Serum levels of prostate-specific antigen in normal boys throughout puberty.

Vieira, José Gilberto H.; Nishida, Sônia K.; Pereira, Adriana de Fátima Vasconcelos; Arraes, R. F.; Verreschi, Ieda Therezinha do Nascimento

doi:10.1210/jcem.78.5.7513717

Cited by 21 publications

(24 citation statements)

References 16 publications

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“…In our KS boys, serum SHBG decreased normally and the levels did not differ from those observed in the controls. During puberty, serum PSA levels are in healthy boys a potential marker of T action (32)(33)(34)(35). The normal increase in serum PSA during puberty in our cohort of boys with KS suggests sufficient androgen action in the prostate.…”

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confidence: 66%

Are Adolescent Boys with Klinefelter Syndrome Androgen Deficient? A Longitudinal Study of Finnish 47,XXY Boys

et al. 2006

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Testosterone (T)-substitution therapy is widely used in adult patients with Klinefelter syndrome (KS) to prevent symptoms and sequels of androgen deficiency, but it is currently unknown if adolescent boys with KS benefit from early T therapy. To evaluate the optimal age to start T substitution, we searched for signs of androgen deficiency in pubertal boys with KS. 14 nonmosaic 47,XXY boys, aged 10 -13.9 y, were followed up for 4 -37 mo with staging of puberty and frequent reproductive hormone measurements. Furthermore, indices reflecting androgen action (serum SHBG, leptin, and prostate-specific antigen (PSA) levels) were studied. Both onset and progression of puberty according to Tanner stages were normal in boys with KS. Consistently, serum T concentrations increased as expected and remained normal throughout follow-up. Changes in the indices of androgen action (decreases in serum SHBG and leptin, and increase in serum PSA concentrations) occurred normally, except that average leptin levels were higher in the boys with KS (KS boys 11.8 Ϯ 7.0 g/L; controls 7.6 Ϯ 4.7 g/L; p ϭ 0.033). Despite normal T concentrations, the KS boys displayed from the age of 13 y elevated serum FSH and LH levels, and exaggerated gonadotropin responses to gonadotropin-releasing hormone. These data do not demonstrate an unequivocal androgen deficiency in adolescent boys with KS that would necessitate androgen supplementation therapy during early puberty.

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confidence: 66%

Are Adolescent Boys with Klinefelter Syndrome Androgen Deficient? A Longitudinal Study of Finnish 47,XXY Boys

et al. 2006

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“…No statistical connection was established between ED and LUTS (p>0.05). Serum PSA level is varies according to age, gender and the prostate volume [14].PSA level shows an increase of 0,04 ng/ml per year in men without benign prostatic hyperplasia [15].However change rate of PSA level is 0,07 to 0,27 ng/ml per year in men between the ages of 60-85 with BPH [16]. Each of the increase 1 ml in prostate volume are known to enhance of PSA 4% [17].…”

Section: Resultsmentioning

confidence: 99%

“…A score ranging from 0 to 5 was assigned with "5 times" or "6 or more times" corresponding to a score of 5. These scores were summed to create a score ranging from 0 to 35, which we categorized into 4 groups: no or low (0-7), low-moderate (8)(9)(10)(11)(12)(13)(14), high-moderate (15)(16)(17)(18)(19), The maximum score is 25. Using acutoff score of 21, the sensitivity and specificity of discriminating between ED and no-ED are 0.98 and 0.88, respectively [11].…”

Section: Introductionmentioning

confidence: 99%

Associations Between PSA Levels and Erectile Dysfunction in the Patient with LUTS

Çelik¹,

Çamtosun²,

Ediz³

et al. 2016

Med-Science

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“…A direct relationship between androgen level and PSA synthesis on RNA [14] and protein-level has been described in vitro [15] and PSA was suggested to be a useful marker of testosterone activity in vivo [16,17]. Further, androgen replacement therapy results in modest PSA elevations in healthy old men [18] as well as in men treated for hypogonadism or osteoporosis [19].…”

Section: Introductionmentioning

confidence: 99%

Androgen deprivation decreases prostate specific antigen in the absence of tumor: implications for interpretation of PSA results

Wenisch

Mayr

Spiel

et al. 2013

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Prostate-specific antigen (PSA) is used as an outcome measure for relapsed disease in prostate cancer. Nonetheless, there are considerable concerns about its indiscriminate use as a surrogate endpoint for cell growth or survival. We hypothesized that treatment with a luteinizing hormone releasing hormone (LHRH) analog would decrease PSA levels even in the absence of malignant disease. Methods: We determined testosterone and PSA levels in 30 healthy volunteers after a single intramuscular injection of a LHRH depot formulation. Testosterone and PSA levels were quantified by radioimmunoassay and electrochemi-luminescence immunoassay, respectively. Results: After an initial flare-up during the first 3 days testosterone decreased reaching castration levels in 18 of the 30 young men (60%). After the nadir on day 28, testosterone levels increased to normal again. Changes in PSA paralleled those of testosterone. Castration reduced PSA levels by 29% (95% CI 19%-39%) compared to baseline (p < 0.0001). Conclusions: LHRH superagonists decrease PSA levels by testosterone deprivation. Conferring these findings to tumor patients, decreases in PSA after treatment with LHRH analogs might not only reflect disease regression but also a direct testosterone mediated effect on PSA. Thus, PSA levels should be cautiously interpreted when patients receive hormonal therapy.

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Serum levels of prostate-specific antigen in normal boys throughout puberty.

Cited by 21 publications

References 16 publications

Are Adolescent Boys with Klinefelter Syndrome Androgen Deficient? A Longitudinal Study of Finnish 47,XXY Boys

Are Adolescent Boys with Klinefelter Syndrome Androgen Deficient? A Longitudinal Study of Finnish 47,XXY Boys

Associations Between PSA Levels and Erectile Dysfunction in the Patient with LUTS

Androgen deprivation decreases prostate specific antigen in the absence of tumor: implications for interpretation of PSA results

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