2008
DOI: 10.1001/jama.299.3.308
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Serum Micronutrient Concentrations and Decline in Physical Function Among Older Persons

Abstract: Context Maintaining independence of older persons is a public health priority, and identifying the factors that contribute to decline in physical function is needed to prevent or postpone the disablement process. The potential deleterious effect of poor nutrition on decline in physical function in older persons is unclear. Objective To determine whether a low serum concentration of micronutrients is associated with subsequent decline in physical function among older men and women living in the community. Desig… Show more

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Cited by 113 publications

(89 citation statements)
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“…Participants with greater plasma concentrations of vitamin E (α-tocopherol) exhibited lower plasma levels of inflammation together with better health status, as determined by higher scores of mental and physical quality of life on the SF-36 questionnaire. This finding is consistent with recent data showing an association between low serum concentrations of α-tocopherol and subsequent decline in physical function in a population-based sample of community-living elders ( 4 ) . In the present study, plasma concentrations of α-tocopherol correlated with both the mental and physical components of quality of life, suggesting the involvement of vitamin E in multiple dimensions of health and wellbeing.…”
Section: Discussion
supporting
confidence: 93%
How this paper cites the one you are viewing
“…Participants with greater plasma concentrations of vitamin E (α-tocopherol) exhibited lower plasma levels of inflammation together with better health status, as determined by higher scores of mental and physical quality of life on the SF-36 questionnaire. This finding is consistent with recent data showing an association between low serum concentrations of α-tocopherol and subsequent decline in physical function in a population-based sample of community-living elders ( 4 ) . In the present study, plasma concentrations of α-tocopherol correlated with both the mental and physical components of quality of life, suggesting the involvement of vitamin E in multiple dimensions of health and wellbeing.…”
Section: Discussion
supporting
confidence: 93%
How this paper cites the one you are viewing
“…Some studies have however shown an association between low 25OHD and loss of muscle strength or a decline in physical performance . In other studies no association with muscle mass, muscle strength, or physical performance was observed . A reason why we may not have been able to show these associations is the relatively high mean level of 25OHD in our cohort (30.1 ng/mL).…”
Section: Discussion
contrasting
confidence: 68%
How this paper cites the one you are viewing
“…Circulating vitamin E was investigated in only three previous studies where plasma α-tocopherol was positively associated with measures of grip and knee strength, performance or decline in physical function. However, two studies found no associations between intake of vitamin E and either grip strength or function [12,14,17,32]. Our finding of a positive relationship with dietary vitamin E and certain indices of fat-free mass further supports the relevance of vitamin E to skeletal muscle health.…”
Section: Comparison With Other Studies
supporting
confidence: 66%