Serum Levels of Oxidative Stress Biomarkers in Patients Obsessive Compulsive Disorder in Tikrit City, Iraq

Mohammed, Mohammed Amer; Hilal, Nihad Nejres; Ani, Ahmed Hashim Al

doi:10.5958/0976-5506.2019.02983.8

Cited by 4 publications

(7 citation statements)

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“…Our systematic review included nine case–control studies [ 22 , 23 , 26 , 27 , 32 – 36 ]. Figure 1 presents a flow diagram for study selection.…”

Section: Resultsmentioning

confidence: 99%

“…The included studies were published between 2002 and 2019. Four studies were conducted in Turkey [ 23 , 26 , 33 , 34 ], three in India [ 27 , 32 , 35 ], one in Bangladesh [ 22 ], and Iraq [ 36 ]. Among the studies, one was conducted on male subjects [ 32 ], the six were conducted on both genders [ 22 , 23 , 26 , 33 – 35 ], and two other studies did not report the gender of the subjects [ 27 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

“…The mean disease duration ranged from 3.9 to 11.26 years. OCD was diagnosed based on DSM-IV in seven studies [ 22 , 23 , 26 , 27 , 32 – 34 ], while one study used ICD-10-DCR [ 35 ] and one study did not report the diagnostic method [ 36 ]. In addition, two studies used Y-BOCS to assess the severity of OCD [ 26 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, two studies used Y-BOCS to assess the severity of OCD [ 26 , 35 ]. Moreover, few studies did not report the Y-BOCS outcome [ 22 , 23 , 27 , 32 – 34 , 36 ]. MDA level was measured based on the method developed by Satoh [ 22 , 32 , 33 ], Ohkawa [ 34 , 35 ], Jain [ 23 , 26 ], Wills [ 27 ] and one study used ELISA method [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

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Malondialdehyde concentrations in obsessive–compulsive disorder: a systematic review and meta-analysis

2021

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Background This meta-analysis aimed to investigate serum and plasma malondialdehyde (MDA) levels in patients with obsessive–compulsive disorder (OCD) in comparison to healthy controls. Methods Following the PRISMA protocol, we searched for the relevant studies through the databases of Scopus, PubMed, Google Scholar, and web of science until September 2019 with no time restriction. Overall, nine studies were included in the current meta-analysis. Data were pooled using a random-effects model; in addition, standard mean difference (SMD) and/or weight mean difference (WMD) was calculated. Cochran’s Q test and I-square (I2) statistics were used to evaluate between-study heterogeneity. The Newcastle–Ottawa scale (NOS) was used to evaluate the quality of the included studies. Statistical analyses were done using the STATA version 14. Results Our systematic review included nine case–control studies (including 367 cases and 337 controls). Pooling findings from these studies showed a significantly higher MDA level in OCD patient compared to control groups (SMD = 1.62; 95% CI [0.53, 2.72]; I2 = 96.9%; Pheterogeneity (Ph) < 0.001). This finding remained unchanged among studies which reported MDA in the same unit (WMD = 1.93; 95% CI [0.27, 3.59]; I2 = 99.2%; Ph < 0.001). Subgroup analysis by the study location and sample size revealed findings that were also significant. Conclusion We found that MDA levels are higher in OCD patients than healthy controls. This finding highlights the importance of inflammatory responses in OCD patients that should be considered for future investigations. Further studies are recommended to expand current knowledge on this issue.

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“…Our systematic review included nine case–control studies [ 22 , 23 , 26 , 27 , 32 – 36 ]. Figure 1 presents a flow diagram for study selection.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Malondialdehyde concentrations in obsessive–compulsive disorder: a systematic review and meta-analysis

2021

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“…Also, patients with OCD had lower ATPase activity compared to healthy controls. Some case control studies (33)(34)(35)(36)(37)(38)(39)(40) and a meta-analysis (41) concentrated on the relationship between OCD and MDA. In contrast with our study, Ranjekar et al observed no signi cant differences in serum levels of lipid peroxidation markers between patients with schizophrenic and healthy control (42), and kurup et al found that OCD patients had lower MDA level than controls (43).…”

