Serum parathyroid hormone level is elevated in some patients with disorders of keratinization

Harlequin Ichthyosis

“…6), JUNE 2011the diseased epidermis and avoidance of exposure to UV radiation due to the disease. 21 Juvenile idiopathic arthritis is a rare inflammatory arthritis. In addition to the 3 cases reported herein, another patient with HI aged 6 years is described in the literature who developed rheumatoid factor-positive polyarthritis.…”

Bone Densities in Patients Receiving Isotretinoin for Cystic Acne

“…24,25 "Lucent" bones have been described 24,26 on radiographs, and a spontaneous vertebral fracture developed in 1 person receiving isotretinoin long term. 27 Nonetheless, no relation between isotretinoin use and osteoporosis was identified in several recent studies. [28][29][30] To understand better the effects of synthetic retinoids on bone, we prospectively investigated bone density and calcium metabolism in young men who received isotretinoin for cystic acne.…”

A double-blind, randomized, Phase III, multicenter study in 358 pediatric subjects receiving isotretinoin therapy demonstrates no effect on pediatric bone mineral density

“…At least two single-center studies have described bone lucency, or osteopenia, in subjects treated with isotretinoin [5,6]. Multiple studies with similar average treatment doses to those reported in this study have not demonstrated a decrease in the lumbar spine and hip BMD using dual X-ray absorptiometry (DXA) in pediatric or adult subjects [7][8][9][10][11].…”

“…However, as a result of reported adverse effects, it has been used with caution in the pediatric patient population. While the most severe adverse effects have been reported outside the skeletal system, purported skeletal adverse effects include osteopenia, bone mineral density changes (BMD) in the spine and proximal femur, enthesopathy, and premature epiphyseal closure [2][3][4][5][6]. The growing skeleton is more sensitive to agents effecting bone development, which may limit isotretinoin utilization [1].…”