2001
DOI: 10.1055/s-2001-14297 View full text |Buy / Rent full text
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Abstract: Background: Cerebral injury after Cardiopulmonary bypass (CPB) is still a serious and unpredictable complication. The S-100b serum marker has been suggested as potentially useful in the detection of cerebral injury during and after CPB. Direct comparisons of whether laminar or pulsatile pump flow in CABG leads to higher S-100b values and which type might be more neuroprotective have not been made so far. Methods: All 21 patients of the study were undergoing CABG for the first time and had no history of cerebra… Show more

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“…Pulsatile flow lowers cerebral destruction than laminar flow [ 50 ] . S100 was nonsignificantly higher in cold than in warm CPB patients [ 63 ] .The S100β rise was significantly less in patients administered sevoflurane in comparison to total intravenous anesthesia [ 64 ] .…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Pulsatile flow lowers cerebral destruction than laminar flow [ 50 ] . S100 was nonsignificantly higher in cold than in warm CPB patients [ 63 ] .The S100β rise was significantly less in patients administered sevoflurane in comparison to total intravenous anesthesia [ 64 ] .…”
Section: Discussionmentioning
“…Several biochemical markers have been associated with ischemic or traumatic insults to the brain. 20,26,[31][32][33][34][35][36][37][38][39][40][41][42][43] The association of such biochemical markers with hypoxemia, ischemia, stroke, and hypothermia is already established in studies of adult patients. Only in the last several years, interest has grown to explore the association of these markers with TBI in children.…”
Section: Discussionmentioning
“…Fakat bu araştırmaların aksine, Kusch ve ark. [49] pulsatil ve nonpulsatil perfüzyonun karşılaştı-rılması sonucunda, ortalama S100b düzeyinin pulsatil akım uygulananlarda daha az yükseldiği sonucuna varmışlardır.…”
Section: Nöron Spesifik Enolazunclassified
“…Erken dönemde (KPB'den sonra ilk 5 saat) yaş, dolaşım arresti ve KPB süresi, aort kros-klemp zamanı, ameliyat öncesi serebrovasküler hastalıklar, aort kanülasyonu sırasında oluşan emboli sayısı, ameliyat sonrası serebral komplikasyonlar ve ameliyat öncesi renal hasar; geç dönemde (KPB'den sonra 15-48 saat arası) perioperatif serebral komplikasyonlar, dolaşım arresti ve serebral perfüzyon yokluğunun süresi, çıkan aort aterosklerozu ve yenidoğanlar gibi etkenlerin etkili olduğu Hemoliz Nöron spesifik enolaz artar, S100b etkilenmez [41] Kardiyotomi aspirasyon S100b artar, nöron spesifik enolaz etkilenmez [9] Koroner arter baypas greftleme, kapak replasman cerrahisi Nöron spesifik enolaz ve S100b artar [40] Kardiyopulmoner baypas Nöron spesifik enolaz ve S100b artar [45] Aprotinin Nöron spesifik enolaz ve S100b etkilenmez [9] MgSO 4 infüzyonu S100b azalır, nöron spesifik enolaz bilinmiyor [43] Dopamin infüzyonu S100b artar, nöron spesifik enolaz bilinmiyor [43] Heparin, protamin, propofol S100b etkilenmez, nöron spesifik enolaz bilinmiyor [44] Metilprednizolon Nöron spesifik enolaz azalır, S100b bilinmiyor [45] Kardiyopulmoner baypas süresi Nöron spesifik enolaz ve S100b artar [21,47] Nöron spesifik enolaz etkilenmez [45] S100b artar [51] Off-pump koroner arter baypas greftleme S100b azalır, nöron spesifik enolaz bilinmiyor [47] Pulsatil akıma karşı nonpulsatil akım S100b etkilenmez, nöron spesifik enolaz bilinmiyor [46] S100b azalır, nöron spesifik enolaz bilinmiyor [49] Yaş S100b etkilenmez [48 Nöron spesifik enolaz ve S100b artar [21] Perfüzyon süresi S100b artar [34] S100b etkilenmez [48] Aort kros-klemp zamanı S100b etkilenmez [48] Nöron spesifik enolaz ve S100b etkilenmez [50] Nöron spesifik enolaz ve S100b artar [21] Yoğun bakımda yatış süresi, cinsiyet S100b etkilenmez, nöron spesifik enolaz bilinmiyor [48] Cerrahi süresi Nöron spesifik enolaz ve S100b etkilenmez [50] Apoe4 alleli Nöron spesifik enolaz ve S100b artar [54] düşünülmektedir. [24] Özatik ve ark.…”
Section: Nöron Spesifik Enolazunclassified