Serum selenium level in patients with colorectal cancer

Mikac-Dević, M.; Vukelić, Nada; Kljaić, Ksenija

doi:10.1007/bf02783996

Cited by 21 publications

(6 citation statements)

References 30 publications

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“…Epidemiological studies on individual dietary antioxidants such as vitamins and minerals and the risk of CRC have been conducted previously and produced inconsistent results 10‐31 . Randomized clinical trials evaluating the antioxidant supplementation did not yield consistent data in support of the protective effect against the development of CRC.…”

Section: Introductionmentioning

confidence: 99%

Composite dietary antioxidant index and the risk of colorectal cancer: Findings from the Singapore Chinese Health Study

Paragomi

Wang

et al. 2022

Intl Journal of Cancer

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Colorectal cancer (CRC) is a major contributor to cancer death globally. Several studies showed some protections by certain individual dietary antioxidants against CRC development. Epidemiologic data on the composite dietary antioxidant index (CDAI) in relation to CRC risk are sparse. Using the Singapore Chinese Health Study, an ongoing prospective cohort consisting of 61 321 cancer‐free participants aged 45 to 74 years at baseline, a food‐based CDAI was calculated according to a previously established and validated method that included six food‐sourced antioxidants including vitamins A, C and E, manganese, selenium and zinc. Cox proportional hazard regression method was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for CRC associated with various levels of CDAI with adjustment for multiple potential confounders. After an average of 17.5 years of follow‐up, 2140 participants developed CRC. HRs (95% CIs) of CRC for quartiles 2, 3 and 4 of CDAI were 0.94 (0.83‐1.07), 0.86 (0.75‐1.00) and 0.80 (0.66‐0.98), respectively, compared to the lowest quartile (Ptrend = .02). This inverse association between CDAI and CRC risk was more apparent in women or those without a history of diabetes, without family history of CRC, never smokers or overweight/obese individuals. However, none of the heterogeneity tests for the CDAI‐CRC risk association reached statistical significance. Our findings suggest that food‐based antioxidants may be beneficial for reducing the risk of CRC in the general population.

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Section: Introductionmentioning

confidence: 99%

Composite dietary antioxidant index and the risk of colorectal cancer: Findings from the Singapore Chinese Health Study

Paragomi

Wang

et al. 2022

Intl Journal of Cancer

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“…The rationale for this modification was based on the observation that organoselenium compounds have been shown to be effective in retarding tumorigenesis of several cancer types, including colon cancer (38–42), in both animal models and epidemiological studies. In addition, it has been demonstrated that most cancer patients, including colon cancer patients (43, 44), have lower serum selenium levels than healthy controls. Hence, ISC compounds combined the anticancer properties of both selenium and ITCs.…”

Section: Introductionmentioning

confidence: 99%

The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model

Sharma

Kline

Berg

et al. 2011

Clinical Cancer Research

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Purpose Prostate apoptosis response protein-4 (Par-4) sensitizes cells to chemotherapy; however, Akt1 inactivates Par-4. Previously we showed that Par-4 overexpressing colon cancer cells responded more readily to 5-FU than did wild type counterparts. In this study we investigated: 1) the effects of the Akt inhibitor, phenylbutyl isoselenocyanate (ISC-4), on tumor growth in nude mice and 2) bystander effect of Par-4 overexpressing cells on wild type tumor growth. Experimental design Mice (80) were injected with wild type HT29 human colon cancer cells in the right flank. Forty of the mice were also injected in the left flank with HT29 cells engineered to overexpress Par-4. Mice were treated with 5-FU, ISC-4, a combination, or vehicle. Results ISC-4 reduced tumor growth, with or without 5-FU. When Par-4 overexpressing tumors were present, wild type tumors grew more slowly than when no Par-4 overexpressing tumors were present. The level of Par-4 protein as well as the Par-4 binding protein, GRP78, was increased in wild type cells growing in the same mouse as Par-4 overexpressing tumors compared to wild type tumors growing without Par-4 overexpressing tumors. Conclusions Par-4 overexpressing tumors exhibited a bystander effect on wild type tumors growing distally in the same mouse. This suggests that gene therapy need not achieve total penetration to have a positive effect on tumor treatment. Inhibition of Akt with ISC-4 inhibited tumor growth and had a greater effect on cells overexpressing Par-4. The data indicate ISC-4 alone or in combination with Par-4 can greatly reduce tumor growth.

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“…Certain selenium-based compounds can selectively kill ALL cells by inducing cell cycle arrest and ROS-mediated apoptosis through the mitochondrial signaling pathway. In conclusion, it is clear that the serum selenium level in ALL patients decreases, and the efficacy of appropriate treatment methods may also be related to the increase in selenium level ( Mikac-Dević et al, 1990 ; Wu et al, 2017 ).…”

Section: Introductionmentioning

confidence: 93%

The progress in the relationship between trace elements and acute lymphoblastic leukemia

Wang

Huang²,

Lang³

et al. 2023

Front. Cell Dev. Biol.

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Trace elements are very important substances with low content in the human body. If the content of some trace elements changes, they are also related to diseases. Acute lymphoblastic leukemia (ALL) is a malignant blood tumor, and its relationship with trace elements has also been a concern by scholars. Not only have the trace element levels in ALL patients changed, but the efficacy of different treatment methods has also been linked to the corresponding trace element changes. The characteristics of ALL may be related to the dysregulation of differentiation and proliferation of lymphoid precursor cells. Cell proliferation and differentiation are often affected by changes in DNA levels. However, trace elements are involved in DNA damage and repair mechanisms. In recent years, as an increasing number of studies believe that ALL is related to the abnormal metabolism of trace elements in the body, this paper intends to discuss the research progress on the relationship between trace elements and ALL to provide more information on trace elements for the diagnosis, treatment, and prevention of ALL.

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Serum selenium level in patients with colorectal cancer

Cited by 21 publications

References 30 publications

Composite dietary antioxidant index and the risk of colorectal cancer: Findings from the Singapore Chinese Health Study

Composite dietary antioxidant index and the risk of colorectal cancer: Findings from the Singapore Chinese Health Study

The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model

The progress in the relationship between trace elements and acute lymphoblastic leukemia

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