychosis group, FAI had a significant negative correlation with the conceptual disorganization item (r=-0.35, p=0.049), but not with reality distortion (r=-0.21; p=0.24), negative symptoms (r=0.004; p=0.98) or depression (r=-0.014; p=0.94). Conclusion Lower testosterone is consistent with accelerated aging in nonaffective psychosis, but further testing of this hypothesis is needed.

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Section: Discussionsupporting

confidence: 83%

Testosterone in Newly Diagnosed, Antipsychotic-Naive Men With Nonaffective Psychosis

Fernández-Egea

García-Rizo

Miller

et al. 2011

Psychosomatic Medicine

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“…Most prior cross-sectional studies have observed inverse associations between androgen concentrations and inflammatory biomarkers (Laaksonen et al 2003; Bhatia et al 2006; Tang et al 2007; Schneider et al 2009; Kaplan et al 2010; Kupelian et al 2010; Brand et al 2012; Zhang et al 2012). A recent study in Chinese men showed that lower concentrations of total and calculated free testosterone were associated with higher CRP concentration (Zhang et al 2012).…”

Section: Discussionmentioning

confidence: 98%

“…Two randomized controlled trials of androgen replacement therapy in hypogonadal men reported a decrease in the concentration of pro-inflammatory cytokines in the active therapy arm (Malkin et al 2004; Kalinchenko et al 2010), but other trials did not confirm these findings (Ng et al 2002; Singh et al 2002; Kapoor et al 2007; Nakhai-Pour et al 2007). A few epidemiologic studies have evaluated the cross-sectional association between sex steroid hormones and inflammatory biomarkers in men, but had inconsistent results (Laaksonen et al 2003; Van Pottelbergh et al 2003; Bhatia et al 2006; Maggio et al 2006; Nakhai Pour et al 2007; Tang et al 2007; Maggio et al 2009; Schneider et al 2009; Kaplan et al 2010; Kupelian et al 2010; Brand et al 2012; Zhang et al 2012). Moreover, some of the latter studies did not adjust for important confounders (e.g., smoking and obesity) (Laaksonen et al 2003; Van Pottelbergh et al 2003; Bhatia et al 2006; Tang et al 2007; Kaplan et al 2010), and very few studies mutually adjusted for other sex hormones (Nakhai Pour et al 2007; Zhang et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…A few epidemiologic studies have evaluated the cross-sectional association between sex steroid hormones and inflammatory biomarkers in men, but had inconsistent results (Laaksonen et al 2003; Van Pottelbergh et al 2003; Bhatia et al 2006; Maggio et al 2006; Nakhai Pour et al 2007; Tang et al 2007; Maggio et al 2009; Schneider et al 2009; Kaplan et al 2010; Kupelian et al 2010; Brand et al 2012; Zhang et al 2012). Moreover, some of the latter studies did not adjust for important confounders (e.g., smoking and obesity) (Laaksonen et al 2003; Van Pottelbergh et al 2003; Bhatia et al 2006; Tang et al 2007; Kaplan et al 2010), and very few studies mutually adjusted for other sex hormones (Nakhai Pour et al 2007; Zhang et al 2012). Therefore, the aim of this study was to investigate the cross-sectional association between endogenous sex steroid hormones (total testosterone, calculated free testosterone, total estradiol, calculated free estradiol and androstanediol glucuronide, a metabolite of dihydrotestosterone), sex hormone binding protein (SHBG) and biomarkers of inflammation (CRP and white blood cell count [WBC]) in a large nationally representative sample of US men after carefully adjusting for all important confounders.…”

Section: Introductionmentioning

confidence: 99%

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Association between endogenous sex steroid hormones and inflammatory biomarkers in US men

