Serum proteins neutralize the toxic effect of lysophosphatidyl choline

Structural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic properties

“…To list only a few examples, LPA, transported by albumin, is responsible for the stress fibre formation [ 62 ]. Moreover, by the interactions with LPC, serum albumin increases the availability of LPCs for their receptors [ 27 , 51 , 63 – 65 ]. Activation of osteoblast development during bone repair process is linked with the action of LPAs bound to albumin [ 66 ].…”

Structural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic properties

“…To list only a few examples, LPA, transported by albumin, is responsible for the stress fibre formation [ 62 ]. Moreover, by the interactions with LPC, serum albumin increases the availability of LPCs for their receptors [ 27 , 51 , 63 – 65 ]. Activation of osteoblast development during bone repair process is linked with the action of LPAs bound to albumin [ 66 ].…”

Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4

“…These forms may be active in some nonreceptor-mediated functions of LPC, such as delivery of fatty acids and choline (22), but may be in a form unavailable for receptor activation. It has been shown that some of the effects of LPC are decreased in the presence of albumin (42). Thus, the functionally available concentration of LPC in vivo, and the activation of LPC receptors may be controlled by the lower concentrations of free LPC.…”

Regulation of Eosinophil Adhesion by Lysophosphatidylcholine via a Non–Store-Operated Ca2+ Channel

“…Previous investigations have shown that albumin binds to lysophospholipids, thereby sequestering these lipids away from the cell surface (41,42). We therefore examined the effect of increasing concentrations of soluble albumin on eosinophil adhesion caused by LPC.…”

Structural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic properties

“…To list only a few examples, LPA, transported by albumin, is responsible for the stress fibre formation [ 62 ]. Moreover, by the interactions with LPC, serum albumin increases the availability of LPCs for their receptors [ 27 , 51 , 63 – 65 ]. Activation of osteoblast development during bone repair process is linked with the action of LPAs bound to albumin [ 66 ].…”

Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4

“…These forms may be active in some nonreceptor-mediated functions of LPC, such as delivery of fatty acids and choline (22), but may be in a form unavailable for receptor activation. It has been shown that some of the effects of LPC are decreased in the presence of albumin (42). Thus, the functionally available concentration of LPC in vivo, and the activation of LPC receptors may be controlled by the lower concentrations of free LPC.…”

Regulation of Eosinophil Adhesion by Lysophosphatidylcholine via a Non–Store-Operated Ca2+ Channel

“…Previous investigations have shown that albumin binds to lysophospholipids, thereby sequestering these lipids away from the cell surface (41,42). We therefore examined the effect of increasing concentrations of soluble albumin on eosinophil adhesion caused by LPC.…”

Structural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic properties

“…To list only a few examples, LPA, transported by albumin, is responsible for the stress fibre formation [ 62 ]. Moreover, by the interactions with LPC, serum albumin increases the availability of LPCs for their receptors [ 27 , 51 , 63 – 65 ]. Activation of osteoblast development during bone repair process is linked with the action of LPAs bound to albumin [ 66 ].…”

Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4

“…These forms may be active in some nonreceptor-mediated functions of LPC, such as delivery of fatty acids and choline (22), but may be in a form unavailable for receptor activation. It has been shown that some of the effects of LPC are decreased in the presence of albumin (42). Thus, the functionally available concentration of LPC in vivo, and the activation of LPC receptors may be controlled by the lower concentrations of free LPC.…”

Regulation of Eosinophil Adhesion by Lysophosphatidylcholine via a Non–Store-Operated Ca2+ Channel

“…Previous investigations have shown that albumin binds to lysophospholipids, thereby sequestering these lipids away from the cell surface (41,42). We therefore examined the effect of increasing concentrations of soluble albumin on eosinophil adhesion caused by LPC.…”