Serum mianserin and ageing

Antidepressants in the elderly: challenges for study design and their interpretation

“…Several pharmacokinetic studies have been performed in the elderly although results are sometimes conflicting. One study found that ageing had no effect on the plasma concentration of mianserin [29] whilst other studies have reported an age‐associated increase in the elimination half‐life and plasma concentration [30]. In a review of the pharmacokinetics of the SSRIs, De Vane recommended that the starting and maximum doses of citalopram and paroxetine should be reduced in the elderly [31].…”

Antidepressants in the elderly: challenges for study design and their interpretation

“…Several pharmacokinetic studies have been performed in the elderly although results are sometimes conflicting. One study found that ageing had no effect on the plasma concentration of mianserin [29] whilst other studies have reported an age‐associated increase in the elimination half‐life and plasma concentration [30]. In a review of the pharmacokinetics of the SSRIs, De Vane recommended that the starting and maximum doses of citalopram and paroxetine should be reduced in the elderly [31].…”

Antidepressants in the elderly: challenges for study design and their interpretation

“…Several pharmacokinetic studies have been performed in the elderly although results are sometimes conflicting. One study found that ageing had no effect on the plasma concentration of mianserin [29] whilst other studies have reported an age‐associated increase in the elimination half‐life and plasma concentration [30]. In a review of the pharmacokinetics of the SSRIs, De Vane recommended that the starting and maximum doses of citalopram and paroxetine should be reduced in the elderly [31].…”

Antidepressants in the elderly: challenges for study design and their interpretation

“…Several pharmacokinetic studies have been performed in the elderly although results are sometimes conflicting. One study found that ageing had no effect on the plasma concentration of mianserin [29] whilst other studies have reported an age‐associated increase in the elimination half‐life and plasma concentration [30]. In a review of the pharmacokinetics of the SSRIs, De Vane recommended that the starting and maximum doses of citalopram and paroxetine should be reduced in the elderly [31].…”