Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture

Szabo, David T.; Pathmasiri, Wimal; Sumner, Susan; Birnbaum, Linda S.

doi:10.1289/ehp242

Cited by 28 publications

(6 citation statements)

References 44 publications

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“…The doses used in this work are lower or in the range of previous studies carried out to examine the impact of TCDD, PhIP and B[ a ]P on the gut microbiota, allowing us to make comparisons and generate discussions 13 , 14 , 16 , 21 , 22 . The doses used for PAH, HBCD and deltamethrin exposures were far lower than those used for toxicity studies in mice 30 – 32 . The doses used in this study are still higher than the expected daily consumption.…”

Section: Discussionmentioning

confidence: 98%

Food Chemicals Disrupt Human Gut Microbiota Activity And Impact Intestinal Homeostasis As Revealed By In Vitro Systems

Defois

Ratel²,

Garrait

et al. 2018

Sci Rep

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Growing evidence indicates that the human gut microbiota interacts with xenobiotics, including persistent organic pollutants and foodborne chemicals. The toxicological relevance of the gut microbiota-pollutant interplay is of great concern since chemicals may disrupt gut microbiota functions, with a potential impairment of host homeostasis. Herein we report within batch fermentation systems the impact of food contaminants (polycyclic aromatic hydrocarbons, polychlorobiphenyls, brominated flame retardants, dioxins, pesticides and heterocyclic amines) on the human gut microbiota by metatranscriptome and volatolome i.e. “volatile organic compounds” analyses. Inflammatory host cell response caused by microbial metabolites following the pollutants-gut microbiota interaction, was evaluated on intestinal epithelial TC7 cells. Changes in the volatolome pattern analyzed via solid-phase microextraction coupled to gas chromatography-mass spectrometry mainly resulted in an imbalance in sulfur, phenolic and ester compounds. An increase in microbial gene expression related to lipid metabolism processes as well as the plasma membrane, periplasmic space, protein kinase activity and receptor activity was observed following dioxin, brominated flame retardant and heterocyclic amine exposure. Conversely, all food contaminants tested induced a decreased in microbial transcript levels related to ribosome, translation and nucleic acid binding. Finally, we demonstrated that gut microbiota metabolites resulting from pollutant disturbances may promote the establishment of a pro-inflammatory state in the gut, as stated with the release of cytokine IL-8 by intestinal epithelial cells.

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Section: Discussionmentioning

confidence: 98%

Food Chemicals Disrupt Human Gut Microbiota Activity And Impact Intestinal Homeostasis As Revealed By In Vitro Systems

Defois

Ratel²,

Garrait

et al. 2018

Sci Rep

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“…The predominance of α-HBCD in biota samples is probably related to the selective metabolism or biotransformation of the three isomers [62]. For instance, Szabo et al [63] observed in mice the bio-isomerization of γ-HBCD to α-HBCD; in addition, in vitro experiments showed a faster rate of biotransformation of βand γ-HBCD than α-HBCD [64]. It is also plausible that physicochemical differences among the HBCD molecules can contribute to the mentioned pattern: α-HBCD has a relatively higher water solubility than γand β-HBCD, which may result in some preferential uptake of this isomer in the aquatic environment [65].…”

Section: Discussionmentioning

confidence: 99%

Risk Characterization and Benefit–Risk Assessment of Brominated Flame Retardant in Commercially Exploited Freshwater Fishes and Crayfish of Lake Trasimeno, Italy

Roila

Branciari

Stramenga

et al. 2021

IJERPH

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Among brominated flame retardants (BFRs), polybrominateddiphenyl ethers (PBDEs) and hexabromocyclododecanes (HBCDs) were the most widely used in past decades. BFRs not being chemically bonded to polymers means they can easily leach from the products into the environment and bioaccumulate. Humans are exposed to flame retardants mainly through food consumption, especially fish and fish products. In the present study, the occurrence of PBDEs and HBCDs in freshwater fishes and crayfish from Lake Trasimeno (Umbria region, central Italy) was assessed according to monitoring plans recommended by European competent authorities. The dietary exposure of the central Italian population to such molecules was calculated, and the risk characterization and the benefit–risk evaluation were also assessed. A total of 90 samples were analyzed by means of gas and liquid chromatography associated with triple quadrupole mass spectroscopy. A total of 51% of samples were found positive for at least one of the congeners; the most frequently found molecule was BDE-47. The data on dietary exposure ranged from 0.138 to 1.113 pg/kg body weight/day for ∑PBDE and from 0.805 to 0.868 pg/kg body weight/day for ∑HBCD. The data show no health risks for the central Italian population consuming freshwater fish products from Lake Trasimeno in relation to exposure to PBDE and HBCD.

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“…The authors described that the use of metabolomics is an important and useful approach when we want to study the effect of a compound on the body to help identify biomarkers. [ 96 ]…”

Section: Studies In Animal Modelsmentioning

confidence: 99%

Occurrence and Health Effects of Hexabromocyclododecane: An Updated Review

Marques

Cairrão

2023

Toxics

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Hexabromocyclododecane (HBCD) is a non-aromatic compound belonging to the bromine flame retardant family and is a known persistent organic pollutant (POP). This compound accumulates easily in the environment and has a high half-life in water. With a variety of uses, the HBCD is found in house dust, electronics, insulation, and construction. There are several isomers and the most studied are α-, β-, and γ-HBCD. Initially used as a substitute for other flame retardants, the polybrominated diphenyl ethers (PBDEs), the discovery of its role as a POP made HBCD use and manufacturing restricted in Europe and other countries. The adverse effects on the environment and human health have been piling, either as a result from its accumulation or considering its power as an endocrine disruptor (ED). Furthermore, it has also been proven that it has detrimental effects on the neuronal system, endocrine system, cardiovascular system, liver, and the reproductive system. HBCD has also been linked to cytokine production, DNA damage, increased cell apoptosis, increased oxidative stress, and reactive oxygen species (ROS) production. Therefore, this review aims to compile the most recent studies regarding the negative effects of this compound on the environment and human health, describing the possible mechanisms by which this compound acts and its possible toxic effects.

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Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture

Cited by 28 publications

References 44 publications

Food Chemicals Disrupt Human Gut Microbiota Activity And Impact Intestinal Homeostasis As Revealed By In Vitro Systems

Food Chemicals Disrupt Human Gut Microbiota Activity And Impact Intestinal Homeostasis As Revealed By In Vitro Systems

Risk Characterization and Benefit–Risk Assessment of Brominated Flame Retardant in Commercially Exploited Freshwater Fishes and Crayfish of Lake Trasimeno, Italy

Occurrence and Health Effects of Hexabromocyclododecane: An Updated Review

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