et al. 2013

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Sex steroid hormones and inflammatory biomarkers are both associated with the development and progression of chronic diseases, but their interrelationship is relatively uncharacterized. We examined the association of sex hormones and sex hormone binding globulin (SHBG) with biomarkers of inflammation, C-reactive protein (CRP) and white blood cell (WBC) count. The study included data from 809 adult men in the National Health and Nutrition Examination Survey 1999–2004. Geometric means and 95% confidence intervals were estimated separately for CRP and WBC concentrations by sex steroid hormones and SHBG using weighted linear regression models. Higher concentrations of total (slope per 1 quintile in concentration, −0.18; P-trend, 0.001) and calculated free (slope, −0.13; P-trend, 0.03) testosterone were statistically significantly associated with lower concentrations of CRP, but not with WBC count. Men in the bottom quintile of total testosterone (≤3.3 ng/mL), who might be considered to have clinically low testosterone, were more likely to have elevated CRP (≥ 3 mg/L) compared to men in the top four quintiles (OR, 1.61; 95% CI, 1.00 – 2.61). Total and calculated free estradiol (E2) were positively associated with both CRP (Total E2: slope, 0.14; P-trend, <0.001; Free E2: slope, 0.15; P-trend, <0.001) and WBC (Total E2: slope, 0.02; P-trend, 0.08; Free E2: slope, 0.02; P-trend, 0.02) concentrations. SHBG concentrations were inversely associated with WBC count (slope, −0.03; P-trend, 0.04), but not with CRP. These cross-sectional findings are consistent with the hypothesis that higher androgen and lower estrogen concentrations may have an anti-inflammatory effect in men.

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“…The available evidence from these RCTs generally shows little effect of testosterone therapy on CRP (Aversa et al, 2010;Frederiksen et al, 2013;Kapoor et al, 2007;Nakhai-Pour et al, 2007;Ng et al, 2002), white blood cell count (Kalinchenko et al, 2010) or fibrinogen (Smith et al, 2005), although one RCT reported testosterone decreased CRP (Kalinchenko et al, 2010) among a subset of men. Larger observational studies among men usually, but not always, report serum testosterone inversely associated with CRP (Gannage-Yared et al, 2011;Haring et al, 2012;Kupelian et al, 2010;Laaksonen et al, 2003;Nakhai Pour et al, 2007;Zhang et al, 2013), white blood cell counts and/or its differentials (Brand et al, 2012;Haring et al, 2012;Tang et al, 2007) and fibrinogen (Bonithon-Kopp et al, 1988;Haring et al, 2012;Yang et al, 1993). Experimental and observational evidence may differ for a number of reasons: the small size of most RCTs of testosterone therapy, differences in the action of exogenous and endogenous testosterone, serum testosterone acting as a marker of health status or serum testosterone not capturing all androgen activity (Labrie et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Androgen activity and markers of inflammation among men in NHANES III

Schooling

2013

American J Hum Biol

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Objectives: Inflammation contributes to chronic diseases. Lower serum testosterone among men is associated with less inflammation, yet immune defense is thought to trade-off against reproduction with androgens adversely affecting immune function. Anti-androgens are effective at castrate levels of serum testosterone, suggesting serum testosterone may not capture all androgen activity. The association of two androgen biomarkers with key markers of inflammation was examined. Methods: The adjusted association of serum testosterone and androstanediol glucuronide with C-reactive protein, white blood cell, granulocyte and lymphocyte count, fibrinogen and hemoglobin, as a control outcome because testosterone administration raises hemoglobin, were examined in a nationally representative sample of 1490 US men from NHANES III phase 1 (1988-91) using multivariable linear regression. Results: Serum testosterone and androstanediol glucuronide were weakly correlated (0.13). Serum testosterone was associated with lower white blood cell count (−0.26*10−9 per standard deviation, 95% confidence interval (CI) −0.37 to −0.14) and granulocyte count (−0.21*10−9, 95% CI −0.29 to −0.13) but not with hemoglobin (0.02 g/L, 95% CI −0.89 to 0.92), adjusted for age, education, race/ethnicity, smoking and alcohol. Similarly adjusted, androstanediol glucuronide was not associated with white blood cell count (0.10*10−9, 95% CI −0.05 to −0.25), granulocyte count (0.12*10−9, 95% CI −0.02 to 0.25) or fibrinogen (0.05g/L, 95% CI −0.004 to 0.11), but was with hemoglobin (0.70g/L, 95% CI 0.07 to 1.32). Conclusions: Different androgen biomarkers had different associations with inflammatory markers, highlighting the need to consider several androgen biomarkers. The possibility remains that androgens may generate inflammatory processes with implications for chronic diseases.

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Serum testosterone level and related metabolic factors in men over 70 years old

Abstract: Total testosterone level is significantly related to metabolic and inflammatory factors in elderly men. Low total testosterone may be a significant indicator for development of metabolic syndrome in elderly men.

Cited by 26 publications

References 38 publications

Testosterone in Newly Diagnosed, Antipsychotic-Naive Men With Nonaffective Psychosis

Testosterone in Newly Diagnosed, Antipsychotic-Naive Men With Nonaffective Psychosis

Association between endogenous sex steroid hormones and inflammatory biomarkers in US men

Androgen activity and markers of inflammation among men in NHANES III

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