Asian Pac J Cancer Prev, 15 (21), 9459-9465
IntroductionColorectal cancer (CRC) is one of the most frequent malignances in the world. It is the third most common cancer and the third leading cause of cancer death in the United State (Siegel et al., 2014). Although dramatic reduction in cancer mortality and prolong patient survival with surgical resection and chemotherapy has been achieved clinically (Yan et al., 2010). However, tumor recurrence and the chemoresistance is the main factor for the failure of therapy (Chang, 2011). CRC arises through the progressive accumulation of mutations in oncogenes and tumor-suppressor genes (Sansom et al., 2007; Petrova et al., 2008). Despite several genes have being proved that relate to genesis of CRC, the exact mechanisms underlying he development and progression CRC are still poorly understood (Goel and Boland, 2010). Throughout the articles relate to CRC in the journal ACJCP over the past two years, it is not difficult to find that the novel molecular markers with potential of treatment and prognosis have captured more and more attention (Chen et al., 2013; Zhu et al., 2013). Given this consideration, it is imperative to seek out a key gene associated with the progression and pathogenesis.Structural maintenance of chromosomes (SMC)