Serum osteoprotegerin level is positively associated with peripheral artery disease in patients with peritoneal dialysis

Lin, Wei‐Chen; Tsai, Jen-Pi; Lai, Yu‐Hsien; Lin, Yu‐Li; Kuo, Chiu‐Huang; Wang, Chih‐Hsien; Hsu, Bang‐Gee

doi:10.1080/0886022x.2020.1714654

Cited by 10 publications

(18 citation statements)

References 32 publications

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“…Kt/V and urea reduction ratio (URR) using a formal and single-compartment dialysis urea kinetic model were used to calculate adequacy of HD. Serum OPG (eBioscience Inc., San Diego, CA, USA) and intact parathyroid hormone (iPTH) levels (Abcam, Cambridge, MA, USA) were measured by using a commercially available enzyme immunoassay or enzyme-linked immunosorbent assay, respectively [ 23 ]. Body mass index (BMI) was calculated as (body weight)/(body height) 2 (kg)/(m) 2 [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis

Wang

Hsu

et al. 2021

Medicina

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Background and Objectives: Osteoprotegerin (OPG), a potent osteoclast activation inhibitor, decreases bone resorption and plays a role in mediating bone mineral density (BMD). Our aim was to evaluate the relationship between BMD and serum OPG in maintenance hemodialysis (MHD) patients. Materials and Methods: Fasting blood samples were obtained from 75 MHD patients. BMD was measured by dual-energy X-ray absorptiometry in lumbar vertebrae (L2–L4). The WHO classification criteria were applied to define osteopenia and osteoporosis. A commercial enzyme-linked immunosorbent assay was used to measure serum OPG values. Results: Among all MHD patients, seven (9.3%) and 20 patients (26.7%) were defined as osteoporosis and osteopenia, respectively. Female patients had lower lumbar BMD than males (p = 0.002). Older age (p = 0.023), increased serum OPG (p < 0.001) urea reduction rate (p = 0.021), Kt/V (p = 0.027), and decreased body mass index (p = 0.006) and triglycerides (p = 0.020) were significantly different between the normal, osteopenia, and osteoporosis groups. Lumbar spine BMD was positively correlated with body mass index (BMI) (p < 0.001) but negatively correlated with OPG (p < 0.001) and age (p = 0.003). After grouping patients into T scores < −1 and < −2.5, female sex and OPG (adjusted odds ratio [aOR] 1.022, 95% confidence interval [C.I.] 1.011–1.034, p < 0.001) were predictors of T scores < −1, whereas only OPG was predictive of T scores < −2.5 (aOR 1.015, 95% C.I. 1.005–1.026, p = 0.004) by multivariate stepwise logistic regression analysis. The areas under the curve for predicting T scores < −1 or < −2.5 were 0.920 (95% C.I. 0.834–0.970, p < 0.001) and 0.958 (95% C.I. 0.885–0.991, p < 0.001), respectively. Conclusions: Increased serum OPG negatively correlated with lumbar BMD and could be a potential biomarker predictive of osteoporosis in MHD patients.

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Section: Methodsmentioning

confidence: 99%

Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis

Wang

Hsu

et al. 2021

Medicina

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“…Intact parathyroid hormone (iPTH) levels were measured by a commercially available enzyme-linked immunosorbent assay (catalog number: NM59041; IBL International, Hamburg, Germany). 11–13…”

Section: Methodsmentioning

confidence: 99%

“…Blood pressure was measured using the oscillometric method in both arms and ankles for three times, with the patient in the supine position, and readings were obtained from brachial, dorsalis pedis, and posterior tibial arteries (VaSera VS-1000; Fukuda Denshi, Tokyo, Japan). 11 Right or left ABI was calculated as the ratio of the highest-measured systolic blood pressure in right or left ankle (dorsalis pedis or posterior tibial artery) to the highest-measured systolic blood pressure in brachial artery of either arm. Real-time electrocardiography was documented for more than 15 min.…”

Section: Ankle-brachial Index Measurementsmentioning

confidence: 99%

“…Intact parathyroid hormone (iPTH) levels were measured by a commercially available enzymelinked immunosorbent assay (catalog number: NM59041; IBL International, Hamburg, Germany). [11][12][13] High-performance liquid chromatography-mass spectrometry Total IS levels were measured by modified liquid chromatography-mass spectrometry. [12][13][14] Briefly, 100 µL serum was added to a 1.5-mL centrifuge tube containing 100 µL of 50 mM sodium phosphate dibasic heptahydrate solution.…”

