Serum methanol concentrations in rats and in men after a single dose of aspartame

Alterations in antioxidant defense system in hepatic and renal tissues of rats following aspartame intake

“…The plasma concentrations of methanol, a metabolite of aspartame, were markedly increased following administration of a small amount of aspartame [12]. The antioxidant defense system involving cellular GSH content and the activities of associated enzymes were reduced in liver tissue during methanol intoxication [38].…”

Alterations in antioxidant defense system in hepatic and renal tissues of rats following aspartame intake

“…The plasma concentrations of methanol, a metabolite of aspartame, were markedly increased following administration of a small amount of aspartame [12]. The antioxidant defense system involving cellular GSH content and the activities of associated enzymes were reduced in liver tissue during methanol intoxication [38].…”

Long-term effect of aspartame (artificial sweetener) on ATPases, antioxidant status and histopathology in the rat brain

“…13 A small amount of aspartame significantly increases the plasma methanol level. 38 Moreover this increase in blood methanol level was associated with a marked increase in the free radical generation in brain regions of aspartame treated MTX animals. 13 This increase in free radical may be the cause behind the decrease in the activity of membrane bound ATPases as well as decrease in creatine kinase activity observed in this study, as lipid per oxidation alters the membrane integrity.…”

Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR–CaMKII–ERK/CREB signalling on consumption of aspartame in rat model

“…It has been reported that following aspartame consumption, the concentrations of its metabolites are increased in the blood stream [ 23 ]. A small amount of aspartame significantly increases the plasma methanol level [ 24 ]. Further, it was reported that not only the metabolites of methanol, but methanol per se as well, is toxic to the brain [ 4 ].…”

Alterations in antioxidant defense system in hepatic and renal tissues of rats following aspartame intake

“…The plasma concentrations of methanol, a metabolite of aspartame, were markedly increased following administration of a small amount of aspartame [12]. The antioxidant defense system involving cellular GSH content and the activities of associated enzymes were reduced in liver tissue during methanol intoxication [38].…”

Long-term effect of aspartame (artificial sweetener) on ATPases, antioxidant status and histopathology in the rat brain

“…13 A small amount of aspartame significantly increases the plasma methanol level. 38 Moreover this increase in blood methanol level was associated with a marked increase in the free radical generation in brain regions of aspartame treated MTX animals. 13 This increase in free radical may be the cause behind the decrease in the activity of membrane bound ATPases as well as decrease in creatine kinase activity observed in this study, as lipid per oxidation alters the membrane integrity.…”

Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR–CaMKII–ERK/CREB signalling on consumption of aspartame in rat model

“…It has been reported that following aspartame consumption, the concentrations of its metabolites are increased in the blood stream [ 23 ]. A small amount of aspartame significantly increases the plasma methanol level [ 24 ]. Further, it was reported that not only the metabolites of methanol, but methanol per se as well, is toxic to the brain [ 4 ].…”

Alterations in antioxidant defense system in hepatic and renal tissues of rats following aspartame intake

“…The plasma concentrations of methanol, a metabolite of aspartame, were markedly increased following administration of a small amount of aspartame [12]. The antioxidant defense system involving cellular GSH content and the activities of associated enzymes were reduced in liver tissue during methanol intoxication [38].…”

Long-term effect of aspartame (artificial sweetener) on ATPases, antioxidant status and histopathology in the rat brain

“…13 A small amount of aspartame significantly increases the plasma methanol level. 38 Moreover this increase in blood methanol level was associated with a marked increase in the free radical generation in brain regions of aspartame treated MTX animals. 13 This increase in free radical may be the cause behind the decrease in the activity of membrane bound ATPases as well as decrease in creatine kinase activity observed in this study, as lipid per oxidation alters the membrane integrity.…”

Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR–CaMKII–ERK/CREB signalling on consumption of aspartame in rat model

“…It has been reported that following aspartame consumption, the concentrations of its metabolites are increased in the blood stream [ 23 ]. A small amount of aspartame significantly increases the plasma methanol level [ 24 ]. Further, it was reported that not only the metabolites of methanol, but methanol per se as well, is toxic to the brain [ 4 ].…”