Serum Soluble Interleukin 2 Receptor Levels in Erythrodermic Cutaneous T-Cell Lymphoma Correlate With Response to Photopheresis-Based Treatment

Extracorporeal photochemotherapy in patients with cutaneous T‐cell lymphoma: is clinical response predictable?

“…Other investigators have published that high serum levels of LD indicate an unfavourable response to ECP 13–15 . In our study we found only slightly elevated mean values of LD and, indeed, the responding group was the higher one.…”

“…The level of lactate dehydrogenase (LD) is also used clinically as a prognostic factor to characterize the growth and invasive potential of tumours 12 . Studies have indicated that high serum levels of sIL‐2R and LD correlate with a poor therapy response and prognosis 13–15 …”

Primary cutaneous T‐cell lymphoma, unspecified, exhibiting an aggressive clinical course and a cytotoxic phenotype

“…TCR β F1 + phenotype does not fit into γδ T-cell lymphoma neither. [5][6][7] In our case, sIL-2R increased when she developed nodular cutaneous lesions although it was normal during her initial visit. In most cases of this category, however, aberrant CD4 + T-cell phenotypes with loss of pan-T-cell antigens are seen.…”

Clinical Trials and Efficacy Assessment in the Therapy of Cutaneous T Cell Lymphoma

“…With a chronic disease like CTCL, surrogate markers are a necessity. Noncutaneous surrogate markers have been proposed, such as serum levels of soluble interleukin (IL)‐2 receptor3 and eosinophil count 4. However, each of these has to be grounded in its correlation with skin involvement, making the recording of the examination of the patient the crucial event in monitoring disease activity.…”