Serum levels of malondialdehyde, vitamin C and E in idiopathic nephrotic syndrome: a meta-analysis

Mao, Song; Zhang, Aihua; Huang, Songming

doi:10.3109/0886022x.2014.900430

Cited by 6 publications

(6 citation statements)

References 27 publications

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“…(2) Dietary factors are believed to play positive roles in reducing risk of cardiometabolic diseases, especially vitamin E supplementation. (3,4) In agreement, several observational studies (5)(6)(7)(8)(9)(10) suggested that vitamin E intake had a beneficial effect on protecting against cardiometabolic diseases. However, a large body of compelling literatures suggested that increased vitamin E intake was more likely to be associated with higher risk of cardiometabolic diseases.…”

supporting

confidence: 59%

Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis

Fan

Huang

Kong

et al. 2019

J. Clin. Biochem. Nutr.

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Although a large body of literature reported that high intake of vitamin E played a possible role in reducing risk of cardiometabolic diseases, conflicting results were also found in some observational studies due to confounding factors. Hence, we used a Mendelian randomization study as an alternative way to examine the causality between circulating vitamin E and cardiometabolic diseases. Summary level data were extracted from consortia and three single nucleotide polymorphisms were used as instrumental variables. Our study showed that a one SD increase in circulating vitamin E levels was causally associated with an increased risk of coronary artery disease [odds ratio (OR) 3.16 (95%CI 1.74, 5.73); p = 1.91 × 10-3 ] at the Bonferroni adjusted level of significance (p<0.005). Moreover, a one SD increase in circulating vitamin E levels was associated with a 0.572 SD increase in low density lipo protein cholesterol (mg/dl), a 0.693 SD increase in total cholesterol (mg/dl), and a 1.45 SD increase in triglyceride (mg/dl), but a 0.502 SD decrease in high density lipoprotein cholesterol (mg/dl) at the Bonferroni adjusted level of significance (p<0.0028). Our findings indicated that genetically elevated vitamin E was associated with increased risk of coronary artery disease, suggesting an adverse causality between circulating vitamin E and coronary artery disease.

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supporting

confidence: 59%

Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis

Fan

Huang

Kong

et al. 2019

J. Clin. Biochem. Nutr.

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“…Phospholipids on cell membranes can be oxidized as oxidative stress damage, thus a stable lipid peroxide MDA was formed. MDA content reflects the degree of lipid peroxidation in the body as well as ROS attacking on cells (45). SOD is an important defense against free radical damage in organisms.…”

Section: Discussionmentioning

confidence: 99%

Ligustrazine nanoparticles nano spray’s activation on Nrf2/ARE pathway in oxidative stress injury in rats with postoperative abdominal adhesion

Yan¹,

Yue²,

Zeng³

et al. 2019

Ann. Transl. Med.

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Background: Postoperative abdominal adhesions formation is considered a significant clinical entity implicating the healing process following major pelvic and abdominal surgery, with serious clinical complications and need for substantial health care expenditures. However, setting a physical barrier between the damage site and the neighboring tissues is a convenient and highly valid way to minimize or prevent peritoneal adhesions. The present experimental study evaluated the preventive effect of ligustrazine nanoparticles nano spray (LNNS) on postoperative abdominal adhesion in rats and explored its mechanism.Methods: Sixty male Sprague Dawley (SD) rats were randomly divided into sham operation group, control group, sodium hyaluronate group and low, medium, and high dose LNNS groups. All groups were prepared with abdominal adhesion models except for the sham operation group. The models were made by opening the abdominal cavity to and filing the serosa in ileocecal junction. The abdominal cavity of rats in the sham operation group were only opened and sutured. The wound surface of rats in the sodium hyaluronate group, low, medium, and high dose LNNS groups were sprayed with sodium hyaluronate gel (0.5 mL/kg) and LNNS (2.5, 5, and 10 mL/kg). Rats in each group were sacrificed 7 days later. Degree of adhesion was evaluated by naked eyes and the pathological sections were scored afterwards. The collagen synthesis in adhesion tissues was detected by Masson's trichrome stain, and the activities of reactive oxygen species (ROS), nitric oxide (NO), superoxide dismutase (SOD) and malondialdehyde (MDA) in peritoneal fluid were detected with the method of chromogenic substrate. Levels of TNF-α and IL-1β in serum, and the protein levels of MCP-1 and MMP-9 in adhesion tissues were detected by ELISA and. immunohistochemistry respectively. RT-PCR and Western blot were utilized to identify the expression levels of Nrf2, heme-oxygenase-1, NQO1 mRNA and protein in adherent intestinal tissues.Results: Compared with the control group, the incidence of postoperative abdominal adhesions decreased in the low, medium and high dose LNNS groups, while the expression of SOD in the peritoneal fluid significantly increased. The expression levels of ROS, MDA and NO were reduced remarkably (P<0.05), so were the expression levels of serum TNF-α and IL-1β (P<0.01) and the expression of MCP-1 protein in adhesion tissues. The MMP-9 protein expression, and Nrf2, heme-oxygenase-1, NQO1 mRNA and protein expressions increased.Conclusions: LNNS with medium or high dose can significantly reduce the incidence of postoperative abdominal adhesions, the mechanism of which may be the activation of Nrf2/ARE pathway, resulting in the up-regulation of Nrf2, heme-oxygenase-1, NQO1 and mRNA expression, as well as the levels of TNF-α Yan et al. LNNS ameliorates postoperative peritoneal adhesion formation

