2016
DOI: 10.18632/aging.101091
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Abstract: The latent variable “δ” (for “dementia”) appears to be uniquely responsible for the dementing aspects of cognitive impairment. Age, depressive symptoms, gender and the apolipoprotein E (APOE) ε4 allele are independently associated with δ. In this analysis, we explore serum proteins as potential mediators of age's specific association with δ in a large, ethnically diverse longitudinal cohort, the Texas Alzheimer's Research and Care Consortium (TARCC). 22 serum proteins were recognized as partial mediators of ag… Show more

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Cited by 10 publications
(14 citation statements)
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References 68 publications
(70 reference statements)
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“…The interleukins 3 (IL-3), 13 (IL-3), serum amyloid protein, and THPO loaded inversely on INFLAMMATION and thus had salutary associations with cognitive performance, consistent with their roles as anti-inflammatory cytokines in the literature. INFLAMMATION's factor weights all replicated in a random split of TARCC's sample (Dchi square 5 8.0 [11], P . .50).…”
Section: Resultsmentioning
confidence: 99%
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“…The interleukins 3 (IL-3), 13 (IL-3), serum amyloid protein, and THPO loaded inversely on INFLAMMATION and thus had salutary associations with cognitive performance, consistent with their roles as anti-inflammatory cytokines in the literature. INFLAMMATION's factor weights all replicated in a random split of TARCC's sample (Dchi square 5 8.0 [11], P . .50).…”
Section: Resultsmentioning
confidence: 99%
“…INFLAMMATION accounts for 5%–10% of dT2A's variance, which we have previously shown to be strongly associated with CDR‐SB and the diagnosis of clinical “AD” [16]. Its effect on δ is independent of other recognized dementia risks (e.g., age, APOE, and depression) which are mediated by yet other serum proteins [11–13]. In their aggregate, INFLAMMATION and those dementia risks account for between 24% (ADNI) to 38% (TARCC) of dT2A's variance.…”
Section: Discussionmentioning
confidence: 99%
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“…Their associations with clinical dementia and dementia conversion may thereby be constrained to biological processes that affect intelligence. We recently identified serum proteins mediators of Age’s [ 17 ] and ε4’s [ 18 ]-specific associations with δ.…”
Section: Introductionmentioning
confidence: 99%