Serum Soluble Interleukin 2 Receptor Level as a Marker of Acute Rejection in Pediatric Kidney Transplant Recipients

Hagras, Amal; Salah, Doaa M.; Ahmed, Dalia; Elaal, Omnia K Abd; Elghobary, Hany; Fadel, Fatina

doi:10.1159/000486402

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Acute graft dysfunction (AGD) was defined as rise of serum creatinine > 25% of the baseline level [ 9 ]. Presumed acute rejection (PRAR) was defined as AGD which is clinically diagnosed as acute rejection (after exclusion of other causes of AGD such as infection and dehydration) and medically treated by pulse methylprednisolone therapy, but kidney biopsy was not performed or did not show evidence of rejection [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Monitoring of blood glucose after pediatric kidney transplantation: a longitudinal cohort study

Salah

Hafez

Selem³

et al. 2022

Pediatr Nephrol

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Background Glucose metabolism after kidney transplantation (KT) is highly dynamic with the first post-transplantation year being the most critical period for new-onset diabetes after transplantation (NODAT) occurrence. The present study aimed to analyze dynamics of glucose metabolism and report incidence/risk factors of abnormal glycemic state during the first year after KT in children. Methods Twenty-one consecutive freshly transplanted pediatric kidney transplant recipients (KTRs) were assessed for fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT) weekly for 4 weeks, then every 3 months for 1 year. Results Interpretation of OGTT test showed normal glucose tolerance (NGT) in 6 patients (28.6%) while 15 (71.4%) experienced impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) at any time point of monitoring. Seven patients had NODAT, for which three needed insulin therapy. Hyperglycemia onset was 7.8 ± 13.12 weeks (median (range) = 1 (0–24) week) after KT. Percent of patients with abnormal OGTT was significantly more than that of IFG (38.1% vs. 71.4%, p = 0.029). Patients with abnormal glycemic state had significantly elevated trough tacrolimus levels at 6 months (p = 0.03). Glucose readings did not correlate with steroid doses nor rejection episodes while positively correlating with tacrolimus doses at 3 months (p = 0.02, CC = 0.73) and 6 months (p = 0.01, CC = 0.63), and negatively correlating with simultaneous GFR at 9 months (p = 0.04, CC = − 0.57). Conclusions Up to two thirds of pediatric KTRs (71.4%) experienced abnormal glycemic state at some point with peak incidence within the first week up to 6 months after KT. OGTT was a better tool for monitoring of glucose metabolism than FPG. Abnormal glycemic state was induced by tacrolimus and adversely affected graft function. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information.

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Section: Methodsmentioning

confidence: 99%

Monitoring of blood glucose after pediatric kidney transplantation: a longitudinal cohort study

Salah

Hafez

Selem³

et al. 2022

Pediatr Nephrol

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“…In KTR group graft function was assessed by measurement of serum creatinine and proteinuria. Acute graft dysfunction (AGD) was defined as rise of serum creatinine > 25% of the baseline level [11]. Chronic rejection was defined clinically as a progressive deterioration of graft function with ≥ 15% irreversible rise in creatinine within 1 to 3 months and proteinuria ≥ 1 g/24 h together with a histologic diagnosis of interstitial fibrosis and tubular atrophy (IFTA) [12].…”

Section: Methodsmentioning

confidence: 99%

Covid-19 in Egyptian hemodialysis and kidney transplant children: retrospective analysis of single center experience

et al. 2022

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Background Chronic kidney disease stage 5 (CKD 5) populations have peculiar risk for severe Covid-19 infection. Moreover; pediatric data are sparse and lacking. The aim of this study is to report our experience in CKD 5 children treated by hemodialysis (CKD 5D) and CKD 5 children after kidney transplantation (KTR) during one year of Covid-19 pandemic. Methods Retrospective analysis of 57 CKD 5 children with Covid-19 like symptoms during 1 year pandemic was performed. A cohort of 19 confirmed patients (13 CKD 5D and 6 KTR) was analyzed in details as regard clinical, laboratory, radiological criteria, management and their short term outcome. Results Conclusion Pediatric patients on regular HD (CKD 5D) are at higher risk and worse outcome of Covid-19 infection than KT recipients (KTR). Pre-existing HTN and shorter duration after KT are potential risk factors. Reversible AGD after KT and CVC related infections in HD patients are additional presenting features of Covid-19 infection.

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Development, analytical validation, and initial clinical evaluation of a radioimmunoassay for the measurement of soluble CD25 concentrations in canine serum

Buono

Lidbury

Wood

et al. 2019

Veterinary Immunology and Immunopathology

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Serum Soluble Interleukin 2 Receptor Level as a Marker of Acute Rejection in Pediatric Kidney Transplant Recipients

Cited by 4 publications

References 12 publications

Monitoring of blood glucose after pediatric kidney transplantation: a longitudinal cohort study

Monitoring of blood glucose after pediatric kidney transplantation: a longitudinal cohort study

Covid-19 in Egyptian hemodialysis and kidney transplant children: retrospective analysis of single center experience

Development, analytical validation, and initial clinical evaluation of a radioimmunoassay for the measurement of soluble CD25 concentrations in canine serum

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