2014
DOI: 10.18632/aging.100630
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Abstract: As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in p… Show more

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Cited by 108 publications
(105 citation statements)
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References 51 publications
(58 reference statements)
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“…In addition, the long-lived mouse models exhibited elevated levels of SM (in particular C14:0 SM, C16:0 SM, C18:0 SM and C18:1 SM), which also showed positive correlation in longevity in the mammalian species dataset. Previously, SM levels were reported to be low in old mice but at normal levels in those under chronic CR (De Guzman et al, 2013) and were found to be high in the serum of centenarians (Montoliu et al, 2014). High SM levels are also associated with human female familial longevity (Gonzalez-Covarrubias et al, 2013).…”
Section: Resultsmentioning
confidence: 99%
“…In addition, the long-lived mouse models exhibited elevated levels of SM (in particular C14:0 SM, C16:0 SM, C18:0 SM and C18:1 SM), which also showed positive correlation in longevity in the mammalian species dataset. Previously, SM levels were reported to be low in old mice but at normal levels in those under chronic CR (De Guzman et al, 2013) and were found to be high in the serum of centenarians (Montoliu et al, 2014). High SM levels are also associated with human female familial longevity (Gonzalez-Covarrubias et al, 2013).…”
Section: Resultsmentioning
confidence: 99%
“…Indeed, metabolomics has been recently used for the identification of novel biomarkers and the elucidation of novel biological pathways for a variety of diseases (15,17). For example, Collino and co-workers studied the metabolic phenotype of longevity by comparing the metabolomics profile of centenarians, elderly, and young people (18,19). In this study, alterations of the glycerophoshpolipids and sphingolipids were observed in the centenarian population, helping elucidate mechanistic routes for the longevity phenotype and demonstrating the power of this method.…”
mentioning
confidence: 87%
“…The abundances of individual metabolites change with age in several species, including worms [67,68], flies [35,69], mice [7072], and humans [57,73,74]. In the same vein, differences in abundances of individual metabolites have been associated with long life across multiple species, including work on long-lived mutant worms [75], longevity selected flies [76], calorie restricted and long-lived mutant mice [77], and long-lived human populations [7880]. Interestingly, fewer studies have attempted to find protein biomarkers of ageing or longevity, and those studies that have been carried out have found mixed results.…”
Section: Proteomics and Metabolomics As Ageing Biomarkersmentioning
confidence: 99%