Section: Discussionmentioning

confidence: 99%

The Oxidative Status and Na +/K + -ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study

Mohammadi

Balandeh

Hasani

et al. 2021

Preprint

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Background: Oxidative stress is involved in pathogenesis of some psychiatric disorders. To examine the role of oxidative stress in the etiopathogenesis of obsessive-compulsive disorder (OCD), we aimed to determine oxidative stress indices, including MDA levels in serum and red blood cells (RBC) membrane, total antioxidant capacity (TAC), serum glutathione (GSH) levels, serum antioxidant vitamins (A and E) and Na+/K+-ATPase activity in patients with the mentioned disorder vs. healthy controls.Method: 39 OCD patients diagnosed based on Diagnostic and Statistical Manual of Mental Disorders (DSM-V), and 39 volunteers’ healthy subjects were included in this study. MDA levels in serum and RBC membrane were measured using fluorimetric method. Serum TAC level, serum GSH level and Na+/K+-ATPase activity were also measured using spectrophotometric methods. Serum levels of vitamins were calculated by Reversed-phase high-performance liquid chromatography (RP-HPLC).Result: There was a significantly higher MDA level in serum (p<0.0001) and RBC membrane (p=0.002) of OCD patients compared with those in controls. A significant reduction in vitamin A (p=0.024) and vitamin E (p=0.001) levels was found in OCD patients vs. controls. There was significantly lower activity of erythrocyte membrane Na+-K+ ATPase in RBC membrane of OCD patients vs. controls (p<0.0001).Conclusion: Our findings indicate significantly higher levels MDA in both serum and RBC membrane, lower levels of serum vitamin A and E, and lower activity of membrane Na+-K+ ATPase in OCD patients compared to controls. These suggest an imbalance between oxidant and antioxidant factors in OCD patients that might play a fundamental role in the etiopathogenesis of OCD.

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The Oxidative Status and Na+/K+-ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study

Mohammadi,

Balandeh,

Hasani

et al. 2024

BioMed Research International

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Background. Oxidative stress is involved in pathogenesis of some psychiatric disorders. To examine the role of oxidative stress in the etiopathogenesis of obsessive-compulsive disorder (OCD), we aimed to determine oxidative stress indices, including malondialdehyde (MDA) levels in serum and red blood cells (RBC) membrane, total antioxidant capacity (TAC), serum glutathione (GSH) levels, serum antioxidant vitamins (A and E), and Na+/K+-ATPase activity, in patients with the mentioned disorder vs. healthy controls. Method. 39 OCD patients diagnosed based on Diagnostic and Statistical Manual of Mental Disorders (DSM-V) and 39 volunteer healthy subjects were included in this study. MDA levels in serum and RBC membrane were measured using fluorometric method. Serum TAC level, serum GSH level, and Na+/K+-ATPase activity were also measured using spectrophotometric methods. Serum levels of vitamins were calculated by reversed-phase high-performance liquid chromatography (RP-HPLC). Result. There was a significantly higher MDA level in serum (p<0.0001) and RBC membrane (p=0.002) of OCD patients compared with those in controls. A significant reduction in vitamin A (p=0.001) and vitamin E (p=0.024) levels was found in OCD patients vs. controls. There was significantly lower activity of erythrocyte membrane Na+/K+-ATPase in RBC membrane of OCD patients vs. controls (p<0.0001). Conclusion. Our findings indicate significantly higher levels MDA in both serum and RBC membrane, lower levels of serum vitamins A and E, and lower activity of membrane Na+/K+-ATPase in OCD patients compared to controls. These suggest an imbalance between oxidant and antioxidant factors in OCD patients that might play a fundamental role in the etiopathogenesis of OCD.

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Serum Levels of Oxidative Stress Biomarkers in Patients Obsessive Compulsive Disorder in Tikrit City, Iraq

Cited by 4 publications

References 0 publications

Malondialdehyde concentrations in obsessive–compulsive disorder: a systematic review and meta-analysis

Malondialdehyde concentrations in obsessive–compulsive disorder: a systematic review and meta-analysis

The Oxidative Status and Na +/K + -ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study

The Oxidative Status and Na+/K+-ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study

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