Serum selenium levels predict survival after breast cancer

Lubiński, Jan; Marciniak, Wojciech; Muszyńska, Magdalena; Huzarski, Tomasz; Gronwald, Jacek; Cybulski, Cezary; Jakubowska, Anna; Dębniak, Tadeusz; Falco, Michał; Kładny, Józef; Kotsopoulos, Joanne; Sun, Ping; Narod, Steven A.

doi:10.1007/s10549-017-4525-9

Cited by 43 publications

(49 citation statements)

References 20 publications

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“…Perhaps this difference is associated with other environmental factors, including diet, however it seems that MMF evidently decreases serum Se level in younger patients. Low serum selenium (≤ 70 μg/L) is associated with an increased risk of developing breast cancer [20]. Our results showed Se concentrations below 70 μg/L in younger patients using MMF, which is significant for both patients and clinicians, due to the increased risk of cancer development [20,21].…”

Section: Discussionmentioning

confidence: 61%

“…Serum selenium, iron, zinc, and copper levels were quantified by inductively coupled mass spectroscopy (ICP-MS NexION 350D, PerkinElmer) using methane to reduce polyatomic interferences, following Lubinski et al [20,21]. Calibration standards were prepared by diluting 10 mg/L Multi-Element Calibration Standard 3 (PerkinElmer Pure Plus, PerkinElmer Life and Analytical Sciences, USA) with a blank reagent consisting of a 0.65% solution of nitric acid (Merck, Germany) and 0.002% Tryton X-100 (PerkinElmer, USA).…”

Section: Element Assaymentioning

confidence: 99%

“…Another bioelement, selenium (Se), also affects redox status on account of its antioxidative properties [8,23]. Notably, it can be used as a cancer marker [20,21]. According to the statistics, transplant recipients are highrisk cancer patients [4,5,37].…”

Section: Introductionmentioning

confidence: 99%

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Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

Wilk

Szypulska-Koziarska

Marchelek-Myśliwiec

et al. 2020

Biol Trace Elem Res

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There are data available in the literature on bioelement concentrations in the serum of various groups of patients; however, very little is known about the serum concentration of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu) in renal transplant patients treated with immunosuppressive drugs, including mycophenolate mofetil (MMF). Monitoring of serum bioelement concentrations in renal transplant recipients is of profound importance, as the proper bioelement levels seem to prolong the normal function of the transplanted organ. Thus, the aim of this current study was to examine and carry out comparative analysis involving serum concentrations of Se, Fe, Cu, and Zn of renal transplant recipients treated with MMF and without MMF. The material consisted of blood samples from 115 patients of the the city of Szczecin in the northwestern Poland. Serum Se, Fe, Cu, and Zn levels were quantified by inductively coupled mass spectroscopy (ICP-MS). Taking into account all patients, MMF increases Cu level. Cu and Fe concentrations were significantly higher in women treated with MMF; in group of younger patients treated with MMF, Se level was significantly lower comparing with those whose regimen did not include MMF. Additionally, MMF in combination with prednisone increased Se concentration in blood of transplant recipients. Our study highlights that trace elements should be monitored to allow for an early detection of trace elements deficits, which can easily be corrected for by an adjusted diet or supplemental intake.

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Section: Discussionmentioning

confidence: 61%

Section: Element Assaymentioning

confidence: 99%

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Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

Wilk

Szypulska-Koziarska

Marchelek-Myśliwiec

et al. 2020

Biol Trace Elem Res

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“…Arsenic and selenium levels in erythrocytes were quantified by inductively coupled mass spectroscopy (ICP-MS NexION 350D, Perkin Elmer) using methane to reduce polyatomic interferences, previously described by Lubinski et al [16]. Each sample was measured in duplicates in different analytical runs.…”

Section: Elements Assaymentioning

confidence: 99%

“…In contrast, selenium (Se) is a micronutrient of supreme importance for human health. Numerous studies have shown that the deficiency of this element is to be associated with, among others, diseases resulting from reduced immunity [15,16]. Se is believed to be the antioxidant trace element that is important in the biological defense against oxidative damage [17,18].…”

