Serum myeloperoxidase activity and oxidative stress in patients with acute brucellosis

Karahocagil, Mustafa Kasım; Aslan, Mehmet; Ceylan, Mehmet Reşat; Çıkman, Aytekin; Sünnetçioğlu, Mahmut; Küçükoğlu, Mehmet Emin; Taşkın, Abdullah

doi:10.1016/j.clinbiochem.2012.03.017

Cited by 17 publications

(16 citation statements)

References 25 publications

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“…They also found increased oxidant capacity and decreased antioxidant parameters before therapy, and they obtained increased antioxidant levels after treatment (36). Therefore, it is well known that brucellosis is involved in enhanced free radical production and a depleted antioxidant system (10,(33)(34)(35)(36). Oxidative burst and oxidative killing in macrophages have a significant and primary role in the control of Brucella pathogens (9).…”

Section: Discussionmentioning

confidence: 99%

Impaired Thiol-Disulfide Balance in Acute Brucellosis

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Impaired Thiol-Disulfide Balance in Acute Brucellosis

et al. 2017

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“…MPO activity as an assessment of neutrophil influx was measured according to established protocols[31]–[33].In brief, tissue was homogenized in 0.5 ml of 50 mM potassium phosphate buffer (pH 7.4) and centrifuged at 10,000 g at 4°C for 30 min. The remaining pellet was resuspended in 0.5 ml of 50 mM potassium buffer pH 6.0 with 0.5% hexadecyltrimethylammonium bromide, sonicated on ice, and then centrifuged at 12,000 g at 4°C for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Effect of Carbon Monoxide-Releasing Molecules II-liberated CO on Suppressing Inflammatory Response in Sepsis by Interfering with Nuclear Factor Kappa B Activation

Qin

Zhang

et al. 2013

PLoS ONE

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Sepsis continues to be a challenge in clinic. The rates of mortality in sepsis patients remain high. The present study aimed to investigate the effects and the underlying mechanisms of carbon monoxide-releasing molecules II (CORM-2)-liberated CO on suppressing inflammatory response in sepsis. It was shown that treatment of septic mice with CORM-2 attenuated PMN accumulation, downregulated cytokines production, inhibited expressions of iNOS and NF-κB activity in the lung and liver. In parallel, CORM-2 prevented activation of NF-κB in LPS-stimulated HUVEC. This was accompanied by a decrease in ROS and NO production, expression of ICAM-1 and subsequent PMN adhesion to HUVEC. These findings demonstrated that CORM-released CO attenuates inflammatory responses by interfering with NF-κB activation and therefore decreasing the expression of ICAM-1 and NO production, attenuating the oxidative stress and inflammation in sepsis.

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“…The cytokineinduced changes in lipid and lipoprotein metabolism include reduction in serum levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoproteins (apo) A-I, B and lipoprotein (a), and an increase in triglyceride and apoE concentrations [13]. The presence of increased myeloperoxidase activity and decreased catalase activity, representing increased oxidative stress, may also play a role in atherosclerotic processes in brucellosis [23].…”

Section: Discussionmentioning

confidence: 99%

Transient dyslipidemia in childhood brucellosis

Kara¹

2019

Ann Clin Anal Med

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Aim: Brucellosis involves almost all organs, although the endocrine organs are more protected. Impairment of lipid metabolism is also a little-known problem. We aimed to investigate hormone levels and lipid metabolism in children with acute brucellosis. Material and Method: Forty-six children with acute brucellosis, who had never been treated for the disease, and 39 healthy children were prospectively investigated. They were compared in terms of liver functions, serum lipid profiles, and hormone levels. Results: The patients had higher levels of AST, ALT, and GGT (p=0.04, p=0.01, and p=0.01, respectively). The patients also had higher cholesterol and triglyceride, and lower LDL and HDL levels than healthy children. The difference between triglyceride levels was statistically significant (p=0.04). Serum hormone levels were similar between groups. With antibiotic treatment and lifestyle modifications, all abnormal laboratory parameters returned to normal. Discussion: Children with acute brucellosis should be monitored for dyslipidemia, which can be relieved with antibiotics and lifestyle changes without using lipid lowering agents. Investigation of hormone levels in these patients is necessary only if signs and symptoms suggest an endocrine abnormality.

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Serum myeloperoxidase activity and oxidative stress in patients with acute brucellosis

Cited by 17 publications

References 25 publications

Impaired Thiol-Disulfide Balance in Acute Brucellosis

Impaired Thiol-Disulfide Balance in Acute Brucellosis

Effect of Carbon Monoxide-Releasing Molecules II-liberated CO on Suppressing Inflammatory Response in Sepsis by Interfering with Nuclear Factor Kappa B Activation

Transient dyslipidemia in childhood brucellosis

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