Serum Prealbumin: Polymorphism in Man

Fagerhol, Magne K.; Braend, M.

doi:10.1126/science.149.3687.986

Cited by 110 publications

(23 citation statements)

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“…A severe deficient level of al-antitrypsin in serum has been found to be associated with pulmonary emphysema (Laurell and Eriksson, 1963) and liver cirrhosis (Sharp et aL, 1969). Fagerhol and Braend (1965) first described genetic variants of this protein using acid starch gel electrophoresis. More than 24 alleles have so far been identified.…”

Section: Introductionmentioning

confidence: 99%

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

et al. 1979

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SummarySerum a~-antitrypsin phenotypes were determined by polyacrylamide gel slab isoelectric focusing in a sample from 1,271 unrelated healthy Japanese living in Tokyo. Three common Pi M subtypes (MIM~, M1M~ and M2M2) were found, and the allele frequencies estimated (Pim= 0.83, Pi~Z=0.17) were found to be similar to those observed in the European populations. A large Z ~ value, however, may indicate the presence of further microheterogeneity among Pi M subtypes. In contrast with Pi M subtypes, rare variants were found only in 0.55~ of the samples examined, and no Z gene was detected. A new fast variant of a~-antitrypsin named Pi Erokyo is reported.

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Section: Introductionmentioning

confidence: 99%

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

et al. 1979

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“…In 1965, Fagerhol and Braend [3] first re cognized genetic variation using acidstarch gel electrophoresis. Subsequent re ports in the literature over the next few years further documented and identified such genes as PUM, PUS, PUF, PI*Z, PUP, and PI*I.…”

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confidence: 99%

Distribution of α<sub>1</sub>-Antitrypsin Variants in a US White Population

Dykes¹,

Miller²,

Polesky³

1984

Hum Hered

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A white population from the State of Minnesota of primarily German and Scandinavian heritage was subtyped for α₁-antitrypsin variants using isoelectric focusing. The frequencies of the genes PPM1 (0.724), PI*M2 (0.137) and PI*M3 (0.095) were consistent with those for white populations documented in the literature from Northern Europe. Other genes identified in the study were PI*F, PPI, PPP, PPS and PPZ.

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“…The serum d^anti trypsin (etj-at) has been shown to occur in a great num ber of phenotypes when a special starch gel electrophoresis in acidic buffer is used [F a g e rh o l and Braend, 1965], Under these conditions, the pattern of di-antitrypsin genetic variants consists of three major and five minor protein zones in front of the albumin [F a g e rh o l, 1969]. These variants constitute the so-called Pi system, since a^at is one of the major protease inhibitors of human serum [Jacobson, 1955].…”

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confidence: 99%

Pi Phenotypes in Greeks

Fertakis¹,

Tsourapas²,

Douratsos³

et al. 1974

Hum Hered

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Pi serum types were determined by starch gel electrophoresis in 504 unrelated healthy adults representative of the Greek population. Gene frequencies were as follows: Pi^M, 0.960; Pi^S, 0.028; Pi^Z, 0.002; Pi^F, 0.006; and Pi^V, 0.002. No significant heterogeneity was found in this material, and distribution of Pi phenotypes is in good agreement with the Hardy-Weinberg equilibrium. Pi^I, Pi^W, Pi^X, and Pi^P alleles were not found.

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Serum Prealbumin: Polymorphism in Man

Abstract: Serums from 390 Norwegian blood donors and 31 members of two families were studied by starch gel electrophoresis. Five different prealbumin phenotypes were found, indicating a genetic theory of three codominant alleles for which the terms Pr(F), Pr(M), and Pr(S) are proposed.

Cited by 110 publications

References 3 publications

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

Distribution of α<sub>1</sub>-Antitrypsin Variants in a US White Population

Pi Phenotypes in Greeks

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Serum Prealbumin: Polymorphism in Man

Abstract: Serums from 390 Norwegian blood donors and 31 members of two families were studied by starch gel electrophoresis. Five different prealbumin phenotypes were found, indicating a genetic theory of three codominant alleles for which the terms Pr(F), Pr(M), and Pr(S) are proposed.

Cited by 110 publications

References 3 publications

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

Distribution of &alpha;<sub>1</sub>-Antitrypsin Variants in a US White Population

Pi Phenotypes in Greeks

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Distribution of α<sub>1</sub>-Antitrypsin Variants in a US White Population