Section: Introductionmentioning

confidence: 99%

Arsenic and Selenium Profile in Erythrocytes of Renal Transplant Recipients

Wilk

Wiszniewska

2019

Biol Trace Elem Res

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Arsenic and selenium elements play extremely important roles in organisms. Too high As concentration in blood may lead to functional disorders within organs, including cancer. Arsenic is designated as a Group 1 human carcinogen by the International Agency for Research on Cancer that has established causal role of arsenic in cancers of the urinary bladder, lung, and skin in humans. In contrast, Se is believed to be the antioxidant trace element that is important in the biological defense against oxidative damage. We tested the hypothesis that immunosuppressive treatment based on mycophenolate mofetil (MMF), that is one of the most commonly used drug by renal transplant recipients, affects arsenic and selenium concentration in erythrocytes of renal transplant recipients. Current research was undertaken due to the fact that there are few studies on the concentration of chemical elements in the erythrocytes in kidney patients receiving immunosuppressive drugs. Monitoring of the concentration of chemical elements in the blood in patients who underwent kidney transplantation could be helpful, since chemical elements play an important role in many biological processes and it seems to be crucial in the prevention of cancer to which renal transplant recipients are more often exposed.The material consisted of blood from 115 renal transplant recipients of the the city of Szczecin in northwestern Poland. Arsenic and selenium levels in erythrocytes were quantified by inductively coupled mass spectroscopy.Men MMF+ had significantly higher As concentration than men MMF−. Se concentration was significantly higher in younger patients compared with older patients. The patients with lower creatinine level who used MMF had significantly higher As than MMF− patients. Patients whose therapy was based on MMF, cyclosporine A and glucocorticosteroids exhibited significantly higher concentration of As compared with patients whose regimen was based on MMF, tacrolimus, and glucocorticosteroids. This is the first study that demonstrates that regimen based on mycophenolate mofetil affects As and Se concentrations in erythrocytes in renal transplant recipients.

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Translational Nanotherapeutics Reprograms Immune Microenvironment in Malignant Pleural Effusion of Lung Adenocarcinoma

Song

Luo

Zheng

et al. 2021

Adv Healthcare Materials

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Malignant pleural effusion (MPE) remains a treatment bottleneck in advanced lung cancer, due to its complicated microenvironments and “cold” immunity. Therefore, the search for therapeutic drugs to transform MPE to functionally “hot” one could advance the development of effective immunotherapeutic strategy. Herein, translational selenium nanoparticles coated with immune‐modulating macromolecule lentinan (SeNPs@LNT) are designed to restore the dysfunctional immune cells in patient‐derived MPE microenvironment. Internalization of the SeNPs@LNT can effectively reduce the immunosuppressive status by enhancing the proliferation of CD4+ T cells and natural killer cells, and remodeling the tumor associated macrophages into tumoricidal M1 phenotype in MPE derived from patients presenting low Se levels in blood and pleural effusion. Th1, cytotoxic T cell, γδ T, and B cell functions are upregulated, and Th2, Th17, and Treg cells activity is downregulated. Furthermore, SeNPs@LNT can be gradually metabolized into SeCys2 to promote the production of metabolites associated with tumor growth inhibition and immune response activation in MPE microenvironment. In contrast, lung cancer markers and vitamin B6 metabolism are decreased. The translational SeNP‐based nanotherapeutic strategy restores functional “cold” MPE to “hot” MPE to activate the immune responses of various immune cells in MPE of lung cancer patients.

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Serum selenium levels predict survival after breast cancer

Cited by 43 publications

References 20 publications

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

Arsenic and Selenium Profile in Erythrocytes of Renal Transplant Recipients

Translational Nanotherapeutics Reprograms Immune Microenvironment in Malignant Pleural Effusion of Lung Adenocarcinoma

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