Serum samples from patients with active psoriasis enhance lymphocyte-induced angiogenesis and modulate endothelial cell proliferation

Characterization of Lymphocyte-Dependent Angiogenesis Using a SCID Mouse: Human Skin Model of Psoriasis

“…Previous investigators have observed that peripheral bloodderived mononuclear cells from psoriatic patients, or serum from psoriatic patients, could induce angiogenesis (Majewski et al, 1985(Majewski et al, , 1987; however, the exact cell-type (i.e., T cell subset), or the molecules responsible for this angiogenic response, were not further characterized. More recently, attempts have been made to de®ne the cytokine network in psoriasis, and to identify angiogenic as well as angiostatic cytokines that may contribute to the vascular changes present in psoriatic plaques (Nickoloff, 1991).…”

IgA Deficiency and Psoriasis: Relevance of IgA in the Pathogenesis of Psoriasis

“…Functionally, serum factors may modulate chemotaxis of monocytes and neutrophils and may interfere with angioneogenesis and proliferation of fibroblasts [3][4][5][6], Non-cel lular systemic factors which might be involved in the immunopathogenesis of psoriasis are numerous. It has been suggested that IgA and IgA immune complexes are in volved in the pathogenesis of psoriasis [7][8][9].…”

Abrogated NK‐cell lysis of human papillomavirus (HPV)‐16‐bearing keratinocytes in patients with pre‐cancerous and cancerous HPV‐induced anogenital lesions

“…The sera obtained from healthy controls or patients were heat-decomplemented at 56°C for 30 min and tested for their ability to influence NCMC of PBMC from normal healthy donors of blood group 0, according to Majewski et al (1987) with some modifications. Briefly, 2 x lo7 PBMC were incubated in 2 ml of HBSS supplemented with 25% of the tested serum for 3 hr at 37°C.…”