Section: Biochemical Investigationsmentioning

confidence: 99%

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Positive correlation of serum indoxyl sulfate level with peripheral arterial disease in hemodialysis patients

Chiu

Lin

et al. 2021

Vascular

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Objectives Indoxyl sulfate, known for its cardiovascular toxicity, is associated with vascular and coronary artery diseases and increased mortality. Peripheral arterial disease, defined by low ankle–brachial index, is associated with increased mortality in patients on hemodialysis. The present study aimed to determine the relationship between the serum indoxyl sulfate level and peripheral arterial disease in patients on maintenance hemodialysis. Methods The present cross-sectional, single-center study included 75 patients on maintenance hemodialysis. Serum indoxyl sulfate levels were determined by high-performance liquid chromatography–mass spectrometry. Ankle–brachial index values were measured using an automated oscillometric device. Patients with ankle–brachial indexes of < 0.9 were categorized into the low ankle–brachial index group. Results In the study cohort, 12 of the 75 patients (16.0%) had low ankle–brachial indexes. The rates of diabetes mellitus ( p = 0.010) as well as the serum levels of C-reactive protein ( p < 0.001) and indoxyl sulfate ( p < 0.001) were higher in the low ankle–brachial index group than the normal ankle–brachial index group. The multivariable logistic regression analysis revealed that serum levels of indoxyl sulfate (odds ratio = 1.123, 95% confidence interval 1.011–1.249, p = 0.031) and C-reactive protein (each 0.1 mg/dL increase, odds ratio = 1.169, 95% confidence interval 1.018–1.343, p = 0.027) were independently associated with peripheral arterial disease in patients on maintenance hemodialysis. Conclusions Serum indoxyl sulfate levels were associated with peripheral arterial disease in patients on maintenance hemodialysis.

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“…In this regard, elevated circulating OPG level has been proposed as a predictor of cardiovascular [ 17 , 18 ] and all-cause [ 19 , 20 ] mortality in patients with CKD. Serum OPG level is positively associated with peripheral artery disease, arterial stiffness, and arterial calcification in patients with end-stage renal disease [ 21 , 22 , 23 , 24 ]. Moreover, kidney transplantation decreases circulating level of OPG [ 25 ], and early post-transplantation circulating OPG level in serum predicts long-term patient survival up to 8 years [ 26 ], collectively suggesting a prognostic impact of circulating OPG level in patients with renal insufficiency.…”

Section: Introductionmentioning

confidence: 99%

Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease

Suh

Choi

et al. 2021

JCM

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Circulating osteoprotegerin (OPG) is a biomarker for cardiovascular complications that are closely related to chronic kidney disease (CKD). To investigate the association between circulating OPG level with long-term visit-to-visit blood pressure variability (BPV) in patients with pre-dialysis CKD, a total of 1855 subjects with CKD from stage 1 to pre-dialysis stage 5 from a prospective cohort were analyzed. Long-term visit-to-visit BPV was determined by average real variability (ARV), standard deviation (SD), and coefficient of variation (CoV) of systolic and diastolic blood pressure (SBP and DBP). ARV of SBP (Adjusted β coefficient 0.143, 95% confidence interval 0.021 to 0.264) was significantly associated with serum OPG level. Although SD and CoV of SBP were not significantly associated with serum OPG level in multivariate linear regression analyses, restricted cubic spline visualized the linear correlation of serum OPG level with all of ARV, SD, and CoV. The association between serum OPG level and DBP variability was not significant. Subgroup analyses revealed that the association of serum OPG with BPV is more prominent in the subjects with Charlson comorbidity index ≤3 and in the subjects without history of diabetes mellitus. In conclusion, circulating OPG level is potentially associated with long-term visit-to-visit BPV in patients with pre-dialysis CKD.

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Serum osteoprotegerin level is positively associated with peripheral artery disease in patients with peritoneal dialysis

Cited by 10 publications

References 32 publications

Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis

Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis

Positive correlation of serum indoxyl sulfate level with peripheral arterial disease in hemodialysis patients

Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease

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