Serum lycopene decreases the risk of stroke in men

Karppi, Jouni; Laukkanen, Jari A.; Sivenius, Juhani; Ronkainen, Kimmo; Kurl, Sudhir

doi:10.1212/wnl.0b013e31826e26a6

Cited by 67 publications

(52 citation statements)

References 37 publications

(34 reference statements)

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“…However, epidemiological studies have generated conflicting results regarding lycopene and stroke. For example, an inverse association between circulating lycopene and stroke risk has been reported in some prospective studies8915, whereas other studies that focused on dietary lycopene intake have found inconsistent associations with stroke risk; some have shown negative associations161718 and some have reported positive ones19. In view of this uncertainty, we conducted a meta-analysis to address the relationships between the intake of lycopene or tomato-based products, as well as circulating lycopene, and the occurrence or mortality of stroke, which is defined as risk of stroke in our present study.…”

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confidence: 88%

Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies

2014

Sci Rep

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Epidemiological studies support a protective role of lycopene against stroke occurrence or mortality, but the results have been conflicting. We conducted a meta-analysis to assess the relationship between dietary or circulating lycopene and stroke risk (including stroke occurrence or mortality). Relevant papers were collected by screening the PubMed database through October 2013. Only prospective studies providing relative risk estimates with 95% confidence intervals for the association between lycopene and stroke were included. A random-effects model was used to calculate the pooled estimate. Subgroup analysis was conducted to investigate the effects of various factors on the final results. The pooled analysis of seven prospective studies, with 116,127 participants and 1,989 cases, demonstrated that lycopene decreased stroke risk by 19.3% (RR = 0.807, 95% CI = 0.680–0.957) after adjusting for confounding factors. No heterogeneity was observed (p = 0.234, I2 = 25.5%). Circulating lycopene, not dietary lycopene, was associated with a statistically significant decrease in stroke risk (RR = 0.693, 95% CI = 0.503–0.954). Lycopene could protect European, or males against stroke risk. Duration of follow-up had no effect on the final results. There was no evidence of publication bias. Lycopene, especially circulating lycopene, is negatively associated with stroke risk.

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confidence: 88%

Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies

2014

Sci Rep

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“…The mechanism is not clearly known, although reduction of blood pressure is thought to play an important role. A recent study reported that high plasma levels of lyocopene (e.g., found in tomatoes) were associated with a reduced risk of stroke by 50% [63]. Moderate consumption (3-4 cups) of coffee or tea has been shown to reduce stroke risk as compared with no consumption [64,65].…”

Section: Lifestyle Modificationmentioning

confidence: 99%

Stroke Prevention - Medical and Lifestyle Measures

2015

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Background: According to the World Health Organization, stroke is the ‘incoming epidemic of the 21st century'. In light of recent data suggesting that 85% of all strokes may be preventable, strategies for prevention are moving to the forefront in stroke management. Summary: This review discusses the risk factors and provides evidence on the effective medical interventions and lifestyle modifications for optimal stroke prevention. Key Messages: Stroke risk can be substantially reduced using the medical measures that have been proven in many randomized trials, in combination with effective lifestyle modifications. The global modification of health and lifestyle is more beneficial than the treatment of individual risk factors. Clinical Implications: Hypertension is the most important modifiable risk factor for stroke. Efficacious reduction of blood pressure is essential for stroke prevention, even more so than the choice of antihypertensive drugs. Indications for the use of antihypertensive drugs depend on blood pressure values and vascular risk profile; thus, treatment should be initiated earlier in patients with diabetes mellitus or in those with a high vascular risk profile. Treatment of dyslipidemia with statins, anticoagulation therapy in atrial fibrillation, and carotid endarterectomy in symptomatic high-grade carotid stenosis are also effective for stroke prevention. Lifestyle factors that have been proven to reduce stroke risk include reducing salt, eliminating smoking, performing regular physical activity, and maintaining a normal body weight.

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“…Carotenoid lycopene is a particularly beneficial carotenoid; it aids in the prevention of coronary heart disease [14], myocardial infarction [15,16], and ischemic strokes [17], as well as for deceleration of early atherosclerosis' progression [17,18]. It can also lower systolic blood pressure [19].…”

Section: Introductionmentioning

confidence: 99%

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Lashmanova

Proshkina

Zhikrivetskaya

et al. 2015

Pharmacological Research

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Serum lycopene decreases the risk of stroke in men

Abstract: This prospective study shows that high serum concentrations of lycopene, as a marker of intake of tomatoes and tomato-based products, decrease the risk of any stroke and ischemic stroke in men.

Cited by 67 publications

References 37 publications

Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies

Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies

Stroke Prevention - Medical and Lifestyle Measures

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

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