Serum testosterone and non‐alcoholic fatty liver disease in men and women in the <scp>US</scp>

Yim, Jeong Yoon; Kim, Jin Ju; Kim, Dong‐Hee; Ahmed, Aijaz

doi:10.1111/liv.13735

Cited by 63 publications

(55 citation statements)

References 37 publications

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“…3,19 The NHANES database included a detailed questionnaire which covered demographic and lifestyle information including depression and physical activity, anthropometric measures, and a comprehensive laboratory examination. 3,19 The NHANES database included a detailed questionnaire which covered demographic and lifestyle information including depression and physical activity, anthropometric measures, and a comprehensive laboratory examination.…”

Section: Clinical and Laboratory Evaluationsmentioning

confidence: 99%

“…Methods used for clinical and laboratory evaluations have been described in detail elsewhere. 3,19 The NHANES database included a detailed questionnaire which covered demographic and lifestyle information including depression and physical activity, anthropometric measures, and a comprehensive laboratory examination. Race/ ethnicity was categorised as non-Hispanic white, Hispanic (Mexican American, Other Hispanic), non-Hispanic black, or Asians/other.…”

Section: Clinical and Laboratory Evaluationsmentioning

confidence: 99%

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Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Kim

Yoo

et al. 2019

Aliment Pharmacol Ther

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Background: Currently, the relationship between depression and non-alcoholic fatty liver disease (NAFLD) is not clearly defined. Aim:To determine whether depression is associated with NAFLD and NAFLD-related advanced fibrosis in a large population sample. Methods: We performed a cross-sectional analysis using the 2007-2016 National Health and Nutrition Examination Survey database among adults (20 years or older) in the United States (US). Depression and functional impairment due to depression were assessed with the Patient Health Questionnaire (PHQ-9). NAFLD was defined by utilising the US fatty liver index (USFLI), hepatic steatosis index (HSI) and the fatty liver index (FLI) in the absence of other causes of chronic liver disease. The presence and absence of advanced fibrosis in NAFLD were defined by Fibrosis-4 score.Results: Of the 10 484 subjects (mean age 47.0 years; 48.8% men), the prevalence of depression and functional impairment due to depression was higher in subjects with NAFLD than in those without. Compared to subjects without depression, those with depression were 1.6-2.2-fold more likely to have NAFLD. In our multivariate analyses, depression_med was associated with increased risk of NAFLD using USFLI (odds ratio [OR] 1.48 95% confidence interval [CI] 1.17-1.87), HSI (OR 1.51 95% CI 1.04-2.19) and FLI (OR 2.01 95% CI 1.65-2.48), respectively. The addition of diabetes, obesity and lipid profile to the model reduced the ORs for depression, but the significance persisted. Depression was not associated with NAFLD-related advanced fibrosis. Conclusions:In a nationally representative sample of US adults, depression was independently associated with NAFLD. | 591KIM et al.

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Section: Clinical and Laboratory Evaluationsmentioning

confidence: 99%

Section: Clinical and Laboratory Evaluationsmentioning

confidence: 99%

Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Kim

Yoo

et al. 2019

Aliment Pharmacol Ther

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“…By contrast, the female component genes showed no significant enrichment after correction for multiple hypothesis testing (Benjamini-Hochberg corrected p > 0.1). In men, low serum testosterone levels are associated with cirrhosis and non-alcoholic fatty liver disease (NAFLD), with decreasing levels corresponding to increased disease severity(Sinclair et al 2015;Mody et al 2015;Yim et al 2018) . Previous studies also find this inverse relationship in post-menopausal women(Sinclair et al 2015;Mody et al 2015;Yim et al 2018) ; however,…”

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confidence: 99%

Sex-specific genetic effects across biomarkers

Flynn

Tanigawa

Rodríguez

et al. 2019

Preprint

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Sex differences have been shown in laboratory biomarkers; however, the extent to which this is due to genetics is unknown. In this study, we infer sex-specific genetic parameters (heritability and genetic correlation) across 33 quantitative biomarker traits in 181,064 females and 156,135 males from the UK Biobank study. We apply a Bayesian mixture model, Sex Effects Mixture Model, to Genome-wide Association Study summary statistics in order to (1) estimate the contributions of sex to the genetic variance of these biomarkers and (2) identify variants whose statistical association with these traits is sex-specific. We find that the genetics of most biomarker traits are shared between males and females, with the notable exception of testosterone, where we identify 119 female and 444 male-specific variants. These include protein-altering variants in steroid hormone production genes ( POR, CYP3A43, UGT2B7 ). Using the sex-specific variants as genetic instruments for Mendelian Randomization, we find evidence for causal links between testosterone levels and height, body mass index, waist circumference, and type 2 diabetes. We also show that sex-specific polygenic risk score models for testosterone outperform a combined model. Overall, these results demonstrate that while sex has a limited role in the genetics of most biomarker traits, sex plays an important role in testosterone genetics.

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“…Some studies have con rmed that dysregulated sexual hormone disorders are involved in the pathogenesis of NAFLD and sarcopenia. Testosterone, as a potent anabolic hormone, can promote muscle protein synthesis [24]. Sarcopenia, which is related to the reduction of physical activity, the lack of anabolic hormones, and the decrease of pro-in ammatory cytokines, has been associated with NAFLD independent of metabolic syndrome features [5,25].…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia Is Associated with the Presence of Nonalcoholic Fatty Liver Disease in Zhejiang Province, China: A Cross-Sectional Observational Study.

Wang

Zhu

Zhou

et al. 2020

Preprint

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Background Nowadays, both nonalcoholic fatty liver disease (NAFLD) and sarcopenia have attracted extensive attention in public health. However, the relationship between NAFLD and sarcopenia remains unclear. This study aimed to clarify the gender-specific association between sarcopenia and NAFLD according to the Asian Working Group for Sarcopenia (AWGS). Methods Dual-energy X-ray absorptiometry (DXA) and hepatic ultrasonography were measured in 578 participants (92 men and 486 women) during their annual health examinations. Multivariate logistic regression models were used to explore the association between NAFLD and sarcopenia with its two components. Results 150 participants (30 men and 124 women) had NAFLD. The prevalence of sarcopenia was higher among the participants with NAFLD than those without (men: 20.0% vs. 9.7%, P = 0.295, women: 15.3% vs. 8.0%, P = 0.019). Low muscle mass (LMM) was independently associated with NAFLD in both men and women (men: odds ratio [OR], 2.88; 95% confidence interval [CI] 1.52–5.46; women: OR, 2.08; 95%CI 1.63–2.67). Whereas, low muscle strength (LMS) was independently associated with NAFLD only in men participants, with the OR of 1.15 (95%CI 1.02–1.28). Conclusion The occurrence of sarcopenia was associated with a higher risk of NAFLD, especially in men, as demonstrated by lower muscle mass and lower muscle strength.

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Serum testosterone and non‐alcoholic fatty liver disease in men and women in the US

Abstract: In this nationally representative sample of adults in the US, low total testosterone levels were associated with suspected non-alcoholic fatty liver disease in men and post-menopausal women independent of known risk factors.

Cited by 63 publications

References 37 publications

Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Sex-specific genetic effects across biomarkers

Sarcopenia Is Associated with the Presence of Nonalcoholic Fatty Liver Disease in Zhejiang Province, China: A Cross-Sectional Observational Study.

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