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“…Oxidative stress can contribute to the development and progression of NS by damaging the glomerular filtration barrier, promoting inflammation, altering lipid metabolism, impairing endothelial function and causing cellular damage (2,8). Several studies have shown that NS patients experience high levels of oxidative stress during the acute phase of the condition, and some studies have reported that oxidative stress markers remain elevated even after steroidinduced remission of the disease (7,9,10). Oxidative stress assessment entails evaluating both damaged stable molecules and antioxidant molecules, including enzymatic and non-enzymatic antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Pediatric nephrotic syndrome: The interplay of oxidative stress and inflammation

Mulat,

Mihajlović,

Antonić

et al. 2024

J Med Biochemistry

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Summary Background: The pathophysiological mechanisms crucial in the development of nephrotic syndrome (NS) in the pediatric population are still not fully understood. This study aims to investigate the synergistic interaction of oxidative stress and inflammation in the pathogenesis of NS. Additionally, one of the objectives of this study is to examine the relationship between hypertension and the degree of oxidative stress and inflammation in patients during the acute phase of the disease. Methods: The study included 33 children, aged 2 to 9 years, with NS. Blood samples were collected during the acute phase and remission. Parameters of oxidative status were determined, including total oxidative status (TOS), advanced oxidation protein products (AOPP), prooxidant-antioxidant balance (PAB), sulfhydryl groups (-SH), paraoxonase 1 (PON1), and total antioxidant status (TAS) in serum, measured spectrophotometrically. Inflammatory parameters such as pentraxin 3 (PTX3), leptin, programmed cell death ligand 1 (PD-L1), and E-cadherin were determined using enzyme-linked immunosorbent assay (ELISA). Results: Patients with NS and hypertension had significantly higher levels of AOPP and TOS (p=0.029 and p=0.003, respectively). During the acute phase of the disease, lower activity of -SH and PON1 was observed compared to remission (p<0.001, for both). PTX3 levels were higher, while leptin levels were lower during the acute phase (p<0.001, for both). PTX3 correlated with AOPP and TAS during the acute phase but not in remission (rs=0.42, p=0.027 and rs=0.43, p=0.025, respectively). A negative correlation between AOPP and leptin was observed during the acute phase, which disappeared in remission (rs=-0.42, p=0.028). Conclusions: Results of this study show that hypertension influences oxidative stress markers, and decreased antioxidant capacity may contribute to NS development. PTX 3 appears as a potential disease activity marker, indicating a dynamic connection between inflammation and oxidative stress. Leptin may also play a role in oxidative stress in NS. List of abbreviations: AOPP, advanced oxidation protein products; BMI, body mass index; DBP, diastolic blood pressure; ELISA, enzyme-linked immunosorbent assay; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; total antioxidant status; PAB, prooxidant-antioxidant balance; -SH, sulfhydryl group; SBP, systolic blood pressure; PON 1, paraoxonase; PTX 3, pentraxin 3; PD-L1, programmed cell death ligand 1; TC, total cholesterol; TG, triglyceride; TAS, total antioxidant status; TOS, total oxidation status.

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Serum levels of malondialdehyde, vitamin C and E in idiopathic nephrotic syndrome: a meta-analysis

Cited by 6 publications

References 27 publications

Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis

Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis

Ligustrazine nanoparticles nano spray’s activation on Nrf2/ARE pathway in oxidative stress injury in rats with postoperative abdominal adhesion

Pediatric nephrotic syndrome: The interplay of oxidative stress and inflammation

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